Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment

Author(s):Show less -

Floriano, Juliana Ferreira ^{[1, 2]} ; de Barros, Natan Roberto ^{[3, 4, 5]} ; Ferreira Cinman, Jose Luiz ^[6] ; da Silva, Rosangela Goncalves ^{[3, 4]} ; Loffredo, Augusto Villela ^[6] ; Borges, Felipe Azevedo ^{[3, 4]} ; Queiros Norberto, Ana Maria ^[7] ; Destro Chagas, Ana Laura ^[8] ; Garms, Bruna Cambraia ^{[3, 4]} ; de Oliveira Graeff, Carlos Frederico ^[1] ; Herculano, Rondinelli Donizetti ^[3]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Sci, 14-01 Engn Luiz Edmundo Carrijo Coube Ave, BR-17033360 Bauru - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Sci, Dept Phys, 14-01 Engn Luiz Edmundo Carrijo Coube Ave, BR-17033360 Bauru - Brazil

^[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Km 01, Araraquara Jau Rd, BR-14801902 Araraquara - Brazil

^[4] Sao Paulo State Univ UNESP, Inst Chem, 55 Prof Francisco Degni St, BR-14800900 Araraquara - Brazil

^[5] Sao Paulo State Univ UNESP, Inst Chem, Pharmaceut Sci Ctr, 55 Prof Francisco Degni St, BR-14800900 Araraquara - Brazil

^[6] Sao Paulo State Univ UNESP, Sch Sci Humanities & Languages, 2100 Dom Antonio Ave, BR-19806900 Assis - Brazil

^[7] Sao Paulo Univ USP, Fac Med, 3900 Bandeirantes Ave, BR-14040900 Ribeirao Preto - Brazil

^[8] UFTM ICBN, Biochem Sect, 330 Manoel Mendes Sq, BR-38015050 Uberaba, MG - Brazil

• Document type: Journal article
• Source: JOURNAL OF POLYMERS AND THE ENVIRONMENT; v. 26, n. 6, p. 2281-2289, JUN 2018.
• Web of Science Citations: 5

Abstract

Ketoprofen is an analgesic with potent anti-inflammatory activity against acute inflammation, subacute inflammation, for the acute and long-term treatment of various inflammatory pathologies, as rheumatoid arthritis and colonic adenocarcinoma. In order to minimize the incidence of systemic events related to ketoprofen, the transdermal drug delivery system development has been most important. The advantages of using natural rubber latex membranes include not only the reduction of adverse systemic events, but also the suitability of the low cost of the material together with its physicochemical properties such as flexibility, mechanical stability, surface porosity and water vapor permeability, and besides being a biocompatible material also presents biological activity to stimulate the angiogenesis, being able to be used in tissue repair. This study demonstrated that ketoprofen was successfully incorporated into natural latex membranes for drug delivery. FTIR indicated that the drug did not interact chemically with the membrane. Moreover, the natural latex membranes released 60% of the ketoprofen incorporated in 50 h. SEM images indicated that a portion of the drug was present on the membrane surface, being this portion responsible for the burst release. The tensile tests showed that the addition of the drug into the natural latex membrane did not influence on the polymer mechanical behavior. In addition, drug-natural latex membranes presented no red blood cell damaging effects. Our data shows that the ketoprofen loaded natural latex membranes is a promising system for sustained drug delivery which can be used to minimize the adverse side effects of high dose systemic drug delivery. (AU)

• FAPESP's process: 14/17526-8 - Development of a novel system employing natural rubber latex as releasing of vegetable extracts incorporated with nanoparticles: physical chemical and biological characterization
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants