| Full text | |
| Author(s): Show less - |
Boldrini-Franca, Johara
;
Cologna, Camila Takeno
;
Pucca, Manuela Berto
;
Figueiredo Bordon, Karla de Castro
;
Amorim, Fernando Gobbi
;
Pino Anjolette, Fernando Antonio
;
Cordeiro, Francielle Almeida
;
Wiezel, Gisele Adriano
;
Cerni, Felipe Augusto
;
Pinheiro-Junior, Ernesto Lopes
;
Tanaka Shibao, Priscila Yumi
;
Ferreira, Isabela Gobbo
;
de Oliveira, Isadora Sousa
;
Cardoso, Lara Aime
;
Arantes, Eliane Candiani
Total Authors: 15
|
| Document type: | Review article |
| Source: | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS; v. 1861, n. 4, p. 824-838, APR 2017. |
| Web of Science Citations: | 18 |
| Abstract | |
Snake venoms present a great diversity of pharmacologically active compounds that may be applied as research and biotechnological tools, as well as in drug development and diagnostic tests for certain diseases. The most abundant toxins have been extensively studied in the last decades and some of them have already been used for different purposes. Nevertheless, most of the minor snake venom protein classes remain poorly explored, even presenting potential application in diverse areas. The main difficulty in studying these proteins lies on the impossibility of obtaining sufficient amounts of them for a comprehensive investigation. The advent of more sensitive techniques in the last few years allowed the discovery of new venom components and the indepth study of some already known minor proteins. This review summarizes information regarding some structural and functional aspects of low abundant snake venom proteins classes, such as growth factors, hyaluronidases, cysteine-rich secretory proteins, nucleases and nucleotidases, cobra venom factors, vespryns, protease inhibitors, antimicrobial peptides, among others. Some potential applications of these molecules are discussed herein in order to encourage researchers to explore the full venom repertoire and to discover new molecules or applications for the already known venom components.(C) 2016 Published by Elsevier B.V. (AU) | |
| FAPESP's process: | 14/06170-8 - Biochemical and in vitro evaluation of fibroblast activation and leishmanicidal potential of an L-amino acid oxidase (LAAO) from Crotalus durissus terrificus venom |
| Grantee: | Gisele Adriano Wiezel |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 11/12317-3 - Cloning and heterologous expression of hyaluronidase and/or novel toxins obtained from the transcriptome of Tityus serrulatus' venom gland |
| Grantee: | Fernanda Gobbi Amorim |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 11/23236-4 - Native and recombinant animal toxins: functional, structural and molecular analysis |
| Grantee: | Suely Vilela |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 15/16714-8 - New functional perspectives of a serine protease from Crotalus durissus collilineatus: activity on voltage-gated ion channels |
| Grantee: | Johara Boldrini França Stringari |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 12/13590-8 - Isolation, molecular and functional characterization of a new toxin from Tityus serrulatus scorpion venom |
| Grantee: | Felipe Augusto Cerni |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/26619-7 - Comparative proteomic study of Crotalus durissus terrificus white and yellow venoms, with emphasis on hyaluronidase and L-amino acid oxidase enzymes |
| Grantee: | Karla de Castro Figueiredo Bordon |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 14/15644-3 - Rhinella schneideri mucous gland trascriptome |
| Grantee: | Priscila Yumi Tanaka Shibao |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/12954-6 - Study of the toxins Ts6 e Ts15 from the scorpion Tityus serrulatus as potential therapeutic drugs for the treatment of autoimmune diseases |
| Grantee: | Manuela Berto Pucca |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/26200-6 - Venomics Plataform of Pachycondyla villosa Proteome, Transcriptome, Cloning and Expression of toxins with biotechnological potential |
| Grantee: | Camila Takeno Cologna |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |