Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Conversion of D-Fructose to 5-(Hydroxymethyl)furfural: Evaluating Batch and Continuous Flow Conditions by Design of Experiments and In-Line FTIR Monitoring

Full text
Author(s):
Galaverna, Renan [1] ; Breitkreitz, Marcia C. [1] ; Pastre, Julio C. [1]
Total Authors: 3
Affiliation:
[1] Univ Campinas UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ACS SUSTAINABLE CHEMISTRY & ENGINEERING; v. 6, n. 3, p. 4220-4230, MAR 2018.
Web of Science Citations: 12
Abstract

The dehydration reaction of D-(-)-fructose into 5-(hydroxymethyl)furfural (HMF) in both batch and continuous flow conditions was comprehensively studied using the statistical tool design of experiments (DoE), employing i-PrOH/DMSO as the solvent system in the presence of the solid acid catalyst Amberlyst-15. Initially, screening of different alcohols (MeOH, EtOH, i-PrOH, and t-BuOH) showed that i-PrOH provides better selectivity and yield compared to the other alcohols, along with minimum formation of byproducts when associated with small amounts of DMSO (15% v/v) as a cosolvent. To confirm the selectivity of the reaction, all of the possible byproducts (HMF-ethers and/or ketals) formed during the reaction between HMF and i-PrOH were synthesized. Factors like temperature, amount of DMSO, time (flow rate), and catalyst loading were evaluated by a full factorial design, and the results indicated that temperature presents the greatest influence in both batch (HMF in 71% yield) and continuous flow regime (HMF in 95% yield). In addition, a FTIR device was coupled to the continuous flow micro reactor, allowing for the first time constant in-line monitoring for this transformation, thereby showing the long-term stability of Amberlyst-15 and process robustness. (AU)

FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 06/57897-9 - Preparation, characterization and application of new stationary phases for high-performance liquid chromatography and electrochromatography
Grantee:Carol Hollingworth Collins
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes
Grantee:Carlos Roque Duarte Correia
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/05636-9 - Development of innovative analytical methods for analytes of pharmaceutical interest based on ultra-high Supercritical Fluid Chromatography associated with chemometrics tools
Grantee:Márcia Cristina Breitkreitz
Support type: Regular Research Grants
FAPESP's process: 14/26378-2 - Development of methodologies and synthetic processes employing a new technological platform: micro and meso reactor assisted synthesis of natural products and derivatives with potential pharmacological activity
Grantee:Júlio Cezar Pastre
Support type: Research Grants - Young Investigators Grants