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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Minor snake venom proteins: Structure, function and potential applications

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Boldrini-Franca, Johara ; Cologna, Camila Takeno ; Pucca, Manuela Berto ; Figueiredo Bordon, Karla de Castro ; Amorim, Fernando Gobbi ; Pino Anjolette, Fernando Antonio ; Cordeiro, Francielle Almeida ; Wiezel, Gisele Adriano ; Cerni, Felipe Augusto ; Pinheiro-Junior, Ernesto Lopes ; Tanaka Shibao, Priscila Yumi ; Ferreira, Isabela Gobbo ; de Oliveira, Isadora Sousa ; Cardoso, Lara Aime ; Arantes, Eliane Candiani
Total Authors: 15
Document type: Review article
Source: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS; v. 1861, n. 4, p. 824-838, APR 2017.
Web of Science Citations: 18
Abstract

Snake venoms present a great diversity of pharmacologically active compounds that may be applied as research and biotechnological tools, as well as in drug development and diagnostic tests for certain diseases. The most abundant toxins have been extensively studied in the last decades and some of them have already been used for different purposes. Nevertheless, most of the minor snake venom protein classes remain poorly explored, even presenting potential application in diverse areas. The main difficulty in studying these proteins lies on the impossibility of obtaining sufficient amounts of them for a comprehensive investigation. The advent of more sensitive techniques in the last few years allowed the discovery of new venom components and the indepth study of some already known minor proteins. This review summarizes information regarding some structural and functional aspects of low abundant snake venom proteins classes, such as growth factors, hyaluronidases, cysteine-rich secretory proteins, nucleases and nucleotidases, cobra venom factors, vespryns, protease inhibitors, antimicrobial peptides, among others. Some potential applications of these molecules are discussed herein in order to encourage researchers to explore the full venom repertoire and to discover new molecules or applications for the already known venom components.(C) 2016 Published by Elsevier B.V. (AU)

FAPESP's process: 14/06170-8 - Biochemical and in vitro evaluation of fibroblast activation and leishmanicidal potential of an L-amino acid oxidase (LAAO) from Crotalus durissus terrificus venom
Grantee:Gisele Adriano Wiezel
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 11/12317-3 - Cloning and heterologous expression of hyaluronidase and/or novel toxins obtained from the transcriptome of Tityus serrulatus' venom gland
Grantee:Fernanda Gobbi Amorim
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/23236-4 - Native and recombinant animal toxins: functional, structural and molecular analysis
Grantee:Suely Vilela
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/16714-8 - New functional perspectives of a serine protease from Crotalus durissus collilineatus: activity on voltage-gated ion channels
Grantee:Johara Boldrini França Stringari
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 12/13590-8 - Isolation, molecular and functional characterization of a new toxin from Tityus serrulatus scorpion venom
Grantee:Felipe Augusto Cerni
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/26619-7 - Comparative proteomic study of Crotalus durissus terrificus white and yellow venoms, with emphasis on hyaluronidase and L-amino acid oxidase enzymes
Grantee:Karla de Castro Figueiredo Bordon
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 14/15644-3 - Rhinella schneideri mucous gland trascriptome
Grantee:Priscila Yumi Tanaka Shibao
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/12954-6 - Study of the toxins Ts6 e Ts15 from the scorpion Tityus serrulatus as potential therapeutic drugs for the treatment of autoimmune diseases
Grantee:Manuela Berto Pucca
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/26200-6 - Venomics Plataform of Pachycondyla villosa Proteome, Transcriptome, Cloning and Expression of toxins with biotechnological potential
Grantee:Camila Takeno Cologna
Support Opportunities: Scholarships in Brazil - Post-Doctoral