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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Recent advances and possibilities for the use of plant phenolic compounds to manage ageing-related diseases

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Author(s):
Arruda, Henrique Silvano [1, 2] ; Neri-Numa, Iramaia Angelica [1] ; Kido, Larissa Akemi [2, 3] ; Marostica Junior, Mario Roberto [2] ; Pastore, Glaucia Maria [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Sch Food Engn, Dept Food Sci, Bioflavors & Bioact Cpds Lab, Monteiro Lobato St 80, BR-13083862 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, Nutr & Metab Lab, Monteiro Lobato St 80, BR-13083862 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Reprod Biol Lab, Bertrand Russel Ave S-N, BR-13083865 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Functional Foods; v. 75, DEC 2020.
Web of Science Citations: 0
Abstract

Ageing is an emerging global public health concern due to the increasing number of elderly people and ageing related degenerative disorders. Given the absence of effective treatments to manage ageing-related diseases, increasing efforts have been directed to find ways to reduce the risk of developing these disorders. Among them, plant phytochemicals, such as phenolic compounds, are considered potential anti-ageing agents due to their multifaceted biochemical actions. In this review, we focus on presenting the results of the last few years and pioneer researches mainly with animal models and human trials showing the key role of phenolic compounds as potential anti-ageing agents. Recent advances demonstrated that several phenolic compounds can reduce the risk and/or delay ageing-related disorders, including neurodegenerative diseases, metabolic syndromes, and cancers particularly by modulating signalling pathways involved in inflammation, oxidative damage, autophagy, and apoptosis. Therefore, plant phenolic compounds can be a complementary and alternative tool for managing ageing-related diseases. (AU)

FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
Grantee:Mário Roberto Maróstica Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
Grantee:Mário Roberto Maróstica Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 17/01573-5 - Effects of passion fruit bagasse extract (Passiflora edulis) in vitro and in vivo: chemopreventive and anti-inflammatory role of phenolic compounds in prostate cancer progression
Grantee:Larissa Akemi Kido de Barros
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
Grantee:Glaucia Maria Pastore
Support Opportunities: Research Projects - Thematic Grants