Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases

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Fanalli, Simara Larissa ; Martins da Silva, Bruna Pereira ; Gomes, Julia Dezen ; Ciconello, Fernanda Nery ; de Almeida, Vivian Vezzoni ; Oliveira Freitas, Felipe Andre ; Monteiro Moreira, Gabriel Costa ; Silva-Vignato, Barbara ; Afonso, Juliana ; Reecy, James ; Koltes, James ; Koltes, Dawn ; Almeida Regitano, Luciana Correia ; de Carvalho Baileiro, Julio Cesar ; Freitas, Luciana ; Coutinho, Luiz Lehmann ; Fukumasu, Heidge ; de Alencar, Severino Matias ; Luchiari Filho, Albino ; Mello Cesar, Aline Silva

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 12, n. 1, p. 10-pg., 2022-06-20.

Abstract

Dietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. However, the consumers still associate dietary FA with fat deposition and increased occurrence of metabolic diseases such as obesity and atherosclerosis. Previous studies already demonstrated that some fatty acids are linked with inflammatory response, preventing metabolic diseases. To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. The key TF were identified by functional enrichment analysis from the list of differentially expressed genes identified in liver samples between 35 pigs fed with 1.5% or 3.0% soybean oil. The functional enrichment analysis detected TF linked to lipid homeostasis and inflammatory response, such as RXRA, EGFR, and SREBP2 precursor. These findings demonstrated that key TF related to lipid metabolism could be modulated by dietary inclusion of soybean oil. It could contribute to nutrigenomics research field that aims to elucidate dietary interventions in animal and human health, as well as to drive food technology and science. (AU)

• FAPESP's process: 17/25180-2 - Effect of dietary oleic acid on fatty acid composition and inflammatory response profile in different tissues of pigs
• Grantee: Aline Silva Mello Cesar
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 18/26797-6 - Effect of dietary oleic acid on fatty acid composition and inflammatory response profile in different tissues of pigs
• Grantee: Julia Pereira Martins da Silva
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 14/02493-7 - Mammary tumors of dogs and the cancer stem cell theory: a comparative and translational approach
• Grantee: Heidge Fukumasu
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 18/15653-3 - Effect of dietary oleic acid on fatty acid composition and inflammatory response profile in different tissues of pigs
• Grantee: Aline Silva Mello Cesar
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 18/26816-0 - Effect of dietary oleic acid on fatty acid composition and inflammatory response profile in different tissues of pigs
• Grantee: Julia Dezen Gomes
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 20/10042-6 - Lipid profile and transcriptome of the brain of swine feeded with different oil sources
• Grantee: Bruna Pereira Martins da Silva
• Support Opportunities: Scholarships in Brazil - Master