Solubility of commercial octacosanol in organic solvents and their correlation by thermodynamic models at different temperatures

Author(s)

Cuevas, Maite S. ; Crevelin, Eduardo J. ; de Moraes, Luiz A. B. ; Oliveira, Alessandra L. ; Rodrigues, Christianne E. C. ; Meirelles, Antonio J. A.

• Document type: Journal article
• Source: JOURNAL OF CHEMICAL THERMODYNAMICS; v. 110, p. 186-192, JUL 2017.
• Web of Science Citations: 4

Abstract

Octacosanol is a high-molar-mass primary aliphatic alcohol that has shown promising effects in diabetes treatment and in lowering cholesterol. Although this compound has been obtained from non-saponifiable matter of vegetable materials by extraction with solvents, there are no solubility data in the literature. This study presents experimental values for commercial octacosanol solubility in three pure solvents (1-pentanol, 1-hexanol, and toluene) from 298.2 to 333.2 K. Solubility obtained in this study ranges from 0.0006 to 0.0602 in mole fractions. In addition, solid-liquid equilibrium results were correlated using four thermodynamic models: Van Laar, three-suffix Margules, NRTL, and UNIQUAC. Results show that high temperatures and the use of alcoholic solvents with the longest carbon chain or hydrocarbons are required to maximize commercial octacosanol solubility. The UNIQUAC model provides the best performance in the correlation of the experimental values; however, all thermodynamic models could be used to describe commercial octacosanol solubility. (C) 2017 Elsevier Ltd. (AU)

• FAPESP's process: 14/21252-0 - Equilibrium and production processes of biofuels and bioproducts
• Grantee: Antonio José de Almeida Meirelles
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/09446-4 - Development of a process of vegetable oil extraction using alcoholic solvents: evaluation of oil composition and changes in the protein fraction
• Grantee: Christianne Elisabete da Costa Rodrigues
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/07370-3 - Preservation of Carotenoids in Oil from Palm Pressed Fiber extracted using Hexane + Alcohol Mixtures as Solvents
• Grantee: Maitê Sarria Cuevas
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 07/06170-4 - Solubility of rice bran oil minor compounds in organic solvents: Experimental data and modeling
• Grantee: Maitê Sarria Cuevas
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 08/56258-8 - Phase equilibrium and purification processes in the production of biofuels and biocompounds
• Grantee: Antonio José de Almeida Meirelles
• Support Opportunities: Program for Research on Bioenergy (BIOEN) - Thematic Grants