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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Role of Inflammation and Immune Cells in Blood Flow Restriction Training Adaptation: A Review

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Rossi, Fabricio Eduardo [1] ; de Freitas, Marcelo Conrado [2] ; Zanchi, Nelo Eidy [3] ; Lira, Fabio Santos [1] ; Cholewa, Jason M. [4]
Total Authors: 5
[1] Sao Paulo State Univ UNESP, Dept Phys Educ, Exercise & Immunometab Res Grp, Presidente Prudente - Brazil
[2] Sao Paulo State Univ, Sch Sci & Technol, Dept Phys Educ, Skeletal Muscle Assessment Lab, Presidente Prudente - Brazil
[3] Fed Univ Maranhao UFMA, Dept Phys Educ, Lab Cellular & Mol Biol Skeletal Muscle LABCEMME, Sao Luis - Brazil
[4] Coastal Carolina Univ, Dept Kinesiol, Conway, SC - USA
Total Affiliations: 4
Document type: Review article
Source: FRONTIERS IN PHYSIOLOGY; v. 9, OCT 9 2018.
Web of Science Citations: 1

Blood flow restriction (BFR) combined with low-intensity strength training has been shown to increase skeletal muscle mass and strength in a variety of populations. BFR results in a robust metabolic stress which is hypothesized to induce muscle growth via increased recruitment of fast-twitch muscle fibers, a greater endocrine response, and/or enhancing the cellular swelling contribution to the hypertrophic process. Following exercise, neutrophils are the first immune cells to initiate the tissue remodeling process via several mechanisms including an increased production of cytokines and recruitment of monocytes/macrophages, which facilitate the phagocytosis of foreign particles, the differentiation of myoblasts, and the formation of new myotubes. Thus, the purpose of this review was to discuss the mechanisms through which metabolic stress and immune cell recruitment may induce skeletal muscle remodeling following BFR strength training. (AU)

FAPESP's process: 15/23910-8 - Skeletal muscle remodeling induced by blood flow restriction plus low-intensity strength training: the role neutrophils/macrophages recruitment
Grantee:Fabrício Eduardo Rossi
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/16712-8 - BDNF involvement in the function of lymphocytes of sedentary obese and trained: relationship with cognitive
Grantee:Fábio Santos de Lira
Support type: Regular Research Grants