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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Solubility of commercial octacosanol in organic solvents and their correlation by thermodynamic models at different temperatures

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Author(s):
Cuevas, Maite S. ; Crevelin, Eduardo J. ; de Moraes, Luiz A. B. ; Oliveira, Alessandra L. ; Rodrigues, Christianne E. C. ; Meirelles, Antonio J. A.
Total Authors: 6
Document type: Journal article
Source: JOURNAL OF CHEMICAL THERMODYNAMICS; v. 110, p. 186-192, JUL 2017.
Web of Science Citations: 4
Abstract

Octacosanol is a high-molar-mass primary aliphatic alcohol that has shown promising effects in diabetes treatment and in lowering cholesterol. Although this compound has been obtained from non-saponifiable matter of vegetable materials by extraction with solvents, there are no solubility data in the literature. This study presents experimental values for commercial octacosanol solubility in three pure solvents (1-pentanol, 1-hexanol, and toluene) from 298.2 to 333.2 K. Solubility obtained in this study ranges from 0.0006 to 0.0602 in mole fractions. In addition, solid-liquid equilibrium results were correlated using four thermodynamic models: Van Laar, three-suffix Margules, NRTL, and UNIQUAC. Results show that high temperatures and the use of alcoholic solvents with the longest carbon chain or hydrocarbons are required to maximize commercial octacosanol solubility. The UNIQUAC model provides the best performance in the correlation of the experimental values; however, all thermodynamic models could be used to describe commercial octacosanol solubility. (C) 2017 Elsevier Ltd. (AU)

FAPESP's process: 14/09446-4 - Development of a process of vegetable oil extraction using alcoholic solvents: evaluation of oil composition and changes in the protein fraction
Grantee:Christianne Elisabete da Costa Rodrigues
Support type: Regular Research Grants
FAPESP's process: 07/06170-4 - Solubility of rice bran oil minor compounds in organic solvents: Experimental data and modeling
Grantee:Maitê Sarria Cuevas
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/21252-0 - Equilibrium and production processes of biofuels and bioproducts
Grantee:Antonio José de Almeida Meirelles
Support type: Research Projects - Thematic Grants
FAPESP's process: 08/56258-8 - Phase equilibrium and purification processes in the production of biofuels and biocompounds
Grantee:Antonio José de Almeida Meirelles
Support type: Program for Research on Bioenergy (BIOEN) - Thematic Grants
FAPESP's process: 15/07370-3 - Preservation of Carotenoids in Oil from Palm Pressed Fiber extracted using Hexane + Alcohol Mixtures as Solvents
Grantee:Maitê Sarria Cuevas
Support type: Scholarships in Brazil - Post-Doctorate