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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NF kappa B and macrophage release of IL-1 beta

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Author(s):
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Ruiz-Miyazawa, Kenji W. [1] ; Borghi, Sergio M. [1] ; Pinho-Ribeiro, Felipe A. [1] ; Staurengo-Ferrari, Larissa [1] ; Fattori, Victor [1] ; Fernandes, Glaura S. A. [2] ; Casella, Antonio M. [3] ; Alves-Filho, Jose C. [4] ; Cunha, Thiago M. [4] ; Cunha, Fernando Q. [4] ; Casagrande, Rubia [5] ; Verri, Jr., Waldiceu A. [1]
Total Authors: 12
Affiliation:
[1] Univ Estadual Londrina, Dept Ciencias Patol, Rodovia Celso Garcia Cid, Km 380, PR445, BR-86057970 Londrina, Parana - Brazil
[2] Univ Estadual Londrina, Dept Biol Geral, Rodovia Celso Garcia Cid, Km 380, PR445, BR-86057970 Londrina, Parana - Brazil
[3] Univ Estadual Londrina, Hosp Univ, Ctr Ciencias Saude, Dept Clin Med, Ave Robert Koch 60, BR-86038350 Londrina, Parana - Brazil
[4] Univ Sao Paulo, Escola Med Ribeirao Preto, Dept Farmacol, Ave Bandeirantes S-N, BR-14050490 Ribeirao Preto, SP - Brazil
[5] Univ Estadual Londrina, Hosp Univ, Dept Ciencias Farmaceut, Ave Robert Koch 60, BR-86038350 Londrina, Parana - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Functional Foods; v. 48, p. 106-116, SEP 2018.
Web of Science Citations: 1
Abstract

The effects and mechanisms of the citrus flavonoid naringenin were investigated in a mouse model of gout arthritis induced by intra-articular injection of monosodium urate crystals (MSU). Mice were treated with naringenin (16.7-150 mg/kg, per oral) 1 h before MSU (100 mu g/kg, i.a.) stimulus. MSU induced joint pain and edema, which were inhibited by naringenin at the dose of 150 mg/kg, without inducing liver and kidney toxicity. Naringenin inhibited MSU-induced histopathological changes, leukocyte recruitment, cytokine production, oxidative stress, NF kappa B activation, NLRP3 inflammasome components mRNA expression, and IL-1 beta maturation in cultured macrophages. The present data support the therapeutic applicability of naringenin in the treatment of gout arthritis. (AU)

FAPESP's process: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases
Grantee:Fernando de Queiroz Cunha
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 11/19670-0 - Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis
Grantee:Fernando de Queiroz Cunha
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 10/15014-9 - Evaluation of the effect of 15d-PGJ2-loaded on polymeric biodegradable nanoparticles to control the evolution of the experimental periodontal disease
Grantee:Marcelo Henrique Napimoga
Support Opportunities: Regular Research Grants