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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gallicacid/hydroxypropyl-beta-cyclodextrin complex: Improving solubility for application on in vitro/in vivo Candida albicans biofilms

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Author(s):
Teodoro, Guilherme Rodrigues ; Lacerda Gontijo, Aline Vidal ; Borges, Aline Chiodi ; Tanaka, Marcia Hiromi ; Gouvea Lima, Gabriela de Morais ; Salvador, Marcos Jose ; Koga-Ito, Cristiane Yumi
Total Authors: 7
Document type: Journal article
Source: PLoS One; v. 12, n. 7 JUL 11 2017.
Web of Science Citations: 5
Abstract

The aim of this study was to increase the solubility of gallic acid (GA) for the treatment of Candida albicans biofilm, which is very difficult to treat and requires high drug concentrations. Cyclodextrins (CDs) were used for this purpose. Complexes were evaluated by phase-solubility studies, prepared by spray drying and characterized by drug loading, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The complexes were tested on C. albicans biofilm using in vitro and in vivo models. HP beta CD formed soluble inclusion complexes with GA. The percentage of GA in GA/HP beta CD was 10.8 +/- 0.01%. The SEM and DSC analyses confirmed the formation of inclusion complexes. GA/HP beta CD maintained the antimicrobial activity of the pure GA. GA/HP beta CD was effective on C. albicans biofilms of 24 and 48h. The in vivo results showed an anti-inflammatory activity of GA/HP beta CD with no difference in invading hypha counting among the groups. This study encourages the development of new antifungal agents. (AU)

FAPESP's process: 12/16805-5 - ANTIFUNGAL ACTIVITY OF PHENOLYIC ENRICHED FRACTION OF Buchenavia tomentosa AND SOME ISOLATED SUBSTANCES BEFORE AND AFTER ENCAPSULATION WITH BETA-CYCLODEXTRIN
Grantee:Guilherme Rodrigues Teodoro
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/13469-0 - Effects of treatment with hydroxyurea in the oral cavity of pediatric patients with sickle cell anemia
Grantee:Marcia Hiromi Tanaka
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/02354-7 - Antifungal activity and genotoxicity of atmospheric pressure nonthermal plasma jet
Grantee:Aline Chiodi Borges
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/09666-4 - DEPLOYMENT OF ASSAYS FOR EVALUATION OF BIOPHARMACEUTIC CHARACTERISTICS AND BIOACTIVITY OF COMPOUNDS AND BIOACTIVE PRODUCTS USING IN VITRO MODELS OF INVASIVE CANDIDIASIS
Grantee:Aline Vidal Lacerda Gontijo
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/03470-3 - Aplications of low temperature atmospheric pressure plasma in dentistry
Grantee:Gabriela de Morais Gouvêa Lima
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/00037-1 - Antifungal activity of phenolic enriched fraction of Buchenavia tomentosa and some isolated substances before and after encapsulation in Beta-cyclodextrin
Grantee:Cristiane Yumi Koga Ito
Support Opportunities: Regular Research Grants