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Estudo do envolvimento do núcleo magno da rafe, do núcleo gigantocelular e núcleo pré-tectal anterior, e de receptores opiódes, kappa e delta serotoninérgicos 5HT2/1C, e noradrenérgicos alfa, beta, na analgesia pós-cital: um estudo neuroanatômico e neuropsicofisiológico em um modelo experimental de epilepsia

Processo: 02/01497-1
Linha de fomento:Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
Vigência (Início): 01 de fevereiro de 2003
Vigência (Término): 31 de dezembro de 2004
Área do conhecimento:Ciências Biológicas - Farmacologia - Neuropsicofarmacologia
Pesquisador responsável:Norberto Cysne Coimbra
Beneficiário:Daoud Hibrahim Elias Filho
Instituição-sede: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brasil
Vinculado ao auxílio:02/01496-5 - Estudo do envolvimento do núcleo magno da rafe, do núcleo gigantocelular e núcleo pré-tectal anterior, e de receptores opióides, mu, kappa e delta serotininérgicos 5-HT2A/2C e noradrenérgicos alfa e beta na analgesia pós-ictal: um estudo neuroanatômico e neuropsicofisiológico em um modelo experimental de epilepsia, AP.R
Assunto(s):Neurociências   Técnicas estereotáxicas   Microinjeções

Publicações científicas (36)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
MATIAS, JR., IVAIR; ELIAS, DAOUD HIBRAHIM; BERNARDINO GARCIA, CAMILA ARAUJO; SILVA, GUILHERME HENRIQUE; MEJIA, JORGE; CABRAL, FRANCISCO ROMERO; CAMARGO MIRANDA, ANA CLAUDIA; DA SILVA, SERGIO GOMES; LOPES, LUIZA DA SILVA; COIMBRA, NORBERTO CYSNE; MACHADO, HELIO RUBENS. A new model of experimental hemispherotomy in young adult Rattus norvegicus: a neural tract tracing and SPECT in vivo study. JOURNAL OF NEUROSURGERY, v. 130, n. 4, p. 1210-1223, APR 2019. Citações Web of Science: 1.
SOARES JR, RAIMUNDO DA SILVA; FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; COIMBRA, NORBERTO CYSNE. 5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus. Behavioural Brain Research, v. 357, n. SI, p. 71-81, JAN 14 2019. Citações Web of Science: 2.
DA SILVA, JULIANA ALMEIDA; ALMADA, RAFAEL CARVALHO; DE FIGUEIREDO, REBECA MACHADO; COIMBRA, NORBERTO CYSNE. Blockade of synaptic activity in the neostriatum and activation of striatal efferent pathways produce opposite effects on panic attack-like defensive behaviours evoked by GABAergic disinhibition in the deep layers of the superior colliculus. Physiology & Behavior, v. 196, p. 104-111, NOV 1 2018. Citações Web of Science: 1.
DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; FALCONI-SOBRINHO, LUIZ LUCIANO; BIAGIONI, AUDREY FRANCESCHI; ALMADA, RAFAEL CARVALHO; DOS ANJOS-GARCIA, TAYLLON; BAZAGLIA-DE-SOUSA, GUILHERME; KHAN, ASMAT ULLAH; COIMBRA, NORBERTO CYSNE. Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception. Physiology & Behavior, v. 194, p. 162-169, OCT 1 2018. Citações Web of Science: 1.
PASCHOALIN-MAURIN, TATIANA; DOS ANJOS-GARCIA, TAYLLON; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; CYSNE COIMBRA, JADE PISSAMIGLIO; LAURE, CARLOS JULIO; COIMBRA, NORBERTO CYSNE. The Rodent-versus-wild Snake Paradigm as a Model for Studying Anxiety- and Panic-like Behaviors: Face, Construct and Predictive Validities. Neuroscience, v. 369, p. 336-349, JAN 15 2018. Citações Web of Science: 8.
DA SILVA, JULIANA ALMEIDA; BIAGIONI, AUDREY FRANCESCHI; ALMADA, RAFAEL CARVALHO; DE FREITAS, RENATO LEONARDO; COIMBRA, NORBERTO CYSNE. Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus. Psychopharmacology, v. 234, n. 20, p. 3009-3025, OCT 2017. Citações Web of Science: 6.
COIMBRA, NORBERTO CYSNE; CALVO, FABRICIO; ALMADA, RAFAEL CARVALHO; FREITAS, RENATO LEONARDO; PASCHOALIN-MAURIN, TATIANA; DOS ANJOS-GARCIA, TAYLLON; ELIAS-FILHO, DAOUD HIBRAHIM; UBIALI, WALTER ADRIANO; LOBAO-SOARES, BRUNO; TRACEY, IRENE. OPIOID NEUROTRANSMISSION MODULATES DEFENSIVE BEHAVIOR AND FEAR-INDUCED ANTINOCICEPTION IN DANGEROUS ENVIRONMENTS. Neuroscience, v. 354, p. 178-195, JUN 23 2017. Citações Web of Science: 12.
NORBERTO C. COIMBRA; TATIANA PASCHOALIN-MAURIN; GABRIEL S. BASSI; ALEXANDRE KANASHIRO; AUDREY F. BIAGIONI; TATIANA T. FELIPPOTTI; DAOUD H. ELIAS-FILHO; JOYCE MENDES-GOMES; JADE P. CYSNE-COIMBRA; RAFAEL C. ALMADA; BRUNO LOBÃO-SOARES. Critical neuropsychobiological analysis of panic attack-and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus-and T-maze behavioral tests. Revista Brasileira de Psiquiatria, v. 39, n. 1, p. 72-83, Mar. 2017. Citações Web of Science: 9.
ULLAH, FARHAD; DOS ANJOS-GARCIA, TAYLLON; MENDES-GOMES, JOYCE; HIBRAHIM ELIAS-FILHO, DAOUD; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; KHAN, ASMAT ULLAH; DE OLIVEIRA, RICARDO; COIMBRA, NORBERTO CYSNE. Connexions between the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour. Behavioural Brain Research, v. 319, p. 135-147, FEB 15 2017. Citações Web of Science: 12.
DOS ANJOS-GARCIA, TAYLLON; ULLAH, FARHAD; FALCONI-SOBRINHO, LUIZ LUCIANO; COIMBRA, NORBERTO CYSNE. CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABA(A) receptor blockade in the dorsomedial division of the ventromedial hypothalamus. Neuropharmacology, v. 113, n. A, p. 156-166, FEB 2017. Citações Web of Science: 16.
FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; ELIAS-FILHO, DAOUD HIBRAHIM; COIMBRA, NORBERTO CYSNE. Unravelling cortico-hypothalamic pathways regulating unconditioned fear-induced antinociception and defensive behaviours. Neuropharmacology, v. 113, n. A, p. 367-385, FEB 2017. Citações Web of Science: 14.
DE OLIVEIRA, RICARDO; DE OLIVEIRA, RITHIELE CRISTINA; FALCONI-SOBRINHO, LUIZ LUCIANO; SOARES, JR., RAIMUNDO DA SILVA; COIMBRA, NORBERTO CYSNE. 5-Hydroxytryptamine(2A/2C) receptors of nucleus raphe magnus and gigantocellularis/paragigantocellularis pars alpha reticular nuclei modulate the unconditioned fear-induced antinociception evoked by electrical stimulation of deep layers of the superior colliculus and dorsal periaqueductal grey matter. Behavioural Brain Research, v. 316, p. 294-304, JAN 1 2017. Citações Web of Science: 9.
DE FREITAS, RENATO LEONARDO; MEDEIROS, PRISCILA; KHAN, ASMAT ULLAH; COIMBRA, NORBERTO CYSNE. mu(1)-Opioid receptors in the dorsomedial and ventrolateral columns of the periaqueductal grey matter are critical for the enhancement of post-ictal antinociception. Synapse, v. 70, n. 12, p. 519-530, DEC 2016. Citações Web of Science: 6.
MEDEIROS, P.; DE FREITAS, R. L.; SILVA, M. O.; COIMBRA, N. C.; MELO-THOMAS, L. CB1 CANNABINOID RECEPTOR-MEDIATED ANANDAMIDE SIGNALING MECHANISMS OF THE INFERIOR COLLICULUS MODULATE THE HALOPERIDOL-INDUCED CATALEPSY. Neuroscience, v. 337, p. 17-26, NOV 19 2016. Citações Web of Science: 3.
DE FREITAS, RENATO LEONARDO; MEDEIROS, PRISCILA; DA SILVA, JULIANA ALMEIDA; DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; ULLAH, FARHAD; KHAN, ASMAT ULLAH; COIMBRA, NORBERTO CYSNE. THE mu(1)-OPIOID RECEPTOR AND 5-HT2A- AND 5HT(2C)-SEROTONERGIC RECEPTORS OF THE LOCUS COERULEUS ARE CRITICAL IN ELABORATING HYPOALGESIA INDUCED BY TONIC AND TONIC-CLONIC SEIZURES. Neuroscience, v. 336, p. 133-145, NOV 12 2016. Citações Web of Science: 4.
BIAGIONI, AUDREY FRANCISCO; DOS ANJOS-GARCIA, TAYLLON; ULLAH, FARHAD; FISHER, ISAAC RENE; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; FELIPPOTTI, TATIANA TOCCHINI; COIMBRA, NORBERTO CYSNE. Neuroethological validation of an experimental apparatus to evaluate oriented and non-oriented escape behaviours: Comparison between the polygonal arena with a burrow and the circular enclosure of an open-field test. Behavioural Brain Research, v. 298, n. B, p. 65-77, FEB 1 2016. Citações Web of Science: 15.
DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; BIAGIONI, AUDREY FRANCISCO; FALCONI-SOBRINHO, LUIZ LUCIANO; COIMBRA, NORBERTO CYSNE. Dorsal raphe nucleus acetylcholine-mediated neurotransmission modulates post-ictal antinociception: The role of muscarinic and nicotinic cholinergic receptors. Brain Research, v. 1631, p. 80-91, JAN 15 2016. Citações Web of Science: 2.
ULLAH, FARHAD; DOS ANJOS-GARCIA, TAYLLON; DOS SANTOS, IEDA REGINA; BIAGIONI, AUDREY FRANCISCO; COIMBRA, NORBERTO CYSNE. Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of freezing or oriented and non-oriented escape emotional behaviors. Behavioural Brain Research, v. 293, p. 143-152, OCT 15 2015. Citações Web of Science: 26.
ALMADA, R. C.; RONCON, C. M.; ELIAS-FILHO, D. H.; COIMBRA, N. C. ENDOCANNABINOID SIGNALING MECHANISMS IN THE SUBSTANTIA NIGRA PARS RETICULATA MODULATE GABAergic NIGROTECTAL PATHWAYS IN MICE THREATENED BY URUTU-CRUZEIRO VENOMOUS PIT VIPER. Neuroscience, v. 303, p. 503-514, SEP 10 2015. Citações Web of Science: 19.
DA SILVA, JULIANA ALMEIDA; BIAGIONI, AUDREY FRANCISCO; ALMADA, RAFAEL CARVALHO; DE SOUZA CRIPPA, JOSE ALEXANDRE; CECILIO HALLAK, JAIME EDUARDO; ZUARDI, ANTONIO WALDO; COIMBRA, NORBERTO CYSNE. Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon. European Journal of Pharmacology, v. 758, p. 153-163, JUL 5 2015. Citações Web of Science: 12.
TEIXEIRA GONCALVES, THAIS CRISTINA; LONDE, ANNA KARLA; PIRES ALBANO, RAFAEL ISAAC; DE ARAUJO JUNIOR, ARTUR TEIXEIRA; AZEREDO, MARIANA DE AGUIAR; BIAGIONI, AUDREY FRANCISCO; FERREIRA VASCONCELLOS, THIAGO HENRIQUE; DOS REIS FERREIRA, CELIO MARCOS; TEIXEIRA, DULCINEA GONCALVES; DE SOUZA CRIPPA, JOSE ALEXANDRE; VIEIRA, DEBORA; COIMBRA, NORBERTO CYSNE. Cannabidiol and endogenous opioid peptide-mediated mechanisms modulate antinociception induced by transcutaneous electrostimulation of the peripheral nervous system. JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 347, n. 1-2, p. 82-89, DEC 15 2014. Citações Web of Science: 5.
DE FREITAS, RENATO LEONARDO; SALGADO-ROHNER, CARLOS JOSE; CECILIO HALLAK, JAIME EDUARDO; DE SOUZA CRIPPA, JOSE ALEXANDRE; COIMBRA, NORBERTO CYSNE. Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABA(A) receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid CB1 receptor. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, v. 16, n. 8, p. 1781-1798, SEP 2013. Citações Web of Science: 23.
BIAGIONI, AUDREY FRANCISCO; DE FREITAS, RENATO LEONARDO; DA SILVA, JULIANA ALMEIDA; DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; ALVES, VANI MARIA; COIMBRA, NORBERTO CYSNE. Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways. Neuropharmacology, v. 67, p. 379-394, APR 2013. Citações Web of Science: 29.
DA SILVA, JULIANA ALMEIDA; DE FREITAS, RENATO LEONARDO; DUTRA EICHENBERGER, GUSTAVO CAVALCANTI; PADOVAN, CLAUDIA MARIA; COIMBRA, NORBERTO CYSNE. Chemical neuroanatomical and psychopharmacological evidence that kappa receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour. European Journal of Pharmacology, v. 698, n. 1-3, p. 235-245, JAN 5 2013. Citações Web of Science: 13.
DE FREITAS, RENATO LEONARDO; LOPES KUEBLER, JOAO MARCUS; ELIAS-FILHO, DAOUD HIBRAIM; COIMBRA, NORBERTO CYSNE. Antinociception induced by acute oral administration of sweet substance in young and adult rodents: The role of endogenous opioid peptides chemical mediators and mu(1)-opioid receptors. Pharmacology Biochemistry and Behavior, v. 101, n. 2, p. 265-270, APR 2012. Citações Web of Science: 16.
FELIPPOTTI, TATIANA TOCCHINI; DE FREITAS, RENATO LEONARDO; COIMBRA, NORBERTO CYSNE. Endogenous opioid peptide-mediated neurotransmission in central and pericentral nuclei of the inferior colliculus recruits mu(1)-opioid receptor to modulate post-ictal antinociception. Neuropeptides, v. 46, n. 1, p. 39-47, FEB 2012. Citações Web of Science: 14.
URIBE-MARINO, ANDRES; FRANCISCO, AUDREY; CASTIBLANCO-URBINA, MARIA ANGELICA; TWARDOWSCHY, ANDRE; SALGADO-ROHNER, CARLOS JOSE; CRIPPA, JOSE ALEXANDRE S.; CECILIO HALLAK, JAIME EDUARDO; ZUARDI, ANTONIO WALDO; COIMBRA, NORBERTO CYSNE. Anti-Aversive Effects of Cannabidiol on Innate Fear-Induced Behaviors Evoked by an Ethological Model of Panic Attacks Based on a Prey vs the Wild Snake Epicrates cenchria crassus Confrontation Paradigm. NEUROPSYCHOPHARMACOLOGY, v. 37, n. 2, p. 412-421, JAN 2012. Citações Web of Science: 42.
FELIPPOTTI, TATIANA TOCCHINI; DO CARMO, DEVANEY RIBEIRO; PAIM, LEONARDO LATARO; STRADIOTTO, NELSON RAMOS; BICALHO, URQUISA DE OLIVEIRA; PARADA, CARLOS AMILCAR; GRILLO, RENATO; FRACETO, LEONARDO FERNANDES; COIMBRA, NORBERTO CYSNE. Effect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides mu(1) receptor-mediated post-ictal antinociception. Nanomedicine-Nanotechnology Biology and Medicine, v. 7, n. 6, p. 871-880, DEC 2011. Citações Web of Science: 13.
MIYASE, CÁTIA ISUMI; KISHI, RENATO; PAZ, DENISE AMORIM; COIMBRA, NORBERTO CYSNE; FREITAS, RENATO LEONARDO DE. Involvement of pre- and post-synaptic serotonergic receptors of dorsal raphe nucleus neural network in the control of the sweet-substance-induced analgesia in adult Rattus norvegicus (Rodentia, Muridae). Neuroscience Letters, v. 379, n. 3, p. 169-173, May 2005.
FREITAS, RENATO LEONARDO DE; OLIVEIRA, RITHIELE CRISTINA DE; CARVALHO, ANDRESSA DAIANE DE; FELIPPOTTI, TATIANA TOCCHINI; BASSI, GABRIEL SHIMIZU; ELIAS-FILHO, DAOUD HIBRAHIM; COIMBRA, NORBERTO CYSNE. Role of muscarinic and nicotinic cholinergic receptors in an experimental model of epilepsy-induced analgesia. Pharmacology Biochemistry and Behavior, v. 79, n. 2, p. 367-376, Oct. 2004.
GARGAGLIONI, LUCIANE H.; COIMBRA, NORBERTO C.; BRANCO, LUIZ G. S. The nucleus raphe magnus modulates hypoxia-induced hyperventilation but not anapyrexia in rats. Neuroscience Letters, v. 347, n. 2, p. 121-125, Aug. 2004.
BORELLI, KARINA GENARO; NOBRE, MANOEL JORGE; BRANDÃO, MARCUS LIRA; COIMBRA, NORBERTO CYSNE. Effects of acute and chronic fluoxetine and diazepam on freezing behavior induced by electrical stimulation of dorsolateral and lateral columns of the periaqueductal gray matter. Pharmacology Biochemistry and Behavior, v. 77, n. 3, p. 557-566, Mar. 2004.
OLIVEIRA, LUCIANA DE; CUNHA, ALEXANDRA OLIMPIO SIQUEIRA; MORTARI, MÁRCIA RENATA; PIZZO, ANDRÉA BALDOCCHI; MIRANDA, ANTONIO; COIMBRA, NORBERTO CYSNE; SANTOS, WAGNER FERREIRA DOS. Effects of microinjections of neurotoxin AvTx8, isolated from the social wasp Agelaia vicina (Hymenoptera, Vespidae) venom, on GABAergic nigrotectal pathways. Brain Research, v. 1031, n. 1, p. 74-81, Jan. 2004.
OSAKI, M. Y.; CASTELLAN-BALDAN, L.; CALVO, F.; CARVALHO, A. D.; FELIPPOTTI, T. T.; OLIVEIRA, R. DE; UBIALI, W. A.; PASCHOALIN-MAURIN, T.; ELIAS-FILHO, D. H.; MOTTA, V.; ET AL. Neuroanatomical and neuropharmacological study of opioid pathways in the mesencephalic tectum: effect of mu(1)- and kappa-opioid receptor blockade on escape behavior induced by electrical stimulation of the inferior colliculus. Brain Research, v. 992, n. 2, p. 179-192, Dec. 2003.

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