Jaboticaba (Plinia jaboticaba (Vell.) Berg) polyphenols alleviate skeletal muscle insulin resistance by modulating PI3K/Akt/GLUT-4 and AMPK signaling pathways in diet-induced obese mice

Author(s)

Pessoa, Erika V. M. ; Moura, Marcio H. C. ; Rodrigues, Larissa ; Rossi e Silva, Rafaela ; Castro, Erique ; Festuccia, William T. ; Donado-Pestana, Carlos M. ; Genovese, Maria Ines

• Document type: Journal article
• Source: FOOD PRODUCTION PROCESSING AND NUTRITION; v. 6, n. 1, p. 9-pg., 2024-08-04.

Abstract

Skeletal muscle responds for most of the insulin-stimulated glucose disposal at postprandial state, impacting glucose homeostasis. Polyphenols were shown to prevent obesity-associated glucose intolerance and peripheral insulin resistance in animal models, but the implication of skeletal muscle to these effects is unclear. We investigated the role of polyphenolic extracts from jaboticaba (Plinia jaboticaba (Vell.) Berg) (PEJ), a Brazilian native species, on skeletal muscle insulin resistance in diet-induced obese mice. PEJ administration was associated with an increase in skeletal muscle protein content of glucose transporter-4 (GLUT-4) and AMP-activated protein kinase (AMPK) phosphorylated at Thr172. PEJ also reduced skeletal muscle mRNA levels of inflammatory genes nuclear factor-kappa B (NF-kappa B), tumoral necrose factor-alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), and c-Jun N-terminal kinase (JNK). This study demonstrates that polyphenols from jaboticaba may be a valuable therapeutic agent in the management and prevention of obesity-associated metabolic disorders by reducing skeletal muscle obesity-associated insulin resistance and inflammation. (AU)

• FAPESP's process: 21/09237-0 - Postprandial metabolism and inflammation: the role of bile acids as signaling molecules
• Grantee: Larissa Rodrigues
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 20/16542-0 - Relationship between inflammation and primary metabolism in the postprandial period
• Grantee: Carlos Mario Donado Pestana
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/07914-8 - FoRC - Food Research Center
• Grantee: Bernadette Dora Gombossy de Melo Franco
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC