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Kinetic, Structural and functional characterization of LmjF24.0320. e LmjF29.1960 genes that code for fumarate hydratase in Leishmania major

Grant number: 08/08262-6
Support Opportunities:Regular Research Grants
Duration: November 01, 2008 - April 30, 2011
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Maria Cristina Nonato
Grantee:Maria Cristina Nonato
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FELICIANO, PATRICIA R.; DRENNAN, CATHERINE L.; CRISTINA NONATO, M.. Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold. Proceedings of the National Academy of Sciences of the United States of America, v. 113, n. 35, p. 9804-9809, . (09/10454-3, 11/19674-6, 08/08262-6)
FELICIANO, PATRICIA R.; DRENNAN, CATHERINE L.; NONATO, MARIA CRISTINA. Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate. ACS Chemical Biology, v. 14, n. 2, p. 266-275, . (08/08262-6, 14/22246-4, 13/14988-8)
CARDOSO, IARA AIME; LUIZ DE SOUZA, ALINE KUSUMOTA; BURGESS, ADAM MUSLEM GEORGE; CHALMERS, IAIN WYLLIE; HOFFMANN, KARL FRANCIS; NONATO, MARIA CRISTINA. Characterization of class II fumarase from Schistosoma mansoni provides the molecular basis for selective inhibition. International Journal of Biological Macromolecules, v. 175, p. 406-421, . (11/01495-8, 08/08262-6)
PEREIRA DE PADUA, RICARDO AUGUSTO; NONATO, MARIA CRISTINA. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of recombinant human fumarase. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 70, n. 1, p. 120-122, . (08/08262-6, 08/11644-8)
DE PADUA, RICARDO A. P.; KIA, ALI MARTIN; COSTA-FILHO, ANTONIO J.; WILKINSON, SHANE R.; NONATO, M. CRISTINA. Characterisation of the fumarate hydratase repertoire in Trypanosoma cruzi. International Journal of Biological Macromolecules, v. 102, p. 42-51, . (08/08262-6, 15/18390-5, 08/11644-8)
FELICIANO, PATRICIA R.; GUPTA, SHREEDHARA; DYSZY, FABIO; DIAS-BARUFFI, MARCELO; COSTA-FILHO, ANTONIO J.; MICHELS, PAUL A. M.; NONATO, M. CRISTINA. Fumarate hydratase isoforms of Leishmania major: Subcellular localization, structural and kinetic properties. International Journal of Biological Macromolecules, v. 51, n. 1-2, p. 25-31, . (08/08262-6, 06/05538-5, 09/10454-3, 09/15810-2)

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