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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Technical challenges of working with extracellular vesicles

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Author(s):
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Ramirez, Marcel I. [1, 2] ; Amorim, Maria G. [3] ; Gadelha, Catarina [4] ; Milic, Ivana [5] ; Welsh, Joshua A. [6] ; Freitas, Vanessa M. [7] ; Nawaz, Muhammad [7, 8] ; Akbar, Naveed [9] ; Couch, Yvonne [10] ; Makin, Laura [11] ; Cooke, Fiona [12] ; Vettore, Andre L. [13] ; Batista, Patricia X. [13] ; Freezor, Roberta [14] ; Pezuk, Julia A. [15] ; Rosa-Fernandes, Livia [7, 16] ; Carreira, Ana Claudia O. [7] ; Devitt, Andrew [5] ; Jacobs, Laura [17] ; Silva, Israel T. [3] ; Coakley, Gillian [18] ; Nunes, Diana N. [3] ; Carter, Dave [19] ; Palmisano, Giuseppe [7, 20] ; Dias-Neto, Emmanuel [7, 3]
Total Authors: 25
Affiliation:
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[1] Univ Fed Parana, Curitiba, Parana - Brazil
[2] Fundacao Oswaldo Cruz, Rio De Janeiro, RJ - Brazil
[3] AC Camargo Canc Ctr, CIPE, Sao Paulo, SP - Brazil
[4] Univ Nottingham, Sch Life Sci, Nottingham - England
[5] Aston Univ, Sch Life & Hlth Sci, Birmingham, W Midlands - England
[6] Univ Southampton, Southampton - England
[7] Univ Sao Paulo, Sao Paulo, SP - Brazil
[8] Univ Gothenburg, Gothenburg - Sweden
[9] Univ Oxford, Div Cardiovasc Med, Oxford - England
[10] Univ Oxford, Acute Stroke Programme, RDM Investigat Med, Oxford - England
[11] Univ Oxford, Sir William Dunn Sch Pathol, Oxford - England
[12] Univ St Andrews, St Andrews, Fife - Scotland
[13] Univ Fed Sao Paulo, Campus Diadema, Diadema - Brazil
[14] London Metropolitan Univ, London - England
[15] Univ Anhanguera Sao Paulo, Sao Paulo - Brazil
[16] Univ Southern Denmark, Odense - Denmark
[17] Tech Univ Munich, Munich - Germany
[18] Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow, Lanark - Scotland
[19] Oxford Brookes Univ, Oxford - England
[20] Fdn Santa Lucia, IRCCS, Rome - Italy
Total Affiliations: 20
Document type: Review article
Source: NANOSCALE; v. 10, n. 3, p. 881-906, JAN 21 2018.
Web of Science Citations: 64
Abstract

Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nano-sized particles transmit signals determined by their protein, lipid, nucleic acid and sugar content, and the unique molecular pattern of EVs dictates the type of signal to be transmitted to recipient cells. However, their small sizes and the limited quantities that can usually be obtained from patient-derived samples pose a number of challenges to their isolation, study and characterization. These challenges and some possible options to overcome them are discussed in this review. (AU)

FAPESP's process: 12/24574-3 - Cytokine profile in dengue virus infection: identification of potential biomarkers for diagnosis and prognosis
Grantee:Muhammad Nawaz
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/06863-3 - Post-translational modifications in cancer and parasite infection diagnosis: methodological approaches and biological implications
Grantee:Giuseppe Palmisano
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/50257-3 - Extracellular vesicles and non-cellular RNA: roles in health and neglected tropical diseases | São Paulo - SP
Grantee:Emmanuel Dias-Neto
Support type: Research Grants - Organization of Scientific Meeting
FAPESP's process: 14/26897-0 - Epidemiology and genomics of gastric adenocarcinomas in Brazil
Grantee:Emmanuel Dias-Neto
Support type: Research Projects - Thematic Grants