Aníbal Eugênio Vercesi

• Abstract

  This proposal concerns a joint research project of the groups of Prof. Anibal Vercesi (Department of Clinical Pathology) and the research group of Prof. Pedro L.O. Volpe (Institute of Chemistry, Unicamp) with the group of Prof. Johannes Lerchner (TU Bergakademie Freiberg, Germany) to develop new chip calorimetry based methods for the investigation of the energy metabolism of Trypanosoma c…

  Chip-calorimetric investigations on the energy metabolism of Trypanosoma cruzi, AV.EXT

• Abstract

  In the last 40 years, it has become evident that mitochondria are involved in many cell functions besides energy conversion, such as the control of cell death via calcium and oxygen and nitrogen reactive species signaling. Elevated levels of calcium in the mitochondrial matrix stimulate the generation of reactive oxygen which promote the opening of an unspecific pore in the inner mitochon…

  Mitochondrial function and dysfunction: implications for aging and associated diseases, AP.TEM

• Abstract

  Mais de 500 proteínas quinases estão presentes no genoma humano, atuando como chaves regulatórias de praticamente todos os processos fisiológicos do organismo humano. As quinases podem ser moduladas através de pequenas moléculas químicas altamente potentes. No entanto, apesar de sua importância e adequação para a descoberta de fármacos, a maioria das pesquisas acadêmicas e farmacêuticas t…

  Protein Kinase Chemical Biology Center: supporting drug development through open-access research, AP.PITE

(Only some records are available in English at this moment)

• Abstract

  We will study the role of mitochondrial NAD(P)-transhydrogenase (NNT) activity in the development of Fatty Liver Disease and aging in mice. It will be investigated the role of pyruvate dehydrogenase inhibition in the development of Fatty Liver Disease in NNT deficient mice fed a high fat diet. Additionally, the involvement of NNT activity will be evaluated in the process of mitochondrial …

  The role of mitochondrial NAD(P)-Transhydrogenase in the development of Fatty Liver Disease and aging in mice, BP.PD

• Abstract

  The parasite Trypanosoma cruzi is the etiological agent of Chagas Disease. The existing drugs have low effectiveness and high toxicity. Structural and functional studies of several proteins are underway, and they are a powerful tool in the identification and development of new chemotherapy targets. Recognized molecular targets for new chemotherapies are the proteins involved in the regula…

  Regulatory characterization of leucine zipper EF-containing transmembrane protein 1 (Letm1) in cell bioenergetic of Trypanosoma cruzi, BP.PD

• Abstract

  Brazil follows the worldwide trend of a marked increase in the number of elderly people in the population. Therefore, factors associated with aging are drawing attention, due to the relationship of aging with chronic diseases, elderly life quality, medical assistance costs and mortality risk. Many aging studies using model organisms focus on the mitochondria, multifunctional organelles th…

  Mitochondrial function and molecular markers associated with aging in the long-lived red-footed tortoise Chelonoidis carbonaria, BP.PD

(Only some records are available in English at this moment)

• Abstract

  Aging is commonly defined as an overall progressive functional decline in organisms over time with an increasing risk of disease and death. At the molecular level, aging is attributed to the accumulation of stochastic damage to tissues and cellular components. The free radical theory of aging, proposed by Harman, postulated that both aging and degenerative disease are caused by the accumu…

  Linking defects in DNA repair to activation of the inflammatory response via cGAS-STING and defects in mitophagy in mononuclear cells from humans with cognitive decline, BE.EP.PD

• Abstract

  The lipid droplets (LDs) store triglycerides (TG) and release fatty acids in response to nutrient and hormonal signals, effectively maintaining energy reserves and buffering the cell from fatty acid toxicity. The imbalance between the lipid biogenesis, cellular uptake and the energy storage cause hepatic steatosis and macrophage foam cell formation. Lipid synthesis and lipid droplets form…

  Identifying the regulatory functions of nuclear lipid synthesis and storage pathways, BE.EP.PD

• Abstract

  The lipid droplets (LDs) store triglycerides (TG) and release fatty acids in response to nutrient and hormonal signals, effectively maintaining energy reserves and buffering the cell from fatty acid toxicity. The imbalance between the lipid biogenesis, cellular uptake and the energy storage cause hepatic steatosis and macrophage foam cell formation. Lipid synthesis and lipid droplets form…

  Identifying the regulatory functions of nuclear lipid synthesis and storage pathways, BE.EP.PD