| Full text | |
| Author(s): |
Fonseca, Elisa M.
[1]
;
Noronha-de-Souza, Carolina R.
[2]
;
Bicego, Kenia C.
[1]
;
Branco, Luiz G. S.
[3]
;
Gargaglioni, Luciane H.
[1]
Total Authors: 5
|
| Affiliation: | [1] Sao Paulo State Univ FCAV Jaboticabal, Dept Anim Morphol & Physiol, Jaboticabal, SP - Brazil
[2] Fed Univ Goias Jatai, Dept Morphophysiol, Jatai, Go - Brazil
[3] Univ Sao Paulo, Dent Sch Ribeirao Preto, Dept Basic & Oral Biol, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Respiratory Physiology & Neurobiology; v. 293, NOV 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Air-breathing vertebrates undergo respiratory adjustments when faced with disturbances in the gas composition of the environment. In mammals, the medullary raphe nuclei are involved in the neuronal pathway that mediates the ventilatory responses to hypoxia and hypercarbia. We investigate whether the serotoninergic neurons of the medullary raphe nuclei of toads (Rhinella diptycha) play a functional role in respiratory control during resting conditions (room air), hypercarbia (5% CO2), and hypoxia (5% O2). The raphe nuclei were located and identified based on the location of the serotoninergic neurons in the brainstem. We then lesioned the medullary raphe (raphe pallidus, obscurus and magnus) with anti-SERT-SAP and measured ventilation in both control and lesioned groups and we observed that serotonin (5-HT) specific chemical lesions of the medullary raphe caused reduced respiratory responses to both hypercarbia and hypoxia. In summary, we report that the serotoninergic neurons of the medullary raphe of the cururu toad Rhinella diptycha participate in the chemoreflex responses during hypercarbia and hypoxia, but not during resting conditions. This current evidence in anurans, together with the available data in mammals, brings insights to the evolution of brain sites, such as the medullary raphe, involved in the ventilatory chemoreflex in vertebrates. (AU) | |
| FAPESP's process: | 19/09469-8 - Effect of incubation temperature on chick metabolism, thermoregulation and chemosensitivity |
| Grantee: | Luciane Helena Gargaglioni Batalhão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/17681-9 - Pathophysiological changes during systemic inflammation |
| Grantee: | Luiz Guilherme de Siqueira Branco |
| Support Opportunities: | Research Projects - Thematic Grants |