Advanced search
Start date
Betweenand

Epidemiology and genomics of gastric adenocarcinomas in Brazil

Grant number: 14/26897-0
Support type:Research Projects - Thematic Grants
Duration: August 01, 2015 - July 31, 2021
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Emmanuel Dias-Neto
Grantee:Emmanuel Dias-Neto
Home Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
Co-Principal Investigators:Maria Paula Curado
Assoc. researchers: Adriane Graicer Pelosof ; Ana Cristina Victorino Krepischi ; Daniel Diniz de Carvalho ; Danielle Queiroz Calcagno ; Diana Noronha Nunes ; Dirce Maria Carraro ; Eduardo Martín Tarazona Santos ; Elisa Napolitano e Ferreira ; Felipe José Fernandez Coimbra ; Fernando Augusto Soares ; Helano Carioca Freitas ; Israel Tojal da Silva ; João Carlos Setubal ; Jorge Estefano Santana de Souza ; Kenneth John Gollob ; Ludmilla Thomé Domingos Chinen ; Luiz Gonzaga Vaz Coelho ; Maria Dirlei Ferreira de Souza Begnami ; Maria Isabel Alves de Souza Waddington Achatz ; Michele Christine Landemberger ; Paulo Pimentel de Assumpção ; Rodrigo Drummond Couto Duarte ; Rodrigo Fernandes Ramalho ; Rommel Mario Rodríguez Burbano ; Ronaldo de Albuquerque Ribeiro ; Samia Demachki ; Sandro José de Souza ; Silvia Regina Rogatto ; Thais Fernanda Bartelli ; Tiago da Silva Medina ; Tiago Góss dos Santos ; Vilma Regina Martins ; Vinicius Fernando Calsavara ; Wilson Luiz da Costa Junior
Associated grant(s):18/50013-5 - Selection of adjuvant chemotherapy for colorectal cancer patients based on methylated circulating tumor DNA, AP.R SPRINT
Associated scholarship(s):19/13036-0 - Interrelation study between the consumption of lipids, proteins and vitamins and the microbiota of stomach fluids in patients with gastric cancer, BP.MS
18/14267-2 - Characterization of the resident and transient gastric microbiota in patients with gastric adenocarcinoma, BP.MS
16/11791-7 - Investigation of mutational signatures in gastric adenocarcinomas and evaluation of its possible prognostic impacts, BP.MS

Abstract

Gastric Adenocarcinomas (AdGs) present high mortality rates worldwide. Whereas the pathological aspects of the disease are well defined, the current knowledge status of its genesis and evolution remain to be translated to a better diagnosis or to a more effective management: the most contemporary treatment modalities available were not yet able to modify the natural history of the disease. In this sense, this project aims to contribute significantly with the knowledge of AdGs, with special emphasis in the Brazilian population. The epidemiological aspects of the disease will be revisited and combined with multidisciplinary information related to alternative etiologic agents, molecular alterations found in familial and early onset disease as well as markers of neoadjuvant chemotherapy response. The data produced here will be mined to identify factors related to prognosis and to the diversity of the histopathologic types, aiming better diagnosis and therapeutics. A collaborative network composed of medical centers from São Paulo, Fortaleza and Belém (Southeast, Northeast and North of Brazil) will be established to collect detailed epidemiological data from more than 2000 people. Our cancer center in São Paulo will collect tissues and biological fluids, which will be explored, by modern pathology techniques, metagenomics, exome and transcriptome sequencing. In the search of biomarkers we will also investigate epigenetic and structural genomic analysis, together with the study of extracellular vesicles and circulating tumor cells. All of these experiments will be evaluated in the context of the ethnical admixture, which is a particularly strong aspect of Brazilians. Our final goal is to contribute with a more effective treatment to the patients that suffer from this often lethal disease. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
The importance of the human oral microbiome 

Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOBROVNITCHAIA, IRINA; VALIERIS, RENAN; DRUMMOND, RODRIGO D.; LIMA, JOAO P.; FREITAS, HELANO C.; BARTELLI, THAIS F.; DE AMORIM, MARIA G.; NUNES, DIANA N.; DIAS-NETO, EMMANUEL; DA SILVA, ISRAEL T. APOBEC-mediated DNA alterations: A possible new mechanism of carcinogenesis in EBV-positive gastric cancer. International Journal of Cancer, v. 146, n. 1, p. 181-191, JAN 1 2020. Web of Science Citations: 0.
GABRIELA PEREIRA BRANCO; RENAN VALIERIS; LUCAS VENEZIAN POVOA; LUIZA FERREIRA DE ARAÚJO; GUSTAVO RIBEIRO FERNANDES; JORGE ESTEFANO SANTANA DE SOUZA; MARIA GALLI DE AMORIM; ELISA NAPOLITANO E FERREIRA; ISRAEL TOJAL DA SILVA; DIANA NORONHA NUNES; EMMANUEL DIAS-NETO. A comparison between SOLiD 5500XLand Ion Torrent PGM-derived miRNA expression profiles in two breast cell lines. GENETICS AND MOLECULAR BIOLOGY, v. 43, n. 2, p. -, 2020.
BRANCO, GABRIELA PEREIRA; VALIERIS, RENAN; POVOA, LUCAS VENEZIAN; DE ARAUJO, LUIZA FERREIRA; FERNANDES, GUSTAVO RIBEIRO; SANTANA DE SOUZA, JORGE ESTEFANO; DE AMORIM, MARIA GALLI; NAPOLITANO E FERREIRA, ELISA; DA SILVA, ISRAEL TOJAL; NUNES, DIANA NORONHA; DIAS-NETO, EMMANUEL. A comparison between SOLiD 5500XL-and Ion Torrent PGM-derived miRNA expression profiles in two breast cell lines. GENETICS AND MOLECULAR BIOLOGY, v. 43, n. 2 2020. Web of Science Citations: 0.
FERNANDEZ COIMBRA, FELIPE JOSE; DE JESUS, VICTOR HUGO F.; RIBEIRO, HEBER S. C.; DINIZ, ALESSANDRO L.; DE GODOY, ANDRE LUIS; DE FARIAS, IGOR CORREIA; FELISMINO, TIAGO; MELLO, CELSO A. L.; ALMEIDA, MARIA FERNANDA; BEGNAMI, MARIA DIRLEI F. S.; DIAS-NETO, EMMANUEL; RIECHELMANN, RACHEL S. P.; DA COSTA JR, WILSON L. Impact of ypT, ypN, and Adjuvant Therapy on Survival in Gastric Cancer Patients Treated with Perioperative Chemotherapy and Radical Surgery. ANNALS OF SURGICAL ONCOLOGY, v. 26, n. 11, p. 3618-3626, OCT 2019. Web of Science Citations: 1.
ABDALLAH, EMNE A.; BRAUN, ALEXCIA C.; FLORES, BIANCA C. T. C. P.; SENDA, LAIS; URVANEGIA, ANA CLAUDIA; CALSAVARA, VINICIUS; FONSECA DE JESUS, VICTOR HUGO; ARRUDA ALMEIDA, MARIA FERNANDA; BEGNAMI, MARIA DIRLEI; COIMBRA, FELIPE J. F.; DA COSTA JR, WILSON LUIZ; NUNES, DIANA NORONHA; DIASNETO, EMMANUEL; DOMINGOS CHINEN, LUDMILLA T. The Potential Clinical Implications of Circulating Tumor Cells and Circulating Tumor Microemboli in Gastric Cancer. ONCOLOGIST, v. 24, n. 9, p. E854-E863, SEP 2019. Web of Science Citations: 2.
PIZZI, MELISSA POOL; BARTELLI, THAIS FERNANDA; PELOSOF, ADRIANE GRAICER; FREITAS, HELANO CARIOCA; BEGNAMI, MARIA DIRLEI; SENDA DE ABRANTES, LAIS LIE; SZTOKFISZ, CLAUDIA; VALIERIS, RENAN; KNEBEL, FRANCIELE HINTERHOLZ; VAZ COELHO, LUIZ GONZAGA; DA COSTA, WILSON LUIZ; COIMBRA, FELIPE J. F.; DA SILVA, ISRAEL TOJAL; DE AMORIM, MARIA GALLI; NUNES, DIANA NORONHA; DIAS-NETO, EMMANUEL. Identification of DNA mutations in gastric washes from gastric adenocarcinoma patients: Possible implications for liquid biopsies and patient follow-up. International Journal of Cancer, v. 145, n. 4, p. 1090-1098, AUG 15 2019. Web of Science Citations: 3.
DE AMORIM, MARIA GALLI; BRANCO, GABRIELA; VALIERIS, RENAN; TARCITANO, EMILIO; DA SILVA, ISRAEL TOJAL; DE ARAUJO, LUIZA FERREIRA; NUNES, DIANA NORONHA; DIAS-NETO, EMMANUEL. The impact of HER2 overexpression on the miRNA and circRNA transcriptomes in two breast cell lines and their vesicles. PHARMACOGENOMICS, v. 20, n. 7, p. 493-502, MAY 2019. Web of Science Citations: 0.
THOMAS, ANDREW MALTEZ; MANGHI, PAOLO; ASNICAR, FRANCESCO; PASOLLI, EDOARDO; ARMANINI, FEDERICA; ZOLFO, MORENO; BEGHINI, FRANCESCO; MANARA, SERENA; KARCHER, NICOLAI; POZZI, CHIARA; GANDINI, SARA; SERRANO, DAVIDE; TARALLO, SONIA; FRANCAVILLA, ANTONIO; GALLO, GAETANO; TROMPETTO, MARIO; FERRERO, GIULIO; MIZUTANI, SAYAKA; SHIROMA, HIROTSUGU; SHIBA, SATOSHI; SHIBATA, TATSUHIRO; YACHIDA, SHINICHI; YAMADA, TAKUJI; WIRBEL, JAKOB; SCHROTZ-KING, PETRA; ULRICH, CORNELIA M.; BRENNER, HERMANN; ARUMUGAM, MANIMOZHIYAN; BORK, PEER; ZELLER, GEORG; CORDERO, FRANCESCA; DIAS-NETO, EMMANUEL; SETUBAL, JOAO CARLOS; TETT, ADRIAN; PARDINI, BARBARA; RESCIGNO, MARIA; WALDRON, LEVI; NACCARATI, ALESSIO; SEGATA, NICOLA. Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation. Nature Medicine, v. 25, n. 4, p. 667+, APR 2019. Web of Science Citations: 24.
CAROLLO, EMANUELA; PARIS, BIANCA; SAMUEL, PRIYA; PANTAZI, PASCHALIA; BARTELLI, THAIS FERNANDA; DIAS-NETO, EMMANUEL; BROOKS, SUSAN ANN; PINK, RYAN CHARLES; CARTER, DAVID RAUL FRANCISCO. Detecting ovarian cancer using extracellular vesicles: progress and possibilities. BIOCHEMICAL SOCIETY TRANSACTIONS, v. 47, n. 1, p. 295-304, FEB 28 2019. Web of Science Citations: 2.
RAMIREZ, MARCEL I.; AMORIM, MARIA G.; GADELHA, CATARINA; MILIC, IVANA; WELSH, JOSHUA A.; FREITAS, VANESSA M.; NAWAZ, MUHAMMAD; AKBAR, NAVEED; COUCH, YVONNE; MAKIN, LAURA; COOKE, FIONA; VETTORE, ANDRE L.; BATISTA, PATRICIA X.; FREEZOR, ROBERTA; PEZUK, JULIA A.; ROSA-FERNANDES, LIVIA; CARREIRA, ANA CLAUDIA O.; DEVITT, ANDREW; JACOBS, LAURA; SILVA, ISRAEL T.; COAKLEY, GILLIAN; NUNES, DIANA N.; CARTER, DAVE; PALMISANO, GIUSEPPE; DIAS-NETO, EMMANUEL. Technical challenges of working with extracellular vesicles. NANOSCALE, v. 10, n. 3, p. 881-906, JAN 21 2018. Web of Science Citations: 64.
AMORIM, MARIA G.; VALIERIS, RENAN; DRUMMOND, RODRIGO D.; PIZZI, MELISSA P.; FREITAS, VANESSA M.; SINIGAGLIA-COIMBRA, RITA; CALIN, GEORGE A.; PASQUALINI, RENATA; ARAP, WADIH; SILVA, ISRAEL T.; DIAS-NETO, EMMANUEL; NUNES, DIANA N. A total transcriptome profiling method for plasma-derived extracellular vesicles: applications for liquid biopsies. SCIENTIFIC REPORTS, v. 7, OCT 31 2017. Web of Science Citations: 13.
ROSALES, RAFAEL A.; DRUMMOND, RODRIGO D.; VALIERIS, RENAN; DIAS-NETO, EMMANUEL; DA SILVA, ISRAEL T. signeR: an empirical Bayesian approach to mutational signature discovery. Bioinformatics, v. 33, n. 1, p. 8-16, JAN 1 2017. Web of Science Citations: 19.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.