Electrospun Polyamide 6/Poly(allylamine hydrochloride) Nanofibers Functionalized with Carbon Nanotubes for Electrochemical Detection of Dopamine

Author(s)

Mercante, Luiza A. ^[1] ; Pavinatto, Adriana ^[1] ; Iwaki, Leonardo E. O. ^[2] ; Scagion, Vanessa P. ^{[1, 3]} ; Zucolotto, Valtencir ^[2] ; Oliveira, Jr., Osvaldo N. ^[2] ; Mattoso, Luiz H. C. ^[1] ; Correa, Daniel S. ^{[1, 3]}

Affiliation

^[1] Embrapa Instrumentat, Natl Lab Nanotechnol Agribusiness LNNA, BR-13560970 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sao Carlos Inst Phys IFSC, BR-13566590 Sao Paulo - Brazil

^[3] Fed Univ Sao Carlos UFSCar, Ctr Exact Sci & Technol, BR-13565905 Sao Paulo - Brazil

• Document type: Journal article
• Source: ACS APPLIED MATERIALS & INTERFACES; v. 7, n. 8, p. 4784-4790, MAR 4 2015.
• Web of Science Citations: 74

Abstract

The use of nanomaterials as an electroactive medium has improved the performance of bio/chemical sensors, particularly when synergy is reached upon combining distinct materials. In this paper, we report on a novel architecture comprising electrospun polyamide 6/poly(allylamine hydrochloride) (PA6/PAH) nanofibers functionalized with multiwalled carbon nanotubes, used to detect the neurotransmitter dopamine (DA). Miscibility of PA6 and PAH was sufficient to form a single phase material, as indicated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), leading to nanofibers with no beads onto which the nanotubes could adsorb strongly. Differential pulse voltammetry was employed with indium tin oxide (ITO) electrodes coated with the functionalized nanofibers for the selective electrochemical detection of dopamine (DA), with no interference from uric acid (UA) and ascorbic acid (AA) that are normally present in biological fluids. The response was linear for a DA concentration range from 1 to 70 mu mol L-1, with detection limit of 0.15 mu mol L-1 (S/N = 3). The concepts behind the novel architecture to modify electrodes can be potentially harnessed in other electrochemical sensors and biosensors. (AU)

• FAPESP's process: 14/16789-5 - Hybrid nanostructured materials based on conjugated polymers and metallic nanoparticles for sensor applications
• Grantee: Daniel Souza Corrêa
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/26712-7 - Development of nanostructured biosensors for the detection of endocrine disruptors in aquaculture
• Grantee: Adriana Pavinatto da Costa
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 12/23880-3 - Development of polymeric nanostructures as a sensor platform for diagnosis of bacteria causing mastitis
• Grantee: Luiza Amim Mercante
• Support Opportunities: Scholarships in Brazil - Post-Doctoral