Simultaneous voltammetric determination of acetaminophen and caffeine at a graphite and polyurethane screen-printed composite electrode

Author(s)

Thalita R. Saciloto ^[1] ; Priscila Cervini ^[1] ; Éder T. G. Cavalheiro ^[3]

Affiliation

^[1] Univ Sao Paulo, Dept Quim & Fis Mol, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[2] Universidade de São Paulo. Instituto de Química de São Carlos. Departamento de Química e Física Molecular - Brasil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 24, n. 9, p. 1461-1468, 2013-09-00.

Abstract

A selective electrochemical method was developed for the individual or simultaneous determination of acetaminophen and caffeine in phosphate buffer pH 6.0 on graphite and polyurethane screen-printed composite electrode (EIGPU) using Differential Pulse Voltammetry (DPV). The oxidation peaks of acetaminophen and the caffeine appeared at 0.3 V and 1.3 V(vs. pseudo-Ag/AgCl), respectively, showing the possibility of simultaneous determination of both analytes, at the EIGPU, besides the individual determination. Analytical curves for the simultaneous determination showed a linear response for both compounds. The acetaminophen presented a linear region in the concentration range 1.00 - 40.0 µmol L-1 with detection limit of 0.84 µmol L-1, and the caffeine presented a linear region, in the concentration range 4.00 - 200 µmol L-1 with detection limit of 1.6 µmol L-1. The proposed method was applied in the simultaneous determination of acetaminophen and caffeine in three pharmaceutical formulations, with results similar to those obtained using a HPLC method, at 95% confidence level (Student t-Test). (AU)

• FAPESP's process: 10/05913-6 - Development and application of screen printed electrodes based on graphite and polyurethane composites
• Grantee: Thalita Rocha Saciloto
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 10/06485-8 - Development and application of screen printed and rod graphite and polyurethane based composite electrodes and molecularly imprinted polymers for analytical purposes
• Grantee: Priscila Cervini
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/11080-7 - Preparation and application of grafite-polimer based composite electrodes : modification with organofunctionalized silicas and molecurlay imprinted polymers
• Grantee: Éder Tadeu Gomes Cavalheiro
• Support Opportunities: Regular Research Grants