Brazilian high-risk cohort for psychiatric disorders: 10 years follow-up

• Grant number: 21/05332-8
• Support Opportunities: Research Projects - Thematic Grants
• Start date: February 01, 2022
• End date: January 31, 2027
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Rodrigo Affonseca Bressan
• Grantee: Rodrigo Affonseca Bressan
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Pesquisadores principais: João Ricardo Sato ; Síntia Iole Nogueira Belangero
• Associated researchers: André Zugman ; Arthur Caye ; Ary Gadelha de Alencar Araripe Neto ; Carolina Cappi ; Carolina Muniz Felix de Carvalho ; Douglas Teixeira Leffa ; Eurípedes Constantino Miguel Filho ; Giovanni Abrahão Salum Júnior ; Jair de Jesus Mari ; Luis Augusto Paim Rohde ; Marcelo Camargo Batistuzzo ; Marcelo Queiroz Hoexter ; Marcos Leite Santoro ; Mauricio Scopel Hoffmann ; Nicolas Andres Crossley Karmelic ; Pedro Mario Pan Neto ; Roseli Gedanke Shavitt ; Síntia Iole Nogueira Belangero ; Vanessa Kiyomi Ota Kuniyoshi
• Associated research grant(s): 24/02304-1 - Examining the genetic overlap between internalizing and externalizing behaviors, AP.R; 23/00437-1 - Multi-user equipment approved in grant 2021/05332-8: Biomek i5 Automated Workstation, AP.EMU
• Associated scholarship(s): 25/02111-1 - DEEP-MIND (Deep Learning for Mental Health): Application of Deep Learning in the Brazilian High-Risk Cohort for the Integration of Genomic and Clinical Data, BP.PD; 24/15037-1 - Characterization of LINE-1 genomic regions in subjects from a high-risk community cohort for psychiatric conditions, BP.DD; 23/02616-0 - Use of Graph convolutional neural networks in fMRI data for characterization of psychiatric disorders., BP.MS; 22/15880-5 - Impact of genetic variants on structural neuroimaging: a longitudinal approach in psychiatric disorders, BP.DD; 22/07782-3 - Assessment of child neurodevelopment through neuroimages and deep neural network models, BP.DD

Abstract

Psychiatric disorders are among the main causes of socio-occupational disability in western countries and their impact grows every year. Most of these psychiatric disorders begin in childhood or adolescence, with about one in ten children worldwide diagnosed with a psychiatric disorder. However, little investment in research is devoted to the study of mental disorders in this age group. Very little is known about the risk and protective factors in the trajectories related to the origin and course of these disorders. The investigation of these trajectories can bring important advances in the treatment and, mainly, in the prevention of these disorders. A total of 9,957 families from 57 schools in Porto Alegre and São Paulo were interviewed. Of these families, 2,511 participants were selected at the baseline (2010-2011), when information about them and their families was collected, especially parents and siblings. About 2,000 participants were reassessed three years later and 1,800 six years later. The present project plans to present the objectives, methods and justification for the reassessment of these participants in the 10-year follow-up. The main objective of this project is to seek environmental, genetic, neuropsychological and neuroimaging information from the aforementioned cohort in order to investigate the normal and abnormal trajectory of neurodevelopment, in addition to investigating risk and protective factors that may be related to mental health-related outcomes in childhood, adolescence and early adulthood. The aim of this project is to generate knowledge about neurobiological pathways of typical and atypical development and to identify and validate predictors capable of informing risk criteria to advance mental health prevention strategies. (AU)

Scientific publications

(18)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SATO, JOAO RICARDO; GIANLORENCO, ANNA CAROLYNA; FERNANDES, ELAYNE BORGES; DA ROCHA, THALITA FRIGO; MAKIYAMA, ANTONIO MASSATO; DIPIETRO, LAURA. An Experiment Using Functional Near-Infrared Spectroscopy and Robot-Assisted Multi-Joint Pointing Movements of the Lower Limb. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, v. N/A, n. 208, p. 19-pg., 2024-06-01. (18/09559-4, 21/05332-8, 18/04654-9, 18/21934-5, 23/02538-0)

FERNANDA ROHRSETZER; JOANA BISOL BALARDIN; FELIPE PICON; JOÃO RICARDO SATO; LUCAS BATTEL; ANNA VIDUANI; PEDRO HENRIQUE MANFRO; LEEHYUN YOON; BRANDON A. KOHRT; HELEN L. FISHER; et al. A magnetic resonance imaging-based morphometric and structural covariance network study of Brazilian adolescents stratified by depression risk. Revista Brasileira de Psiquiatria, v. 45, n. 4, p. 318-326, 2023-08-28. (18/21934-5, 21/05332-8, 18/04654-9)

PRISCILA BENITEZ; CAMILA DOMENICONI; AMANDA YUMI AMBRIOLA OKU; RAIMUNDO DA SILVA SOARES JUNIOR; FERNANDA YUMI RIBEIRO MORI; LINCOLN SASSAKI; THAINÁ LETÍCIA DOURADO MOURA; THARINY OLIVEIRA; LIZBETH CONTI DE CARVALHO OLIVEIRA; GIOVANA DA SILVA; et al. Análise da Viabilidade de Uso do FNIRS em Atividades Educacionais com Crianças e Jovens com Deficiência Intelectual e Autismo. Rev. bras. educ. espec., v. 29, 2023-07-31. (21/05332-8, 19/25795-2, 18/21934-5, 20/04777-3, 08/57705-8)

REBELLO, KEILA; MOURA, LUCIANA MONTEIRO; ARANTES BUENO, ANA PAULA; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; GADELHA, ARY; MIGUEL, EURIPEDES CONSTATINO; BRESSAN, RODRIGO AFFONSECA; ROHDE, LUIS AUGUSTO; SATO, JOAO RICARDO. Associations between Family Functioning and Maternal Behavior on Default Mode Network Connectivity in School-Age Children. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 19, n. 10, p. 10-pg., 2022-05-01. (21/05332-8, 18/04654-9, 14/50917-0, 16/19376-9, 18/21934-5)

SIMIS, MARCEL; MARQUES, LUCAS MURRINS; BARBOSA, SARA PINTO; SUGAWARA, ANDRE TADEU; SATO, JOAO RICARDO; PACHECO-BARRIOS, KEVIN; BATTISTELLA, LINAMARA RIZZO; FREGNI, FELIPE. Distinct patterns of metabolic motor cortex activity for phantom and residual limb pain in people with amputations: A functional near-infrared spectroscopy study. NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY, v. 54, n. 1, p. 8-pg., 2024-02-20. (20/08512-4, 17/12943-8, 21/05897-5, 21/05332-8, 18/04654-9, 18/21934-5, 23/02538-0)

KURTH, F.; SCHIJVEN, D.; VAN DEN HEUVEL, O. A.; HOOGMAN, M.; VAN ROOIJ, D.; STEIN, D. J.; BUITELAAR, J. K.; BOLTE, S.; AUZIAS, G.; KUSHKI, A.; et al. Large-scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents. Human Brain Mapping, v. 45, n. 11, p. 16-pg., 2024-08-01. (21/05332-8, 14/50917-0)

MENDES, SERGIO LEONARDO; PINAYA, WALTER HUGO LOPEZ; PAN, PEDRO MARIO; JACKOWSKI, ANDREA PAROLIN; BRESSAN, RODRIGO AFFONSECA; SATO, JOAO RICARDO. Generalizability of 3D CNN models for age estimation in diverse youth populations using structural MRI. SCIENTIFIC REPORTS, v. 13, n. 1, p. 12-pg., 2023-04-27. (18/04654-9, 22/07782-3, 18/21934-5, 21/05332-8)

AYAZ, HASAN; BAKER, WESLEY B.; BLANEY, GILES; BOAS, DAVID A.; BORTFELD, HEATHER; BRADY, KENNETH; BRAKE, JOSHUA; BRIGADOI, SABRINA; BUCKLEY, ERIN M.; CARP, STEFAN A.; et al. Optical imaging and spectroscopy for the study of the human brain: status report. NEUROPHOTONICS, v. 9, p. 65-pg., 2022-08-01. (18/04654-9, 19/21962-1, 16/22990-0, 13/07559-3, 21/05332-8, 18/21934-5)

SATO, JOAO RICARDO; BIAZOLI, CLAUDINEI EDUARDO; BUENO, ANA PAULA ARANTES; CAYE, ARTHUR; PAN, PEDRO MARIO; SANTORO, MARCOS; HONORATO-MAUER, JESSICA; SALUM, GIOVANNI ABRAHAO; HOEXTER, MARCELO QUEIROZ; BRESSAN, RODRIGO AFFONSECA; et al. Polygenic risk score for attention-deficit/hyperactivity disorder and brain functional networks segregation in a community-based sample. GENES BRAIN AND BEHAVIOR, v. N/A, p. 9-pg., 2023-02-21. (18/04654-9, 16/13737-0, 13/08531-5, 21/05332-8, 16/04983-7, 18/21934-5)

GRACCIELLE R. CUNHA; ARTHUR CAYE; PEDRO PAN; HELEN L. FISHER; RIVKA PEREIRA; CAROLINA ZIEBOLD; RODRIGO BRESSAN; EURÍPEDES CONSTANTINO MIGUEL; GIOVANNI A. SALUM; LUIS AUGUSTO ROHDE; et al. Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample. Revista Brasileira de Psiquiatria, v. 45, n. 3, p. 242-248, 2023-07-03. (21/05332-8, 14/50917-0)

HONORATO-MAUER, JESSICA; XAVIER, GABRIELA; OTA, VANESSA KIYOMI; CHEHIMI, SAMAR NASSER; MAFRA, FERNANDA; CUOCO, CASSIA; ITO, LUCAS TOSHIO; ORMOND, RAFAELLA; ASPRINO, PAULA FONTES; OLIVEIRA, ADRIELLE; et al. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. TRANSLATIONAL PSYCHIATRY, v. 13, n. 1, p. 9-pg., 2023-02-06. (17/25016-8, 17/05339-7, 21/09584-1, 08/57896-8, 20/02247-7, 14/50917-0, 21/05332-8, 16/19462-2)

DI SANTI, TALITA; NASCIMENTO, ARIANA GOMES; FUKUTI, PEDRO; MARCHISIO, VINNIE; DO AMARAL, GIAN CARLO ARAUJO; VAZ, CAMILLE FIGUEIREDO PETERNELLA; CARRIJO, LUIZ DAVID FINOTTI; DE OLIVEIRA, LILIAN CRISTIE; DA COSTA, LUIZ OCTAVIO; KONIECZNIAK, ELISANGELA MANCINI MARION; et al. Measuring Mental Health in 2 Brazilian University Centers: Protocol for a Cohort Survey. JMIR RESEARCH PROTOCOLS, v. 14, p. 10-pg., 2025-01-01. (21/05332-8, 21/12901-9)

KIM, BO-GYEOM; KIM, GAKYUNG; ABE, YOSHINARI; ALONSO, PINO; AMEIS, STEPHANIE; ANTICEVIC, ALAN; ARNOLD, PAUL D.; BALACHANDER, SRINIVAS; BANAJ, NERISA; BARGALLO, NURIA; et al. White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group. MOLECULAR PSYCHIATRY, v. N/A, p. 14-pg., 2024-02-07. (21/05332-8, 18/21934-5, 18/21934-5)

ECHEVARRIA, M. A. N.; BATISTUZZO, M. C.; SILVA, R. M. F.; BRUNONI, A. R.; SATO, J. R.; MIGUEL, E. C.; HOEXTER, M. Q.; SHAVITT, R. G.. Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder. Journal of Affective Disorders, v. 355, p. 9-pg., 2024-04-01. (19/06009-6, 21/05332-8, 14/50917-0, 18/04654-9, 18/21934-5, 19/27250-3, 12/20911-5)

DOS SANTOS, PEDRO MACHADO NERY; MENDES, SERGIO LEONARDO; BIAZOLI, CLAUDINEI; GADELHA, ARY; SALUM, GIOVANNI ABRAHAO; MIGUEL, EURIPEDES CONSTANTINO; ROHDE, LUIS AUGUSTO; SATO, JOAO RICARDO. Assessing atypical brain functional connectivity development: An approach based on generative adversarial networks. FRONTIERS IN NEUROSCIENCE, v. 16, p. 12-pg., 2023-01-09. (22/07782-3, 18/04654-9, 20/04119-6, 14/50917-0, 21/05332-8, 18/21934-5)

SOARES JR, RAIMUNDO DA SILVA; OKU, AMANDA YUMI AMBRIOLA; BARRETO, CANDIDA S. F.; SATO, JOAO RICARDO. Exploring neural efficiency in spatial cognition: A comparative study of 3D visual stimuli in virtual reality across STEM and non-STEM fields. Behavioural Brain Research, v. 477, p. 9-pg., 2024-10-19. (23/16997-6, 21/05332-8, 18/04654-9, 19/17907-5, 18/21934-5, 23/02538-0, 23/13418-5)

SATO, JOAO RICARDO; PEREIRA, TIAGO DUARTE; MARTINS, CLARICE MARIA DE LUCENA; BEZERRA, THAYNA ALVES; QUEIROZ, MARIA EDUARDA; COSTA, LARISSA PEREIRA; ANDRADE, SUELLEN MARINHO; BIAZOLI, CLAUDINEI EDUARDO. A Novel Exploratory Graph-Based Analytical Tool for Functional Near-Infrared Spectroscopy in Naturalistic Experiments: An Illustrative Application in Typically Developing Children. BRAIN SCIENCES, v. 13, n. 6, p. 9-pg., 2023-06-01. (18/04654-9, 19/27250-3, 18/21934-5, 21/05332-8)

SOARES, RAIMUNDO DA SILVA; PINHEIRO, ENEYSE DAYANE; OKU, AMANDA YUMI AMBRIOLA; RIZZO, MARILIA BISCAIA; VIEIRA, CAROLINNE DAS NEVES; SATO, JOAO RICARDO. Integrating Students' Real-Time Gaze in Teacher-Student Interactions: Case Studies on the Benefits and Challenges of Eye Tracking in Primary Education. APPLIED SCIENCES-BASEL, v. 14, n. 23, p. 17-pg., 2024-12-01. (23/18337-3, 23/12217-6, 21/05332-8, 23/02538-0)