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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of Pluronic F127 microenvironments on the photochemical nitric oxide release from S-nitrosoglutathione

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Author(s):
Picheth, Guilherme F. [1] ; Marini, Thatiane C. [1] ; Taladriz-Blanco, Patricia [1, 2] ; Shimamoto, Gustavo G. [1] ; dos Santos, Giovanna J. V. P. [1] ; Meneau, Florian [3] ; de Oliveira, Marcelo G. [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Inst Chem, UNICAMP, CP 6154, BR-13083970 Campinas, SP - Brazil
[2] Adolphe Merkle Inst, Chemin Verdiers 4, CH-1700 Fribourg - Switzerland
[3] Brasilian Synchroton Light Lab, LNLS, CP 6192, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Colloid and Interface Science; v. 544, p. 217-229, MAY 15 2019.
Web of Science Citations: 1
Abstract

Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) (F127) hydrogels have been used to deliver nitric oxide (NO) topically in biomedical applications. Here, the effect of F127 microenvironments on the photochemical NO release from S-nitrosoglutathione (GSNO) was investigated in F127 solutions 7.6 wt% 15 wt% and 22.5 wt% at 15 degrees C and 37 degrees C. Small-angle X-ray Scattering (SAXS) and Differential Scanning Calorimetry (DSC) measurements, along with proton Nuclear Magnetic Resonance (H-1 NMR) spectral shifts and T-2 relaxation data at six different concentration-temperature conditions, allowed identifying F127 microphases characterized by: a sol phase of unimers; micelles in non-defined periodic order, and a gel phase of cubic packed micelles. Kinetic measurements showed that GSNO photodecompositon proceeds faster in micellized F127 where GSNO is segregated to the intermicellar microenvironment. Real time kinetic monitoring of NO release and T-2 relaxation profiles showed that NO is preferentially partitioned into the hydrophobic PPO cores of the F127 micelles, with the consequent decrease in its rate of release to the gas phase. These results show that F127 microphases affect both the kinetics of GSNO photodecomposition and the rate of NO escape and can be used to modulate the photochemical NO delivery from F127/GSNO solutions. (C) 2019 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release
Grantee:Marcelo Ganzarolli de Oliveira
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/19253-7 - Pluronic F127 thermosensitive hydrogels functionalized with terminal groups releasing nitric oxide
Grantee:Guilherme Fadel Picheth
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/03266-4 - PVA-F-127 thermosensitive nanocarriers for the photochemical nitric oxide release
Grantee:Thatiane Cristine Camargo Marini
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 17/04615-0 - Nitric oxide releasing collagen membranes for bone regeneration
Grantee:Giovanna Jardim Vieira Pereira dos Santos
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/07173-8 - Nanoparticles and hydrogels for the photochemical delivery of nitric oxide
Grantee:Patricia Taladriz Blanco
Support Opportunities: Scholarships in Brazil - Post-Doctoral