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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Long-term supplementation with phenolic compounds from jaboticaba (Plinia jaboticaba (Vell.) Berg) reduces adiposophaty and improves glucose, lipid, and energy metabolism

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Author(s):
Moura, Marcio H. C. [1] ; Donado-Pestana, Carlos M. [1, 2] ; Rodrigues, Larissa [1] ; Pessoa, Erika V. M. [1] ; Rossi e Silva, Rafaela [1] ; Festuccia, Willian T. [3] ; Genovese, Maria Ines [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Alimentos & Nutr Experimental, Av Prof Lineu Prestes, 580, Bloco 14, BR-05508900 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Food Res Ctr FoRC, Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Food Research International; v. 143, MAY 2021.
Web of Science Citations: 0
Abstract

Obesity is a critical public health problem worldwide that has been associated to non-communicable diseases (NCD), such as type 2 diabetes (T2DM), non-alcoholic fatty lipid diseases (NAFLD) and inflammatory diseases. Polyphenols from several food sources have been studied as one option against these health problems. Sabara jaboticaba (Plinia jaboticaba (Vell.) Berg) is a Brazilian berry rich in ellagic acid derivatives and anthocyanins. Here we investigated the effects of a phenolic-rich extract from Sabara jaboticaba (PEJ) in a diet-induced obesity animal model. PEJ at two doses, 50 mg gallic acid equivalent (GAE)/kg body weight (BW) and 100 mg GAE/kg BW, were administered by daily gavage to obese C57BL/6J mice for 14 weeks. PEJ prevented the excessive body weight and adiposity, adipocyte hypertrophy, inflammation, hyperglycemia, glucose intolerance, insulin resistance, hypercholesterolemia, and hepatic lipid accumulation, as well as increased energy expenditure. In conclusion, polyphenols from Sabara jaboticaba presented several powerful therapeutic properties relevant for fighting obesity and associated health problems. (AU)

FAPESP's process: 18/24477-4 - Modulation of intestinal microbiota and tissue proteomic analyses in obesity-induced inflammation and insulin resistance: Role of polyphenols from Brazilian native Myrtaceae fruits
Grantee:Maria Ines Genovese Rodriguez
Support Opportunities: Regular Research Grants
FAPESP's process: 20/16542-0 - Relationship between inflammation and primary metabolism in the postprandial period
Grantee:Carlos Mario Donado Pestana
Support Opportunities: Scholarships in Brazil - Post-Doctoral