| Full text | |
| Author(s): Show less - |
de Souza, William M.
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Fumagalli, Marcilio J.
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de Lima, Shirlene T. S.
;
Parise, Pierina L.
;
Carvalho, Deyse C. M.
;
Hernandez, Cristian
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de Jesus, Ronaldo
;
Delafiori, Jeany
;
Candido, Darlan S.
;
Carregari, Victor C.
;
Muraro, Stefanie P.
;
Souza, Gabriela F.
;
Mello, Leda M. Simoes
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Claro, Ingra M.
;
Diaz, Yamilka
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Kato, Rodrigo B.
;
Trentin, Lucas N.
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Costa, Clauber H. S.
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Maximo, Ana Carolina B. M.
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Cavalcante, Karene F.
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Fiuza, Tayna S.
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Viana, Vania A. F.
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Melo, Maria Elisabeth L.
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Ferraz, Clarissa P. M.
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Silva, Debora B.
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Duarte, Larissa M. F.
;
Barbosa, Priscilla P.
;
Amorim, Mariene R.
;
Judice, Carla C.
;
Toledo-Teixeira, Daniel A.
;
Ramundo, Mariana S.
;
Aguilar, Patricia, V
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Araujo, Emerson L. L.
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Costa, Fabio T. M.
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Cerqueira-Silva, Thiago
;
Khouri, Ricardo
;
Boaventura, Viviane S.
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Figueiredo, Luiz Tadeu M.
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Fang, Rong
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Moreno, Brechla
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Lopez-Verges, Sandra
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Mello, Liana Perdigao
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Skaf, Munir S.
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Catharino, Rodrigo R.
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Granja, Fabiana
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Martins-de-Souza, Daniel
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Plante, Jessica A.
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Plante, Kenneth S.
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Sabino, Ester C.
;
Diamond, Michael S.
;
Eugenin, Eliseo
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Proenca-Modena, Jose Luiz
;
Faria, Nuno R.
;
Weaver, Scott C.
Total Authors: 54
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| Document type: | Journal article |
| Source: | CELL HOST & MICROBE; v. 32, n. 4, p. 26-pg., 2024-04-10. |
| Abstract | |
Chikungunya virus (CHIKV) is a mosquito -borne alphavirus that causes acute, subacute, and chronic human arthritogenic diseases and, in rare instances, can lead to neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomic, proteomic, and genomic analyses to investigate viral and host factors that contribute to chikungunya-associated (CHIK) death. Our results indicate that CHIK deaths are associated with multi -organ infection, central nervous system damage, and elevated serum levels of pro -inflammatory cytokines and chemokines compared with survivors. The histopathologic, metabolite, and proteomic signatures of CHIK deaths reveal hemodynamic disorders and dysregulated immune responses. The CHIKV East -Central -South -African lineage infecting our study population causes both fatal and survival cases. Additionally, CHIKV infection impairs the integrity of the blood -brain barrier, as evidenced by an increase in permeability and altered tight junction protein expression. Overall, our findings improve the understanding of CHIK pathophysiology and the causes of fatal infections. (AU) | |
| FAPESP's process: | 19/24251-9 - Multi-omic approaches for the study of Chikungunya disease |
| Grantee: | William Marciel de Souza |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 17/26908-0 - The role of IRF-5 in Oropouche virus pathogenesis and neurovirulence |
| Grantee: | Pierina Lorencini Parise |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 22/04420-3 - Role of IRF5 in Oropouche vírus pathogenesis and neurovirulence |
| Grantee: | Pierina Lorencini Parise |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |
| FAPESP's process: | 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) |
| Grantee: | Ester Cerdeira Sabino |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/27333-6 - Pathophysiology and diagnosis of arthritogenic alphavirus infections |
| Grantee: | Luiz Tadeu Moraes Figueiredo |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/05155-9 - The role of the glycoproteome and phosphoproteome during neuronal differentiation in schizophrenia |
| Grantee: | Victor Corasolla Carregari |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/17176-8 - Real-time, rapid detection and sequencing of arboviruses in Brazil: Zika, Dengue, Chikungunya and Yellow Fever |
| Grantee: | Ingra Morales Claro |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 17/25588-1 - From the basic understanding to clinical biomarkers to schizophrenia: a neuroproteomics-centered multidisciplinary study |
| Grantee: | Daniel Martins-de-Souza |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/00098-7 - Multi-User Equipment approved in grant 2017/25588-1: cromatógrafo Acquity UPLC I-Class |
| Grantee: | Daniel Martins-de-Souza |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 13/08293-7 - CCES - Center for Computational Engineering and Sciences |
| Grantee: | Munir Salomao Skaf |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 19/05718-3 - Determination of metabolic alterations and therapeutic potential of Zika Virus in cancer cells by mass spectrometry and artificial intelligence |
| Grantee: | Jeany Delafiori |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |