In situ demineralization of enamel in response to a dentifrice with low fluoride content supplemented with phosphate

• Grant number: 07/03660-0
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2007
• End date: October 31, 2009
• Field of knowledge: Health Sciences - Dentistry - Pediatric Dentistry
• Principal Investigator: Alberto Carlos Botazzo Delbem
• Grantee: Alberto Carlos Botazzo Delbem
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The use of dentifrices with low fluoride (F) content have been a form to decrease the fluoride ingeston and, also, the dental fluorosis decrease. The aim of this study will be evaluated, in situ, the efficacy of dentifrices with low fluoride content supplemented with phosphate (P). 10 adult volunteers will use acrylic palatal appliances each containing four bovine enamel blocks. This study will be performed in 4 phases during 14 days and a interval of 7 days between the phases. The enamel blocks will be polish and selected through surface microhardness (SMH). The volunteers will drip on the enamel blocks a solution of 20% sucrose and perform the treatment with dentifrices containing 500µgf/g and 1% of a phosphate salt, placebo (without F e P) and Crest® (1100µgF/g). After each phase, the percentage change of SMH, mineral loss (ΔZ) will be calculated. The dental biofilm will be collected to perform the biochemical analysis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAKESHITA, ELIANA M.; DANELON, MARCELLE; CASTRO, LUCIENE P.; SASSAKI, KIKUE T.; DELBEM, ALBERTO C. B.. Effectiveness of a Toothpaste with Low Fluoride Content Combined with Trimetaphosphate on Dental Biofilm and Enamel Demineralization in situ. Caries Research, v. 49, n. 4, p. 394-400, 2015. (07/03660-0, 07/03254-2)

TAKESHITA, ELIANA M.; DANELON, MARCELLE; CASTRO, LUCIENE P.; CUNHA, ROBSON F.; DELBEM, ALBERTO C. B.. Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study. Caries Research, v. 50, n. 6, p. 571-578, 2016. (07/03660-0, 07/03254-2)