Fate of ivermectin in the terrestrial and aquatic environment: mobility, degradation, and toxicity towards Daphnia similis

Author(s)

Rath, Susanne ^[1] ; Pereira, Leandro Alves ^[1] ; Dal Bosco, Sandra Maria ^[1] ; Maniero, Milena Guedes ^[2] ; Fostier, Anne Helene ^[1] ; Guimaraes, Jose Roberto ^[2]

Affiliation

^[1] Univ Estadual Campinas, Dept Analyt Chem, Inst Chem, POB 6154, BR-13084971 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Sch Civil Engn Architecture & Urban Design, BR-13083852 Campinas, SP - Brazil

• Document type: Journal article
• Source: Environmental Science and Pollution Research; v. 23, n. 6, p. 5654-5666, MAR 2016.
• Web of Science Citations: 1

Abstract

Ivermectin (IVM) is a broad-spectrum antiparasitic drug that is regularly employed in veterinary medicine. In this work, the sorption and desorption of IVM in two Brazilian soils (N1-sand and S2-clay) as well as its leaching capacity, dissipation under aerobic conditions, and degradation in aqueous solution by photocatalysis with TiO2 in suspension were evaluated. The kinetic sorption curves of IVM were adjusted to a pseudo-second-order model. The sorption and desorption data were well fitted with the Freundlich isotherms in the log form (r > 0.96). The Freundlich sorption coefficient (K (F) (ads) ) and the Freundlich desorption coefficient (K (F) (des) ) were 77.7 and 120 mu g(1-1/n) (cm(3))(1/n) g(-1) and 74.5 and 138 mu g(1-1/n) (cm(3))(1/n) g(-1), for soils N1 and S2, respectively. A greater leaching capacity of IVM was observed for the sandy soil N1 than for the clay soil S2. Under aerobic conditions, the dissipation (DT50) at 19.3 A degrees C was 15.5 days (soil N1) and 11.5 days (soil S2). Photocatalysis with UVC and TiO2 in suspension resulted in the degradation of 98 % of IVM (500 mu g L-1) in water in 600 s. The toxicity (Daphnia similis) of the solutions submitted to the photocatalytic process was completely eliminated after 10 min. (AU)

• FAPESP's process: 13/07817-2 - Degradation of sulfonamides and tetraciclines by UV/H2O2 and O3: evaluation of antimicrobial activity and toxicity
• Grantee: Milena Guedes Maniero Ferreira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/09543-7 - Residues of veterinary drugs in the environment
• Grantee: Susanne Rath
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 09/17470-4 - SORPTION OF VETERINARY MEDICINES ON BRAZILIAN SOILS
• Grantee: Anne Helene Fostier
• Support Opportunities: Regular Research Grants