Determination of tadalafil in pharmaceutical samples by vertically oriented multi-walled carbon nanotube electrochemical sensing device

Author(s)

Zambianco, Naiara A. ^{[1, 2]} ; da Silva, Vinicius A. O. P. ^{[1, 2]} ; Orzari, Luiz O. ^{[3, 2]} ; Corat, Evaldo J. ^[4] ; Zanin, Hudson G. ^[5] ; Silva, Tiago A. ^[6] ; Buller, Gary A. ^[7] ; Keefe, Edmund M. ^[7] ; Banks, Craig E. ^[7] ; Janegitz, Bruno C. ^[2]

Affiliation

^[1] Univ Fed Sao Carlos, Ctr Exact Sci & Technol, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Nat Sci Math & Educ, BR-13600970 Araras, SP - Brazil

^[3] Univ Fed Sao Carlos, Dept Phys Chem & Math, BR-18052780 Sorocaba, SP - Brazil

^[4] Natl Inst Space Res, Ctr Special Technol, Associated Lab Sensors & Mat, BR-12227010 Sao Jose Dos Campos, SP - Brazil

^[5] Univ Estadual Campinas, Ctr Innovat New Energies, Sch Elect & Comp Engn, Adv Energy Storage Div, Carbon Sci Tech Labs & Mfg, BR-13083852 Campinas, SP - Brazil

^[6] Fed Ctr Technol Educ Minas Gerais, BR-35180008 Timoteo, MG - Brazil

^[7] Manchester Metropolitan Univ, Fac Sci & Engn, Chester St, Manchester M1 5GD, Lancs - England

• Document type: Journal article
• Source: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 877, NOV 15 2020.
• Web of Science Citations: 0

Abstract

In this work, an electrochemical sensor based on vertically oriented carbon nanotubes (voMWCNT), electrically wired via connection upon a copper plate, for the detection of tadalafil (TD) is reported. The voMWCNT is easily prepared via microwave plasma reactor with no additional post-treatment. The voMWCNT was characterized by scanning and transmission electron microscopy in addition to electrochemical characterization with cyclic voltammetry. Once TD is of easy access and used in the treatment of erectile dysfunction and related diseases, the quality control of this drug is of high importance. Using linear sweep voltammetry, the detection of TD was found to be possible from 0.85 to 8.9 mu mol L-1, with an R-2 of 0.992 with a limit of detection found to correspond to 78 mu mol L-1. The quantification of TD in different pharmaceutical drugs, as well as the device stability, indicates that the voMWCNT has potential for the routine sensing of TD. (C) 2020 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 16/12697-4 - Nanostructured sensors modified with graphene and tapioca for determination of phenolics compounds and nitrogenous bases
• Grantee: Luiz Otávio Orzari
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use
• Grantee: Osmar Malaspina
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants