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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Microbial nanocellulose adherent to human skin used in electrochemical sensors to detect metal ions and biomarkers in sweat

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Author(s):
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Silva, Robson R. [1] ; Raymundo-Pereira, Paulo A. [1] ; Campos, Anderson M. [2] ; Wilson, Deivy [1] ; Otoni, Caio G. [3] ; Barud, Hernane S. [4] ; Costa, Carlos A. R. [5] ; Domeneguetti, Rafael R. [6] ; Balogh, Debora T. [1] ; Ribeiro, Sidney J. L. [6] ; Oliveira Jr, Osvaldo N.
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Sao Carlos Inst Chem, BR-13566590 Sao Carlos, SP - Brazil
[3] Univ Campinas UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil
[4] Univ Ctr Araraquara UNIARA, Biopolymers & Biomat Lab BIOPOLMAT, BR-14801340 Araraquara, SP - Brazil
[5] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Nanotechnol Natl Lab LNNano, BR-13083861 Campinas, SP - Brazil
[6] Sao Paulo State Univ UNESP, Dept Gen & Inorgan Chem, Rua Prof Francisco Degni 55, BR-4800060 Araraquara, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Talanta; v. 218, OCT 1 2020.
Web of Science Citations: 1
Abstract

The pursuit of biocompatible, breathable and skin-conformable wearable sensors has predominantly focused on synthetic stretchable hydrophobic polymers. Microbial nanocellulose (MNC) is an exceptional skin-substitute natural polymer routinely used for wound dressing and offers unprecedented potential as substrate for wearable sensors. A versatile strategy for engineering wearable sensing platforms is reported, with sensing units made of screen-printed carbon electrodes (SPCEs) on MNC. As-prepared SPCEs were used to detect the toxic metals cadmium (Cd2+) and lead (Pb2+) with limits of detection of 1.01 and 0.43 mu M, respectively, which are sufficient to detect these metal ions in human sweat and urine. SPCEs functionalized through anodic pre-treatments were used for detecting uric acid and 17 beta-estradiol in artificial sweat, with detection limits of 1.8 mu M and 0.58 mu M, respectively. The electrochemical treatment created oxygen groups on the carbon surfaces, thus improving wettability and hydrophilicity. MNC was herein exploited as an adhesive-free, yet highly skin-adherent platform for wearable sensing devices that also benefit from the semi-permeable, non-allergenic, and renewable features that make MNC unique within the pool of materials that have been used for such a purpose. Our findings have clear implications for the developments on greener and more biocompatible but still efficient substrates and may pave the route for combining immunosensing devices with drug delivery therapies. (AU)

FAPESP's process: 16/06612-6 - Printed and implantable biosensor made from biopolymers for long-term monitoring
Grantee:Robson Rosa da Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/01770-0 - Development of analytical tools based on electronic tongues for simultaneous detection of bacterial threats
Grantee:Deivy Wilson Masso
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/14262-7 - Nanostructured films from biologically-relevant materials
Grantee:Osvaldo Novais de Oliveira Junior
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/01919-6 - Design and fabrication of nanostructured flexible devices for biomarkers detection
Grantee:Paulo Augusto Raymundo Pereira
Support type: Scholarships in Brazil - Post-Doctorate