CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
NBachelors degree in Nursing from the University of Campinas (Unicamp, 1985), Masters degree in Biochemistry from Unicamp (1988), and Ph.D. in Biochemistry from the University of São Paulo (1993). Full Professor of Biochemistry at Unicamp, since 2010). Senior collaborating Professor (2019present). Has experience in Biophysics, Biochemistry, and Pharmaceutical Sciences, with a focus on the development of drug delivery systems (such as liposomes, nanostructured lipid carriers, and cyclodextrins). Her research emphasizes the study of the molecular interactions between active compounds (anticancer drugs, local anesthetics,...) and the drug delivery systems, their characterization, and biological evaluation. (Source: Lattes Curriculum)
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Breast cancer is a huge public health problem and the second most important cause of cancer deaths among women, in Brazil. Relapse and metastasis are observed in up to 30% of patients after conventional treatment and may cause death. Furthermore, conventional therapies themselves often contribute to numerous adverse effects. The development of drug delivery systems (DDS) can reduce such u…
This exchange proposal has a primary objective of establishing a collaborative international research consortium specializing in the fields of nanotechnology and bioimage analysis. We will focus on evaluating both the therapeutic and toxic effects of nanoparticles by incorporating advanced bioimage analysis techniques to propel our research endeavors forward. Through a comprehensive excha…
Nanomaterials have enormous potential to solve problems in various fields, such as agriculture, livestock, and medicine. The biological role of nanomaterials is closely related to their physicochemical properties, and because these nanomaterials interact with the environment in which they are inserted, the corona effect appears as a protagonist. An important application of nanomaterials i…
Metabolomics study the quantitative changes in low molecular weight metabolites that occur in biological samples such as biofluids, cells and tissues. Nuclear Magnetic Resonance (NMR) and Mass spectroscopy are the two main techniques in metabolomic studies. This request is intended to find the financial support for a short-time visit (14 days - from October 8th to 21rst 2023) of Iola F. D…
Metabolomics study the quantitative changes in low molecular weight metabolites that occur in biological samples such as biofluids, cells and tissues. Nuclear Magnetic Resonance (NMR) and Mass spectroscopy are the two main techniques in metabolomic studies. This request is intended to find the financial support for a short-time visit (15 days, from October 8th to 22th 2023) of Dr. Thelma …
Nanostructured lipid carriers (CLN) are suitable for the encapsulation of hydrophobic drugs, offering a series of advantages over other drug-delivery carriers such as: biocompatibility, biodegradability, non-immunogenicity, relative low cost, no requirement of organic solvents and scalability. Aiming to stablish a collaborative research network between the Biomembranes laboratory (Unicamp…
(Only some records are available in English at this moment)
Breast cancer is a major public health problem because it is the most commonly diagnosed cancer and the second leading cause of cancer-related deaths in women worldwide. In Brazil, excluding non-melanoma skin tumors, breast cancer (BC) is the most common cancer in women of all regions and, despite advances in therapy, chemotherapy based on taxanes and anthracyclines still represents the m…
Cannabigerol (CBG), a phytocannabinoid with anti-inflammatory and antioxidant properties, has been explored as a potential therapeutic agent in various neuropsychiatric conditions, including Autism Spectrum Disorder (ASD). However, its low water solubility and rapid metabolism limit its bioavailability and therapeutic efficacy. The encapsulation of CBG aims to overcome pharmacokinetic cha…
In recent years, with increasing population growth and food consumption, the use of agrochemicals for pest control has become indispensable since losses caused by pest account for approximately 20% to 40% of agricultural production. To reduce this percentage, manufacturers began to use and rely on synthetic chemical products. However, their indiscriminate and irresponsible use can harm hu…
Breast cancer is one of the most prevalent malignancies worldwide and one of the leading causes of cancer death, mainly due to metastatic events that spread the disease to other organs. Another important aspect related to the metastatic process and tumor aggressiveness is the dormancy mechanism, which keeps these neoplastic cells in a quiescent state and gives them the power to resist con…
Recently, metallic nanoparticles have emerged as a promising biotechnological system for the transport and delivery of drugs and biomolecules for a myriad biomedical application, pointing as an innovative solution to the challenges currently unmet in clinical standards. However, in contact with biological fluids, nanoparticles are quickly covered by biomacromolecules that form the biomole…
Of the malignant tumors registered in Brazil, skin cancer is the most frequent and corresponds to about 30% of the cases. Melanoma is a type of skin cancer that, despite its low incidence (3% of malignant neoplasms), is the most aggressive form of skin cancer given its high metastatic potential (mainly brain), high mortality (80%) and resistance to therapy with chemotherapeutic agents. Th…
(Only some records are available in English at this moment)
Breast cancer is the second leading cause of cancer-related deaths globally, and despite existing treatments, there remains a need to deepen understanding and refine therapeutic strategies. One promising approach is photothermal therapy (PTT), a minimally invasive treatment where photothermal agents, like gold nanoparticles, convert light into heat, raising the temperature of target tissu…
Breast cancer is the most prevalent malignancy among women and the second most common cancer globally, with tumor recurrence being a significant factor in poor patient outcomes. Despite advances in early detection and treatment, recurrence remains a major therapeutic challenge, often occurring years after initial therapy. A key mechanism underlying recurrence is tumor cell dormancy, where…
In the pharmaceutical field, several variables and processes can affect the properties and characteristics of new formulations. Therefore, the use of powerful algorithms during data analysis allows adoption of proper mathematical models as a strategy to reduce the complexity of the subject and increase our knowledge of the overall system. During this BEPE, ComDim algorithm will be used to…
Local anesthetics (AL) are drugs widely used in medical and dental clinics being capable of reversibly blocking the painful stimulus without loss of consciousness. However, in some cases AL may not have the desired effects, such as in inflamed tissues. To circumvent this situation, ALs can be encapsulated in nanostructured lipid carriers (NLC) composed of synthetic or natural excipients i…
Local anesthetics (LAs) are often used in medical practice when it is necessary to numb parts of the body. Although desirable, local anesthetics cannot guarantee the selective blockage of nociceptive fibers causing adverse reaction (motor and autonomic blockage). Recently, it was reported that the application of local anesthetic followed by capsaicin leads to a selective increase in senso…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 20 / 15 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 49 / 25 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 81 / 52 | All research grants and scholarships |
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