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Ministério da Ciência, Tecnologia e Inovações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Mário Tyago Murakami in research grants and scholarships supported by FAPESP.
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The plant cell wall is an important physical barrier to pathogens, and to chemical and physical stress for plants and it is essentially composed of polysaccharides of great biological and industrial importance. However, the challenge to deconstruct the plant cell wall into simple sugars is not a fully consolidated and economically viable process for many industrial applications as, for ex…
In this next project we will continue our studies regarding the class V myosins (MyoVs). The combination of structural and functional approaches will be maintained as in the previous project and our goal will be to answer new questions that arose during these two years of work. First, we want to know what the role of phosphorylation in regulating the CBD function of mammalian MyoVs. To th…
The structure-function relationship studies of glycoside hydrolases contribute to unveil new strategies to improve thermal stability, specificity, and modulation - knowledge that can be used for the development of optimized enzymes for biotechnological processes as well as to assist the rational design of enzymes. However, studies regarding the structural determinants for the different mo…
Myosin V (MyoV) motors have been implicated in the intracellular transport of diverse cargoes including vesicles, organelles, RNA-protein complexes, and regulatory proteins. Here,we have solved the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb, and Vc), revealing subtle structural changes that drive functional differentiation and anovel redox mechanism con…
(Only some records are available in English at this moment)
The production of bioactive compounds, alternative chemicals and biofuels from lignocellulosic materials is considered one of the most promising strategies to replace non-renewable petrochemical routes. One of the main challenges is the depolymerization of its components, such as cellulose and hemicellulose, into fermentable sugars. Microorganisms found in natural environments have a grea…
Plant cell wall consists of a complex and dynamic structure composed essentially by cellulose, hemicellulose, lignin and pectins. The deconstruction of the vegetal fiber by chemical or enzymatic hydrolysis releases fermentable sugars, which can be used in the production of biofuels or compounds with higher added value. However, the use of plant biomass still requires both a better underst…
The genus Xanthomonas is composed of gram-negative bacteria capable of infecting different plant species, many of them of great economic and social importance, such as rice and orange. Brazil as the second largest producer of citrus fruits in the world for decades is concerned with Citrus Canker disease, caused by the presence of the bacterium Xanthomonas citri subsp. citri, which has har…
Due to the heterogeneity and recalcitrance of lignocellulosic biomass its complete and efficient degradation is a challenge to be overcome aiming the economic viability of some bioprocesses, such as the cellulosic ethanol. One of the main factors that contribute for this is the absence of efficient and low cost enzymatic cocktails. Plant pathogens found in Xanthomonadaceae family, particu…
(Only some records are available in English at this moment)
Primary cell walls of plants are mainly composed by cellulose and hemicellulose, having xyloglucan (XyG) as the main hemicellulosic polysaccharide. The XyG structure and composition largely varies according to plant type and tissue requiring a diverse and complex repertoire of glycosyl hydrolases to be depolymerized. The genus Xanthomonas poses as one of the most widespread pathogenic bac…
Glycoside hydrolases from family 43 (GH43) act on the degradation of key polysaccharides that constitute the hemicellulose such as xylan and arabinans. However, despite this family having a strong correlation with plant cell wall deconstruction and being ubiquitous in plant biomass maceration specialized organisms, it is still poorly explored. GH43 is a very polyspecific family, divided i…
The family 5 of glycoside hydrolases (GH5) consists of more than 12000 members that recognize and hydrolyze a broad range of carbohydrates. For a better understanding of the great diversity of its enzymatic repertoire, Asperborg et al. (2012) classified the GH5 family into 51 subfamilies, from which 20 did not have available characterization data so far. In the current FAPESP doctoral pro…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 6 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 25 / 21 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 39 / 35 | All research grants and scholarships |
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