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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits

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Zeraik, Maria Luiza [1] ; Queiroz, Emerson Ferreira [2] ; Marcourt, Laurence [2] ; Ciclet, Olivier [2] ; Castro-Gamboa, Ian [1] ; Siqueira Silva, Dulce Helena [1] ; Cuendet, Muriel [2] ; Bolzani, Vanderlan da Silva [1] ; Wolfender, Jean-Luc [2]
Total Authors: 9
[1] Sao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, Nucleus Bioassays Biosynth & Ecophysiol Nat Prod, POB 355, BR-14800900 Sao Paulo - Brazil
[2] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, CH-1211 Geneva 4 - Switzerland
Total Affiliations: 2
Document type: Journal article
Source: Journal of Functional Foods; v. 21, p. 396-405, MAR 2016.
Web of Science Citations: 12

The methanolic extract of umbu (Spondias tuberosa) presented high antioxidant activities in the DPPH, ABTS and ORAC assays, as well as acetylcholinesterase (AChE) inhibition activity. The dichloromethane extract exhibited cancer chemopreventive activity, with a quinone reductase induction in Hepa1c1c7 cells. The localization of the active compounds was performed by HPLC activity-based profiling, and preliminary structural information was obtained by HPLC-PAD-ESI-MS and UHPLC-TOF-HAMS. The main constituents from the methanolic extract were efficiently isolated in a single step by preparative MPLC-UV. Two new natural products were identified, together with five known compounds. The structures of the compounds were elucidated by 2D NMR and ESI-HRMS. The dichloromethane extract was fractionated by SPE and by semi-preparative HPLC-UV-ELSD. Using this approach, one anacardic acid derivative was isolated. However, this compound was not responsible for QR induction. This study highlights the potential of umbu as an active ingredient for functional food formulations. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 11/03017-6 - Natural products from plants of Cerrado and Atlantic Forest, potential models and useful for identifying prototypes with oxidizing action on neutrophils and myeloperoxidase (MPO) enzyme
Grantee:Maria Luiza Zeraik
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC