A new electrochemical platform based on low cost nanomaterials for sensitive detection of the amoxicillin antibiotic in different matrices

Author(s)

Wong, Ademar ^{[1, 2, 3]} ; Santos, Anderson M. ^[2] ; Cincotto, Fernando H. ^[4] ; Moraes, Fernando C. ^[2] ; Fatibello-Filho, Orlando ^[2] ; Sotomayor, Maria D. P. T. ^{[1, 3]}

Affiliation

^[1] State Univ Sao Paulo UNESP, Inst Chem, Dept Analyt Chem, BR-14801970 Araraquara, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Chem, POB 676, BR-13560970 Sao Carlos, SP - Brazil

^[3] Natl Inst Alternat Technol Detect, Toxicol Evaluat & Removal Micropollutants & Radio, BR-14801970 Araraquara, SP - Brazil

^[4] Univ Fed Rio de Janeiro, Inst Chem, BR-21941901 Rio De Janeiro, RJ - Brazil

• Document type: Journal article
• Source: Talanta; v. 206, JAN 1 2020.
• Web of Science Citations: 0

Abstract

A new electrochemical device based on a combination of nanomaterials such as Printex 6L Carbon and cadmium telluride quantum dots within a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate film was developed for sensitive determination of amoxicillin. The morphological, structural and electrochemical characteristics of the nanostructured material were evaluated using X-ray diffraction, confocal microscopy, transmission electron microscopy and voltammetric techniques. The synergy between these materials increased the electrochemical activity, the electron transfer rate and the electrode surface area, leading to a high magnitude of the anodic peak current for the determination of amoxicillin. The electrochemical determination of the antibiotic was carried out using square-wave voltammetry. Under the optimised experimental conditions, the proposed sensor showed high sensitivity, repeatability and stability to amoxicillin determination, with an analytical curve in the amoxicillin concentration range from 0.90 to 69 mu mol L-1, and a low detection limit of 50 nmol L-1. No significant interference in the electrochemical signal of amoxicillin was observed from potential biological interferences and drugs widely used, such as uric acid, paracetamol, urea, ascorbic acid and caffeine. It was demonstrated that without any sample pre-treatment and using a simple measurement device, the sensor could be an alternative method for not only the analysis of pharmaceutical products (commercial tablets) and clinical samples (urine), but also to examine food quality (milk samples). (AU)

• FAPESP's process: 16/16565-5 - Development of ultra-sensitive methods for RNA detection for the diagnosis of Head and Neck Cancer
• Grantee: Fernando Henrique Cincotto
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 14/50945-4 - INCT 2014: National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactivies
• Grantee: Maria Valnice Boldrin
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 17/10118-0 - Study and application of electrochemical technology for the analysis and degradation of endocrine interferents: materials, sensors, processes and scientific dissemination
• Grantee: Marcos Roberto de Vasconcelos Lanza
• Support type: Research Projects - Thematic Grants