EMU granted in process 2020/02207-5: high resolution mass spectrometer with electrospray ionizing source (ESI-QTOF)

• Grant number: 24/03447-0
• Support Opportunities: Multi-user Equipment Program
• Start date: August 01, 2024
• End date: July 31, 2031
• Field of knowledge: Health Sciences - Pharmacy - Pharmacognosy
• Principal Investigator: Norberto Peporine Lopes
• Grantee: Norberto Peporine Lopes
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 20/02207-5 - Inventorying secondary metabolism applying metabolomic strategies: contribution to the Brazilian biodiversity valuation, AP.BTA.TEM

Abstract

Plants and living organisms emit, detect and respond to chemical stimuli, thus creating an almost unlimited number of interactions through chemical signals. Most of these molecules are classified as secondary metabolites and are an important area of research in our country. Technological and intellectual advances in the last two decades have allowed the development of analyzes of natural products at various molecular levels, including molecular diversity and taxonomy, chemical ecology, understanding of circadian rhythms, among others. These advances have also deepened our understanding of nature to encompass interactions at various levels of organisms at different rates. Mass spectrometry instruments are important tools for investigating the incredibly diverse chemistry that is associated with these biological systems. Our ability to inventory this chemistry, using modern tools, has increased our understanding of the function of secondary metabolism. In this project, we intend to develop computer and spectrometry strategies in the universal analysis of small molecules, seeking to establish a comprehensive understanding of natural products in different biological models and seeking to add value to these substances through pharmacological evaluation. (AU)