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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice

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Author(s):
Batista, Angela G. [1] ; Soares, Edilene S. [2] ; Mendonca, Monique C. P. [2, 3] ; da Silva, Juliana K. [1] ; Dionisio, Ana Paula [4] ; Sartori, Cesar R. [5] ; da Cruz-Hofling, Maria Alice [2, 3] ; Marostica Junior, Mario R. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, Fac Food Engn, Dept Food & Nutr, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Dept Pharmacol, Campinas, SP - Brazil
[4] Brazilian Agr Res Corp, Embrapa Trop Agroind, Fortaleza, Ceara - Brazil
[5] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: MOLECULAR NUTRITION & FOOD RESEARCH; v. 61, n. 10 OCT 2017.
Web of Science Citations: 13
Abstract

The hyperphosphorylation of microtubule-associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as Alzheimer's disease. In this study, we used a high-fat diet to induce obesity and insulin resistance in adult Swiss mice and checked whether supplementation with Myrciaria jaboticaba berry peel for 10 weeks could improve insulin sensitivity, learning/memory performance, and prevent tau phosphorylation in the hippocampus. Furthermore, adipocytokines, inflammatory markers, and oxidative stress were assessed. Myrciaria jaboticaba peel has phenolic compounds (e.g., cyanidin, ellagic acid), dietary fiber and carotenoids, which contribute to great antioxidant capacity. Supplementation of the high-fat diet with 4% M. jaboticaba peel prevented fat weight gain and reduced peripheral insulin resistance. The treated group also showed lower tau phosphorylation in the hippocampus corroborating better learning/memory performance in the Morris water maze test. Maintenance of neuronal viability, lower levels of hippocampal inflammatory markers, and improved brain antioxidant defenses were also related to the consumption of M. jaboticaba peel. These findings contribute to a better understanding of how a high-fat diet supplemented with jaboticaba berry peel counteracts the impairment of cognitive functions caused by high-fat diet intake and diet-induced insulin resistance. (AU)

FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
Grantee:Glaucia Maria Pastore
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 10/05262-5 - The effect of freeze-dried peel jabuticaba, conjugated linoleic acid (CLA) and phytosterols on the prevention and treatment of high fat diet-induced obesity using different experimental models
Grantee:Mário Roberto Maróstica Junior
Support Opportunities: Regular Research Grants