| Full text | |
| Author(s): |
Aparecida Pereira, Ana Paula
[1, 2]
;
Figueiredo Angolini, Celio Fernando
[3]
;
de Souza-Sporkens, Jane Cristina
[4]
;
da Silva, Tomaz Antonio
[3]
;
Franco de Oliveira, Helena Coutinho
[4]
;
Pastore, Glaucia Maria
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Campinas UNICAMP, Fac Food Engn, Dept Food Sci, Rua Monteiro Lobato 80, BR-13083862 Campinas, SP - Brazil
[2] Univ Fed Mato Grosso, Fac Nutr, Dept Food & Nutr, Cuiaba, MG - Brazil
[3] Univ ABC UFABC, Ctr Nat & Human Sci, Santo Andre, SP - Brazil
[4] Univ Estadual Campinas, Biol Inst, Dept Struct & Funct Biol, Rua Monteiro Lobato 255, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Food Research International; v. 148, OCT 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Chronic high-glucose levels induce the generation of reactive oxygen species leading to mitochondrial dysfunction, which is one of the pathological triggers in the development of diabetes. This study investigated the alkaloid composition of two fruits of the genus Solanum, fruta-do-lobo (Solanum lycocarpum) and ju acute accent a-acu (So-lanum oocarpum), and their capacity to protect against oxidative damage and defective insulin secretion induced by chronic high-glucose levels. LC-MS and molecular network of fruit crude extracts reveals that ju acute accent a-acu and fruta-do-lobo contain kukoamines and glycoalkaloids, respectively. Two purification processes were used to enrich those alkaloids. Fruta-do-lobo extract rich in glycoalkaloids showed a strong cytotoxicity effect, however the ju acute accent a-acu enriched extract was able to protect mitochondrial functionality against glucotoxicity and stimulate insulin secretion even under conditions of hyperglycemia. These results are promising and suggest that ju acute accent a-acu is a potential source of bioactive compounds for adjuvant/co-adjuvant therapy for diabetes. (AU) | |
| FAPESP's process: | 19/08853-9 - Chemical Ecology of plant-microorganisms interactions studies for a sustainable agriculture |
| Grantee: | Célio Fernando Figueiredo Angolini |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/17728-8 - Mitochondrial function and dysfunction: implications for aging and associated diseases |
| Grantee: | Aníbal Eugênio Vercesi |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops |
| Grantee: | Glaucia Maria Pastore |
| Support Opportunities: | Research Projects - Thematic Grants |