Epidemiology and genomics of gastric adenocarcinomas in Brazil

• Grant number: 14/26897-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: August 01, 2015
• End date: October 31, 2022
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Emmanuel Dias-Neto
• Grantee: Emmanuel Dias-Neto
• Host Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Principal investigators: Maria Paula Curado
• Associated researchers: Adriane Graicer Pelosof ; Ana Cristina Victorino Krepischi ; Daniel Diniz de Carvalho ; Danielle Queiroz Calcagno ; Diana Noronha Nunes ; Dirce Maria Carraro ; Eduardo Martín Tarazona Santos ; Elisa Napolitano e Ferreira ; Felipe José Fernandez Coimbra ; Fernando Augusto Soares ; Helano Carioca Freitas ; Israel Tojal da Silva ; João Carlos Setubal ; Jorge Estefano Santana de Souza ; Kenneth John Gollob ; Ludmilla Thomé Domingos Chinen ; Luiz Gonzaga Vaz Coelho ; Maria Dirlei Ferreira de Souza Begnami ; Maria Isabel Alves de Souza Waddington Achatz ; Michele Christine Landemberger ; Paulo Pimentel de Assumpção ; Rodrigo Drummond Couto Duarte ; Rodrigo Fernandes Ramalho ; Rommel Mario Rodríguez Burbano ; Ronaldo de Albuquerque Ribeiro ; Samia Demachki ; Sandro José de Souza ; Silvia Regina Rogatto ; Thais Fernanda Bartelli ; Tiago da Silva Medina ; Tiago Góss dos Santos ; Vilma Regina Martins ; Vinicius Fernando Calsavara ; Wilson Luiz da Costa Junior
• Associated research grant(s): 18/50013-5 - Selection of adjuvant chemotherapy for colorectal cancer patients based on methylated circulating tumor DNA, AP.R SPRINT
• Associated scholarship(s): 18/14267-2 - Characterization of the resident and transient gastric microbiota in patients with gastric adenocarcinoma, BP.MS; 16/11791-7 - Investigation of mutational signatures in gastric adenocarcinomas and evaluation of its possible prognostic impacts, BP.MS

Abstract

Gastric Adenocarcinomas (AdGs) present high mortality rates worldwide. Whereas the pathological aspects of the disease are well defined, the current knowledge status of its genesis and evolution remain to be translated to a better diagnosis or to a more effective management: the most contemporary treatment modalities available were not yet able to modify the natural history of the disease. In this sense, this project aims to contribute significantly with the knowledge of AdGs, with special emphasis in the Brazilian population. The epidemiological aspects of the disease will be revisited and combined with multidisciplinary information related to alternative etiologic agents, molecular alterations found in familial and early onset disease as well as markers of neoadjuvant chemotherapy response. The data produced here will be mined to identify factors related to prognosis and to the diversity of the histopathologic types, aiming better diagnosis and therapeutics. A collaborative network composed of medical centers from São Paulo, Fortaleza and Belém (Southeast, Northeast and North of Brazil) will be established to collect detailed epidemiological data from more than 2000 people. Our cancer center in São Paulo will collect tissues and biological fluids, which will be explored, by modern pathology techniques, metagenomics, exome and transcriptome sequencing. In the search of biomarkers we will also investigate epigenetic and structural genomic analysis, together with the study of extracellular vesicles and circulating tumor cells. All of these experiments will be evaluated in the context of the ethnical admixture, which is a particularly strong aspect of Brazilians. Our final goal is to contribute with a more effective treatment to the patients that suffer from this often lethal disease. (AU)

Scientific publications

(32)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GABRIELA PEREIRA BRANCO; RENAN VALIERIS; LUCAS VENEZIAN POVOA; LUIZA FERREIRA DE ARAÚJO; GUSTAVO RIBEIRO FERNANDES; JORGE ESTEFANO SANTANA DE SOUZA; MARIA GALLI DE AMORIM; ELISA NAPOLITANO E FERREIRA; ISRAEL TOJAL DA SILVA; DIANA NORONHA NUNES; et al. A comparison between SOLiD 5500XLand Ion Torrent PGM-derived miRNA expression profiles in two breast cell lines. GENETICS AND MOLECULAR BIOLOGY, v. 43, n. 2, 2020-04-27. (11/04399-0, 14/26897-0)

CAROLLO, EMANUELA; PARIS, BIANCA; SAMUEL, PRIYA; PANTAZI, PASCHALIA; BARTELLI, THAIS FERNANDA; DIAS-NETO, EMMANUEL; BROOKS, SUSAN ANN; PINK, RYAN CHARLES; CARTER, DAVID RAUL FRANCISCO. Detecting ovarian cancer using extracellular vesicles: progress and possibilities. BIOCHEMICAL SOCIETY TRANSACTIONS, v. 47, n. 1, p. 295-304, FEB 28 2019. (14/26897-0, 15/50257-3)

AMORIM, MARIA G.; VALIERIS, RENAN; DRUMMOND, RODRIGO D.; PIZZI, MELISSA P.; FREITAS, VANESSA M.; SINIGAGLIA-COIMBRA, RITA; CALIN, GEORGE A.; PASQUALINI, RENATA; ARAP, WADIH; SILVA, ISRAEL T.; et al. A total transcriptome profiling method for plasma-derived extracellular vesicles: applications for liquid biopsies. SCIENTIFIC REPORTS, v. 7, OCT 31 2017. (14/26897-0, 11/09172-3)

THOMAS, ANDREW MALTEZ; MANGHI, PAOLO; ASNICAR, FRANCESCO; PASOLLI, EDOARDO; ARMANINI, FEDERICA; ZOLFO, MORENO; BEGHINI, FRANCESCO; MANARA, SERENA; KARCHER, NICOLAI; POZZI, CHIARA; et al. Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation. Nature Medicine, v. 25, n. 4, p. 667+, APR 2019. (14/26897-0, 16/23527-2)

DE AMORIM, MARIA GALLI; BRANCO, GABRIELA; VALIERIS, RENAN; TARCITANO, EMILIO; DA SILVA, ISRAEL TOJAL; DE ARAUJO, LUIZA FERREIRA; NUNES, DIANA NORONHA; DIAS-NETO, EMMANUEL. The impact of HER2 overexpression on the miRNA and circRNA transcriptomes in two breast cell lines and their vesicles. PHARMACOGENOMICS, v. 20, n. 7, p. 493-502, MAY 2019. (14/26897-0, 17/20278-4, 11/04399-0)

FAGUNDES, MARCELA DE ARAUJO; CARNAUBA, RENATA ALVES; FERNANDES, GISELE APARECIDA; DE ASSUMPCAO, PAULO PIMENTEL; CURADO, MARIA PAULA. Polyphenol intake and gastric cancer: A case-control study in the Brazilian Amazon region. CANCER EPIDEMIOLOGY, v. 88, p. 7-pg., 2024-01-02. (14/26897-0)

BOBROVNITCHAIA, IRINA; VALIERIS, RENAN; DRUMMOND, RODRIGO D.; LIMA, JOAO P.; FREITAS, HELANO C.; BARTELLI, THAIS F.; DE AMORIM, MARIA G.; NUNES, DIANA N.; DIAS-NETO, EMMANUEL; DA SILVA, ISRAEL T.. APOBEC-mediated DNA alterations: A possible new mechanism of carcinogenesis in EBV-positive gastric cancer. International Journal of Cancer, v. 146, n. 1, p. 181-191, JAN 1 2020. (14/26897-0)

ROSALES, RAFAEL A.; DRUMMOND, RODRIGO D.; VALIERIS, RENAN; DIAS-NETO, EMMANUEL; DA SILVA, ISRAEL T.. signeR: an empirical Bayesian approach to mutational signature discovery. Bioinformatics, v. 33, n. 1, p. 8-16, JAN 1 2017. (14/26897-0, 15/19324-6)

PIZZI, MELISSA POOL; BARTELLI, THAIS FERNANDA; PELOSOF, ADRIANE GRAICER; FREITAS, HELANO CARIOCA; BEGNAMI, MARIA DIRLEI; SENDA DE ABRANTES, LAIS LIE; SZTOKFISZ, CLAUDIA; VALIERIS, RENAN; KNEBEL, FRANCIELE HINTERHOLZ; VAZ COELHO, LUIZ GONZAGA; et al. Identification of DNA mutations in gastric washes from gastric adenocarcinoma patients: Possible implications for liquid biopsies and patient follow-up. International Journal of Cancer, v. 145, n. 4, p. 1090-1098, AUG 15 2019. (14/26897-0)

YATES, ABI G.; PINK, RYAN C.; ERDBRUGGER, UTA; SILJANDER, PIA R-M.; DELLAR, ELIZABETH R.; PANTAZI, PASCHALIA; AKBAR, NAVEED; COOKE, WILLIAM R.; VATISH, MANU; DIAS-NETO, EMMANUEL; et al. In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo Part I: Health and Normal Physiology. JOURNAL OF EXTRACELLULAR VESICLES, v. 11, n. 1, JAN 2022. (11/09172-3, 15/50257-3, 14/26897-0)

SILVA, ALEX RICHARD COSTA; GUANDALINI, VALDETE REGINA; PEREIRA, TAISA SABRINA SILVA; ZHAO, LONGGANG; WIRTH, MICHAEL D.; HEBERT, JAMES R.; FERNANDES, GISELE APARECIDA; DE ASSUMPCAO, PAULO PIMENTEL; BARBOSA, MONICA SANTIAGO; CURADO, MARIA PAULA. Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil. NUTRIENTS, v. 15, n. 13, p. 18-pg., 2023-07-01. (14/26897-0)

BUTTURA, JAQUELINE RAMALHO; PROVISOR SANTOS, MONIZE NAKAMOTO; VALIERIS, RENAN; DRUMMOND, RODRIGO DUARTE; DEFELICIBUS, ALEXANDRE; LIMA, JOAO PAULO; CALSAVARA, VINICIUS FERNANDO; FREITAS, HELANO CARIOCA; CORDEIRO DE LIMA, VLADMIR C.; BARTELLI, THAIS FERNANDA; et al. Mutational Signatures Driven by Epigenetic Determinants Enable the Stratification of Patients with Gastric Cancer for Therapeutic Intervention. CANCERS, v. 13, n. 3, FEB 2021. (15/19324-6, 16/11791-7, 14/26897-0)

MARTIMIANAKI, GEORGIA; ALICANDRO, GIANFRANCO; PELUCCHI, CLAUDIO; BONZI, ROSSELLA; ROTA, MATTEO; HU, JINFU; JOHNSON, KENNETH C.; RABKIN, CHARLES S.; LIAO, LINDA M.; SINHA, RASHMI; et al. Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium. BRITISH JOURNAL OF CANCER, v. 127, n. 4, p. 9-pg., 2022-05-24. (14/26897-0)

DALMARTELLO, MICHELA; TURATI, FEDERICA; ZHANG, ZUO-FENG; LUNET, NUNO; ROTA, MATTEO; BONZI, ROSSELLA; GALEONE, CARLOTTA; MARTIMIANAKI, GEORGIA; PALLI, DOMENICO; FERRARONI, MONICA; et al. Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project. BRITISH JOURNAL OF CANCER, v. 126, n. 12, p. 10-pg., 2022-02-24. (14/26897-0)

BRANCO, GABRIELA PEREIRA; VALIERIS, RENAN; POVOA, LUCAS VENEZIAN; DE ARAUJO, LUIZA FERREIRA; FERNANDES, GUSTAVO RIBEIRO; SANTANA DE SOUZA, JORGE ESTEFANO; DE AMORIM, MARIA GALLI; NAPOLITANO E FERREIRA, ELISA; DA SILVA, ISRAEL TOJAL; NUNES, DIANA NORONHA; et al. A comparison between SOLiD 5500XL-and Ion Torrent PGM-derived miRNA expression profiles in two breast cell lines. GENETICS AND MOLECULAR BIOLOGY, v. 43, n. 2, 2020. (11/04399-0, 14/26897-0)

SASSANO, MICHELE; MARIANI, MARCO; PELUCCHI, CLAUDIO; LUNET, NUNO; MORAIS, SAMANTHA; MARTIN, VICENTE; MORENO, VICTOR; CURADO, MARIA PAULA; DIAS-NETO, EMMANUEL; LEJA, MARCIS; et al. Intake of Proton-Pump Inhibitors and Gastric Cancer within the Stomach Cancer Pooling (StoP) Project. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v. 32, n. 9, p. 8-pg., 2023-09-01. (14/26897-0)

FAGUNDES, MARCELA A.; PERES, V, STELA; ASSUMPCAO, PAULO P.; CURADO, MARIA P.. Physical activity and gastric cancer risk: a case-control study in the Amazon region of Brazil. European Journal of Cancer Prevention, v. 30, n. 6, p. 437-441, NOV 2021. (14/26897-0)

TIENGO, TATIANE; FERNANDES, GISELE APARECIDA; CURADO, MARIA PAULA. Gastric adenocarcinoma: 1-year overall survival, disability-adjusted life years, years of life lost, and prognostic factors-a single-institution experience. FRONTIERS IN ONCOLOGY, v. 12, p. 15-pg., 2022-09-08. (14/26897-0)

VALIERIS, RENAN; AMARO, LUCAS; BUENO DE TOLEDO OSORIO, CYNTHIA APARECIDA; BUENO, ADRIANA PASSOS; ROSALES MITROWSKY, RAFAEL ANDRES; CARRARO, DIRCE MARIA; NUNES, DIANA NORONHA; DIAS-NETO, EMMANUEL; DA SILVA, ISRAEL TOJAL. Deep Learning Predicts Underlying Features on Pathology Images with Therapeutic Relevance for Breast and Gastric Cancer. CANCERS, v. 12, n. 12, DEC 2020. (15/19324-6, 14/26897-0)

AMORIM, MARIA G.; DIAS-NETO, EMMANUEL; NUNES, DIANA N.; SPADA, S; GALLUZZI, L. Deciphering the total RNA content of extracellular vesicles. EXTRACELLULAR VESICLES, v. 645, p. 14-pg., 2020-01-01. (11/09172-3, 14/26897-0)

SANTOS, LUANA B. C.; BARTELLI, THAIS F.; NUNES, DIANA N.; DIAS-NETO, EMMANUEL. EBV and further emerging directions towards increased precision in gastric cancer treatment. TRANSLATIONAL CANCER RESEARCH, v. 11, n. 9, p. 3-pg., 2022-09-05. (14/26897-0)

ABDALLAH, EMNE A.; BRAUN, ALEXCIA C.; FLORES, BIANCA C. T. C. P.; SENDA, LAIS; URVANEGIA, ANA CLAUDIA; CALSAVARA, VINICIUS; FONSECA DE JESUS, VICTOR HUGO; ARRUDA ALMEIDA, MARIA FERNANDA; BEGNAMI, MARIA DIRLEI; COIMBRA, FELIPE J. F.; et al. The Potential Clinical Implications of Circulating Tumor Cells and Circulating Tumor Microemboli in Gastric Cancer. ONCOLOGIST, v. 24, n. 9, p. E854-E863, SEP 2019. (14/26897-0, 15/16952-6)

FERNANDEZ COIMBRA, FELIPE JOSE; DE JESUS, VICTOR HUGO F.; RIBEIRO, HEBER S. C.; DINIZ, ALESSANDRO L.; DE GODOY, ANDRE LUIS; DE FARIAS, IGOR CORREIA; FELISMINO, TIAGO; MELLO, CELSO A. L.; ALMEIDA, MARIA FERNANDA; BEGNAMI, MARIA DIRLEI F. S.; et al. Impact of ypT, ypN, and Adjuvant Therapy on Survival in Gastric Cancer Patients Treated with Perioperative Chemotherapy and Radical Surgery. ANNALS OF SURGICAL ONCOLOGY, v. 26, n. 11, p. 3618-3626, OCT 2019. (14/26897-0)

RAMIREZ, MARCEL I.; AMORIM, MARIA G.; GADELHA, CATARINA; MILIC, IVANA; WELSH, JOSHUA A.; FREITAS, VANESSA M.; NAWAZ, MUHAMMAD; AKBAR, NAVEED; COUCH, YVONNE; MAKIN, LAURA; et al. Technical challenges of working with extracellular vesicles. NANOSCALE, v. 10, n. 3, p. 881-906, JAN 21 2018. (14/26897-0, 12/24574-3, 14/06863-3, 15/50257-3)

FAGUNDES, MARCELA DE ARAUJO; SILVA, ALEX RICHARD COSTA; FERNANDES, GISELE APARECIDA; CURADO, MARIA PAULA. Dietary Polyphenol Intake and Gastric Cancer: A Systematic Review and Meta-Analysis. CANCERS, v. 14, n. 23, p. 21-pg., 2022-12-01. (14/26897-0)

COLLATUZZO, GIULIA; NEGRI, EVA; PELUCCHI, CLAUDIO; BONZI, ROSSELLA; TURATI, FEDERICA; RABKIN, CHARLES S.; LIAO, LINDA M.; SINHA, RASHMI; PALLI, DOMENICO; FERRARONI, MONICA; et al. Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium. NUTRIENTS, v. 15, n. 8, p. 13-pg., 2023-04-01. (14/26897-0)

BHANDARI, MANOHAR PRASAD; POLAKA, INESE; VANGRAVS, REINIS; MEZMALE, LINDA; VELIKS, VIKTORS; KIRSHNERS, ARNIS; MOCHALSKI, PAWEL; DIAS-NETO, EMMANUEL; LEJA, MARCIS. Volatile Markers for Cancer in Exhaled Breath-Could They Be the Signature of the Gut Microbiota?. Molecules, v. 28, n. 8, p. 20-pg., 2023-04-01. (14/26897-0)

SILVA, ALEX RICHARD COSTA; ALICANDRO, GIANFRANCO; GUANDALINI, VALDETE REGINA; GRILI, PATRICIA PAULA DA FONSECA; ASSUMPCAO, PAULO PIMENTEL; BARBOSA, MONICA SANTIAGO; DE SANT'ANA, ROSANE OLIVEIRA; COIMBRA, FELIPE JOSE FERNANDEZ; CURADO, MARIA PAULA. Exploring the link between dietary patterns and gastric adenocarcinoma in Brazil: a mediation analysis. BMC MEDICINE, v. 22, n. 1, p. 12-pg., 2024-11-28. (14/26897-0)

DE ALBUQUERQUE, GABRIELA E.; MODA, BRUNO S.; SERPA, MARIANNA S.; BRANCO, GABRIELA P.; DEFELICIBUS, ALEXANDRE; TAKENAKA, ISABELLA K. T. M.; DE AMORIM, MARIA G.; MIOLA, ELIZABETH C.; MARTINS, VALQUIRIA C. A.; TORRES, KATIA L.; et al. Evaluation of Bacteria and Fungi DNA Abundance in Human Tissues. GENES, v. 13, n. 2, p. 11-pg., 2022-02-01. (18/02972-3, 14/26897-0, 18/14267-2)

CAROLLO, EMANUELA; PARIS, BIANCA; SAMUEL, PRIYA; PANTAZI, PASCHALIA; BARTELLI, THAIS FERNANDA; DIAS-NETO, EMMANUEL; BROOKS, SUSAN ANN; PINK, RYAN CHARLES; CARTER, DAVID RAUL FRANCISCO. Detecting ovarian cancer using extracellular vesicles: progress and possibilities. BIOCHEMICAL SOCIETY TRANSACTIONS, v. 47, p. 10-pg., 2019-02-28. (15/50257-3, 14/26897-0)

YATES, ABI G.; PINK, RYAN C.; ERDBRUGGER, UTA; SILJANDER, PIA R-M.; DELLAR, ELIZABETH R.; PANTAZI, PASCHALIA; AKBAR, NAVEED; COOKE, WILLIAM R.; VATISH, MANU; DIAS-NETO, EMMANUEL; et al. n sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo Part II: Patholog. JOURNAL OF EXTRACELLULAR VESICLES, v. 11, n. 1, JAN 2022. (14/26897-0, 15/50257-3, 11/09172-3)

RAMOS, AMANDA FERREIRA PAES LANDIM; SANTIAGO, SILVANA BARBOSA; DE SOUSA MORAES, FELIPE AUGUSTO; SOARES, GIOVANA ALICE SAMPAIO; FERNANDES, GISELE APARECIDA; CURADO, MARIA PAULA; GERMANO, JANAINA NAIARA; BARBOSA, MONICA SANTIAGO. Systemic Impact of Helicobacter pylori: A Cross-Sectional Study. JGH OPEN, v. 9, n. 10, p. 10-pg., 2025-10-21. (14/26897-0)