Wearable electrochemical sensors for forensic and clinical applications

Author(s)

Ferreira, Patrick Cesar ^[1] ; Ataide, Vanessa Neiva ^[2] ; Silva Chagas, Cyro Lucas ^[2] ; Angnes, Lucio ^[2] ; Tomazelli Coltro, Wendell Karlos ^[3] ; Longo Cesar Paixao, Thiago Regis ^[2] ; de Araujo, William Reis ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Quim Analit, Inst Quim, BR-13083970 Campinas, SP - Brazil

^[2] Univ Sao Paulo, Dept Quim Fundamental, Inst Quim, BR-05508000 Sao Paulo - Brazil

^[3] Univ Fed Goias, Inst Quim, Campus Samambaia, BR-74690900 Goiania, Go - Brazil

• Document type: Review article
• Source: TRAC-TRENDS IN ANALYTICAL CHEMISTRY; v. 119, OCT 2019.
• Web of Science Citations: 1

Abstract

Electrochemical sensors are powerful analytical tools that, in the last few years, have attracted tremendous attention in coupling with wearable devices due to their incomparable properties, such as instrumental simplicity, low cost, flexibility, and miniaturization. These outstanding characteristics fit with the desired features for continuous on-body analyses. Wearable electrochemical sensors enable obtaining insights into individuals' health status through the noninvasive monitoring of clinically relevant biomarkers in different biofluids (saliva, tears, sweat, and interstitial fluids) without complex manipulation, sampling, and treatment steps. The electrochemical system can be fabricated in different substrates and transferred to the human body or coupled to common utensils to monitor (bio)chemical species or potentially hazardous compounds surrounding the users without disturbing their usual activities. In this work, we critically review the recent advances, the main technological and chemical challenges identified in wearable electrochemical sensors for forensic and clinical applications, high-lighting the remarkable trends, needs, and challenges for future studies. (C) 2019 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 18/14462-0 - Fabrication of electrochemical paper-based device aiming clinical and environmental applications
• Grantee: Vanessa Neiva de Ataide
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/10522-5 - Development of alternative methods for fabrication of electrochemical paper-based sensors
• Grantee: Thiago Regis Longo Cesar da Paixão
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/16477-9 - Fabrication of portable paper-based analytical devices with electrochemical and colorimetric detection system aiming at forensic, clinical, and environmental applications
• Grantee: William Reis de Araujo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/08782-1 - Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications
• Grantee: Mauro Bertotti
• Support Opportunities: Research Projects - Thematic Grants