Multilayer microparticles for programmed sequential release of phenolic compounds from Eugenia stipitata: Stability and bioavailability

Author(s):Show less -

de Oliveira, Williara Queiroz ; Numa, Iramaia Angelica Neri ; Alvim, Izabela D. ; Azeredo, Henriette M. C. ; Santos, Leticia B. ; Borsoi, Felipe T. ; de Araujo, Fabio F. ; Sawaya, Alexandra C. H. F. ; do Nascimento, Gustavo C. ; Clerici, Maria Teresa P. S. ; do Sacramento, Celio K. ; Pastore, Glaucia Maria

• Document type: Journal article
• Source: Food Chemistry; v. 443, p. 12-pg., 2024-01-31.

Abstract

A co-delivery system based on multilayer microparticles was developed and characterized for the sequential release of phenolic compounds (PCs) using different encapsulation processes (spray drying: SD and drying-chilling spray: SDC) and wall materials to improve the stability and bioavailability of PCs. Samples were characterized in terms of process yield (PY%), phenolic retention efficiency (PRE%), chemical structure and crystallinity (NMR, FTIR, DXR), thermal stability (DSC and FT-IR), anti-radical capacity (ORAC and ABTS) and in vitro digestion. PRE% of samples by SD were higher (p < 0.05) than SDC due to the formation of PCs from CRF (car & aacute;-roxo flour). NMR, FTIR, DXR confirmed the presence of key components and interactions for the formation of the advanced co-delivery system. The SDC particles showed crystalline regions by XRD and were stable at similar to 47 degrees C. All samples showed good release of PC in the intestinal phase, and antiradical capacity that reached 23.66 mu mol TE g(-1). (AU)

• FAPESP's process: 20/08761-4 - Chemical characterization of bioactive compounds of non-conventional food plants (NCFP) for the development of products with functional appeal
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/15163-6 - Determination of chemical composition, bioaccessibility and evaluation of antidiabetic and prebiotic activities from Xique-Xique (Pilosocereus gounellei) and Mandacaru (Cereus jamacaru) fruits
• Grantee: Fábio Fernandes de Araújo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 22/04530-3 - Antidiabetic potential of xique-xique (Pilosocereus gounellei) and mandacaru (Cereus jamacaru) fruits after colonic fermentation
• Grantee: Fábio Fernandes de Araújo
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor