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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Flexible platinum electrodes as electrochemical sensor and immunosensor for Parkinson's disease biomarkers

Full text
Author(s):
Mauruto de Oliveira, Gabriela C. [1] ; de Souza Carvalho, Jefferson Henrique [1] ; Brazaca, Lais Canniatti [2] ; Silva Vieira, Nirton Cristi [3] ; Janegitz, Bruno Campos [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Carlos, Dept Nat Sci Math & Educ, BR-13600970 Araras, SP - Brazil
[2] Univ Sao Paulo, Sao Carlos Inst Chem, Bioanal Microfluid & Separat Grp, BR-13566590 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Paulo, Inst Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: BIOSENSORS & BIOELECTRONICS; v. 152, MAR 15 2020.
Web of Science Citations: 0
Abstract

In this study, platinum electrodes were fabricated on the bio-based poly(ethylene terephthalate) (Bio-PET) substrates for the development of flexible electrochemical sensors for the detection of Parkinson's disease biomarkers. Dopamine was detected by voltammetric measurements, displaying a 3.5 x 10(-5) mol L-1 to 8.0 x 10(-4) mol L-1 linear range with a limit of detection of 5.1 x 10(-6) Mol( )L(-1). Parkinson's disease protein 7 (PARK7/DJ-1) was successfully detected by electrochemical impedance spectroscopy after electrode ftinctionalization with specific anti-PARK7/DJ-1 antibodies. In this case, analytical curves presented a linear behavior from 40 ng mL(-1) to 150 ng mL(-1) of PARK7/DJ-1 with a limit of detection of 7.5 ng mL(-1). Besides, the electrodes did not suffer any change in the electrochemical response after manual tests of mechanical tension. The proposed sensor and immunosensor were applied for the determination of Parkinson's disease biomarkers concentrations found in the human body, being adequate as an alternative method to diagnose this disease. (AU)

FAPESP's process: 17/17572-8 - Development of imunossensor and electrochemical sensor for detection of clinical character analyzes
Grantee:Gabriela Carolina Mauruto de Oliveira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 18/07508-3 - Exploring the electrical and optical properties of graphene derivatives for the detection of cyanotoxins
Grantee:Nirton Cristi Silva Vieira
Support Opportunities: Regular Research Grants
FAPESP's process: 19/04085-7 - Disposable and flexible sensors using polyethylene terephthalate (PET) and a new conductive ink for the detection of estriol in environmental and pharmaceutical samples
Grantee:Jefferson Henrique de Souza Carvalho
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use
Grantee:Osmar Malaspina
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 18/19750-3 - Exploring C4D detection for the development of innovative and low-cost microfluidic biosensors
Grantee:Laís Canniatti Brazaca
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/21898-6 - New conductive devices for application in electrochemical sensing and biosensing
Grantee:Bruno Campos Janegitz
Support Opportunities: Regular Research Grants