CV Lattes
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Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Engenharia from Universidade Estadual Paulista Júlio de Mesquita Filho (2003) and doctorate at Byophysics from Universidade Estadual Paulista Júlio de Mesquita Filho (2006). Has experience in Byophysics, acting on the following subjects: cazymes, biotecnologia, enzimas, biotechnology and biologia sintética. (Source: Lattes Curriculum)
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This project aims to elucidate enzymatic systems and molecular mechanisms associated with the depolymerization and metabolism of complex carbohydrates by microorganisms present in the gut microbiota of herbivores. The processing of carbohydrates by the gut microbiota plays a central role in the generation of energy (nutrition) for the host, in addition to other functions such as modulatio…
The plant cell wall is an important physical barrier to pathogens, and to chemical and physical stress for plants and it is essentially composed of polysaccharides of great biological and industrial importance. However, the challenge to deconstruct the plant cell wall into simple sugars is not a fully consolidated and economically viable process for many industrial applications as, for ex…
In this next project we will continue our studies regarding the class V myosins (MyoVs). The combination of structural and functional approaches will be maintained as in the previous project and our goal will be to answer new questions that arose during these two years of work. First, we want to know what the role of phosphorylation in regulating the CBD function of mammalian MyoVs. To th…
(Only some records are available in English at this moment)
The production of bioactive compounds, alternative chemicals and biofuels from lignocellulosic materials is considered one of the most promising strategies to replace current non-renewable petrochemical routes. One of the main challenges encountered is the depolymerization of its components, such as cellulose and hemicellulose, into fermentable sugars. Microorganisms present in natural en…
Microorganisms capability to act in complex carbohydrates feedstocks and catalyze theirdepolymerization in diverse conditions is a synergistic feature of their enzymatic apparatus.However, due to these systems diversity and complexity, the elucidation of their molecularmechanisms is limited in comparison with the number of enzyme sequences available. Thisphenomenon is even more pronounced…
The breakdown and modification of carbohydrates represents one of the most important biocatalytic reactions in nature and is present in several technological processes such as in the beverage, food, biofuels industry, among many others. The omics studies of microbial communities have accelerated the discovery of new molecular strategies for the recognition and cleavage of carbohydrates, w…
(Only some records are available in English at this moment)
The genus Xanthomonas is composed of gram-negative bacteria capable of infecting different plant species, many of them of great economic and social importance, such as rice and orange. Brazil as the second largest producer of citrus fruits in the world for decades is concerned with Citrus Canker disease, caused by the presence of the bacterium Xanthomonas citri subsp. citri, which has har…
Due to the heterogeneity and recalcitrance of lignocellulosic biomass its complete and efficient degradation is a challenge to be overcome aiming the economic viability of some bioprocesses, such as the cellulosic ethanol. One of the main factors that contribute for this is the absence of efficient and low cost enzymatic cocktails. Plant pathogens found in Xanthomonadaceae family, particu…
(Only some records are available in English at this moment)
Primary cell walls of plants are mainly composed by cellulose and hemicellulose, having xyloglucan (XyG) as the main hemicellulosic polysaccharide. The XyG structure and composition largely varies according to plant type and tissue requiring a diverse and complex repertoire of glycosyl hydrolases to be depolymerized. The genus Xanthomonas poses as one of the most widespread pathogenic bac…
Glycoside hydrolases from family 43 (GH43) act on the degradation of key polysaccharides that constitute the hemicellulose such as xylan and arabinans. However, despite this family having a strong correlation with plant cell wall deconstruction and being ubiquitous in plant biomass maceration specialized organisms, it is still poorly explored. GH43 is a very polyspecific family, divided i…
The family 5 of glycoside hydrolases (GH5) consists of more than 12000 members that recognize and hydrolyze a broad range of carbohydrates. For a better understanding of the great diversity of its enzymatic repertoire, Asperborg et al. (2012) classified the GH5 family into 51 subfamilies, from which 20 did not have available characterization data so far. In the current FAPESP doctoral pro…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 8 / 8 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 26 / 22 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 44 / 40 | All research grants and scholarships |
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