Antonio Prudente Cancer Research Center

• Grant number: 98/14335-2
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• Start date: October 01, 2000
• End date: December 31, 2012
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Fernando Augusto Soares
• Grantee: Fernando Augusto Soares
• Host Institution: Hospital A C Camargo. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
• Pesquisadores principais:( Últimos ): Beatriz de Camargo ; Daniel Deheinzelin ; Luiz Paulo Kowalski ; Silvia Regina Rogatto
• Pesquisadores principais:( Antigos ): Andrew John George Simpson ; Luisa Lina Villa ; Luiz Fernando Lima Reis ; Ricardo Renzo Brentani ; Sergio Danilo Junho Pena
• Associated scholarship(s): 07/50609-0 - Validation of molecular classifiers in head and neck., BP.PD

Abstract

a) Description of the Center and its characteristic features. The Center consists of a vigorous and internationally respected research institute working in close collaboration with Brazil's foremost cancer hospital. Both institutions are private not for profit organizations which combine the flexibility and agility of the private sector together with a philanthropic mission to serve society. The two institutions, the Hospital do Cancer-AC Camargo (HCACC) and the Ludwig Institute for Cancer Research (LICR) enjoy an almost seamless integration due to the presence of a common director, the physical presence of the Institute within the has premises, the vigorous clinical research program that utilizes the molecular and bioinformatics infrastructure of the Institute, the molecular studies of the instill based heavily on the use of a recently implanted tumor bank as a collaborative effort between hospital and Institute staff, the common post graduate course in oncology and lastly their active participation in the design and execution of clinical diagnostic tests and genetic counseling. The mission of the Center is to improve Cancer Care through the pursuit of excellence in research and clinical practice. It is conceived that the discipline of a research environment is conduce to the attainment of high level, standardized clinical protocols and that the research itself, to be most effective, is oriented in its broadest terms by the limitation and needs highlighted by the application of state of the art clinical care. The HCACC was founded in 1934, in Sao Paulo, Brazil. This Institution is run by the Fundação Antonio Prudente of which Ricardo Brentani has been the President since 1990. Besides cancer care, the HCACC is committed with educational all research activities. The LICR currently consists of eleven branches. They are situated either within hospitals or are university departments with the aim of fostering clinically orientated research in the area of human cancer. The last year has seen a significant new investment on the part of the Institute in the area of genomics,and molecular genetics by the Sao Paulo branch in collaboration with the Office for Information Technology in Lausanne Switzerland. The Sao Paulo branch was founded in 1983 and has been under the directorship of Ricardo Brentani since its inauguration; b) definition of research focus and of its multidisciplinary connections. The research focus of the Center is the molecular dissection of the process of malignant transformation and the early clinical application of the acquired knowledge to provide optimized and individualized health care. Our vision of cancer is that of a somatic genetic disease that results from the inexorable acquisition of genetic defects during the natural human life span. Each tumor, a clone expansion from a cell that contains the correct permutation of mutation: ontogenesis and tumor suppressor genes, is distinct and to be fully understood (and optimally managed) would require a complete and detailed genome analysis: is possible to imagine a future technological scenario which would permit the early detection of tumors (or indeed the identification of still normal tissues at high risk of containing incipient tumors) and the rapid and minimally invasive analysis of the molecular phenotype of the tumor based on its gene expression profile leading to the selection of the best possible combination of available therapies to remove the tumor or delay its growth. To achieve this goal we need to first catalogue the complete protein coding content of the human genome, to define patterns of gene expression in healthy tissues, to identify the patters of mutation that result in cellular transformation, define the altered patters of gene expression that directly result from the mutational load and interpret these events in the of the biological and clinical behavior of individual tumors. This Center intends to provide a local focus for high quality, clinically based biotechnological project that will contribute to the international effort aimed at improving the diagnosis and treatment of human malignancies. Our goals will only be met by the continued pursuit of excellence across a broad range of clinical and scientific disciplines. First and foremost, our proposal is only viable in an environment of health care excellence. The perception of the needs and possible applications of biomolecular assays can only be made where state of the art clinical care is practiced in the diagnostic, surgical and therapeutic arenas. To complement this environment, access to and execution of the most powerful of the new era of biotechnological innovations is required. This involves gene identification, mutation detection and polymorphism determination together with powerful bioinformatics capacity for the compilation and annotation of human genome structure and highly parallel analysis of gene expression. This juxtaposition is provided by the unique combination of the presence of an internationally competitive institute for cancer research, the Ludwig Institute, within Brazil's foremost dedicated cane hospital; c) description of planned technology transfer and educational activities and of their relationship to the research focus. The organizational concept of the Hospital and the strategy of the LICR together provides a perfect environment for technology transfer and the nurturing of small business initiatives. The preferred means of further development of patented procedures and reagents is collaboration with local commercial laboratories and industries. This insures the possibility of immediate application within the local community as well as contributing to wealth creation and development of the local biotechnology community. In addition, the individual researchers contracted by the Institute are encouraged to play interactive roles with health care and commercial activities by means consultant ships and membership of scientific boards of biotechnology and clinical companies. The structure of the hospital is also conducive to the vigorous development of individual initiatives since all the clinical departments take the form of small businesses run and administered by the clinical staff themselves' renewable contracts, remunerated on the basis of performance and results, with the Fundação for the execution of defined clinically duties. The enormous benefit of this system is that it continually promotes the pursuit of efficiency and excellence and permits total flexibility in the hiring and continuation of only the best available physicians. The educational activities of the Center focus on post graduate training. This takes the form of both a well established program of clinic residency and post-graduate course in oncology; d) brief justification for the creation of a research center. The logical progression of the convergent course of two institutions over recent years would now be the establishment of a unified research center involving both entities. The dynamism, flexibility, administrative structure, clinical prowess, research excellence and multidisciplinary nature of such an amalgamation would ensure both a self sufficient center excellence and a focal point for large scale collaborative projects in the clinical and research fields. In practice the majority of both research and educational actives are already joint ventures between the professionals’ active in both institutions, a collaborative ideal achieved in great part by the common leadership which presently exists and which deserves to be consolidated in the form of a single research center. We believe that the future of health care and biomedical research in the local environment is intimately dependent on the existence of chosen institutions with access to the latest biotechnological innovations, professional excellence, administrative agility and a proven record of innovation, leadership and dissemination. The proposed center fulfills all of these criteria is thus a candidate for becoming a cornerstone in the fundamental changes in research structure and achievement that will be required over the coming decal order for local research to remain competitive in the international forum; e) description of facilities offered as counterpart by the participating Institution: The hospital has more than 200 beds available for cancer patients and all necessary diagnostic and support facilities associated with a major cancer treatment Center. The Hospital archives contain more than 300.000 medical reports with 90% five year follow up, histological slides and paraffin blocks from all register patients, a tumor bank for fresh tissues. The Ludwig Institute consists of 2.000 m2 of research and administrative space which supports four research groups working in laboratories with an infrastructure for basic molecular biology techniques, a sequencing facility, an animal facility and a bioinformatics service. As facilities, both the HCACC and the LICR, have libraries and auditoriums for small seminars as well as major symposia. The Center, in the context of the pre funding application, will be administered by the full time team at the LICR which consists of professionals in the areas of finance, personnel, importation and purchasing as well as maintenance. (AU)

Scientific publications

(39)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VICTOR PIANA DE ANDRADE; ISABELA WERNECK DA CUNHA; EDAISE MARIA DA SILVA; FERNANDA AYALA; YUKIE SATO; SEVERINO DA SILVA FERREIRA; CARLOS FERREIRA NASCIMENTO; FERNANDO AUGUSTO SOARES. O arranjo em matriz de amostras teciduais (tissue microarray): larga escala e baixo custo ao alcance do patologista. Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 43, n. 1, p. 55-60, 2007-02-00. (98/14335-2)

MASCHIETTO, MARIANA; PICCOLI, FABIO S.; COSTA, CECILIA M. L.; CAMARGO, LUIZ P.; NEVES, JOSE I.; GRUNDY, PAUL E.; BRENTANI, HELENA; SOARES, FERNANDO A.; DE CAMARGO, BEATRIZ; CARRARO, DIRCE M.. Gene expression analysis of blastemal component reveals genes associated with relapse mechanism in Wilms tumour. EUROPEAN JOURNAL OF CANCER, v. 47, n. 18, p. 2715-2722, DEC 2011. (98/14335-2, 06/00054-0)

CAVICCHIOLI BUIM, MARCILEI ELIZA; GURGEL, CLARISSA ARAUJO S.; GONCALVES RAMOS, EDUARDO ANTONIO; LOURENCO, SILVIA VANESSA; SOARES, FERNANDO AUGUSTO. Activation of sonic hedgehog signaling in oral squamous cell carcinomas: a preliminary study. HUMAN PATHOLOGY, v. 42, n. 10, p. 1484-1490, OCT 2011. (98/14335-2, 07/50609-0)

CARRARO, DIRCE MARIA; FERREIRA, ELISA NAPOLITANO; MOLINA, GUSTAVO DE CAMPOS; PUGA, RENATO DAVID; ABRANTES, EDUARDO FERNANDES; TRAPE, ADRIANA PRISCILA; EKHARDT, BEDRICH L.; NUNES, DIANA NORONHA; BRENTANI, MARIA MITZI; ARAP, WADIH; et al. Poly (A)(+) Transcriptome Assessment of ERBB2-Induced Alterations in Breast Cell Lines. PLoS One, v. 6, n. 6, JUN 22 2011. (98/14335-2)

CARVALHO‚ A.L.; IKEDA‚ M.K.; MAGRIN‚ J.; KOWALSKI‚ L.P.. Trends of oral and oropharyngeal cancer survival over five decades in 3267 patients treated in a single institution. Oral Oncology, v. 40, n. 1, p. 71-76, 2004. (98/14335-2)

PINHEIRO‚ N.A.; CABALLERO‚ O.L.; SOARES‚ F.; REIS‚ L.F.L.; SIMPSON‚ A.J.G.. Significant overexpression of oligophrenin-1 in colorectal tumors detected by cDNA microarray analysis. Cancer Letters, v. 172, n. 1, p. 67-73, 2001. (98/14335-2)

CARRARO‚ D.M.; FERREIRA‚ E.N.; DE CAMPOS MOLINA‚ G.; PUGA‚ R.D.; ABRANTES‚ E.F.; TRAPÉ‚ A.P.; EKHARDT‚ B.L.; NUNES‚ D.N.; BRENTANI‚ M.M.; ARAP‚ W.; et al. Poly (A)+ Transcriptome Assessment of ERBB2-Induced Alterations in Breast Cell Lines. PLoS One, v. 6, n. 6, p. e21022, 2011. (98/14335-2)

SILVEIRA, SARA MARTORELI; RIOS VILLACIS, ROLANDO ANDRE; MARCHI, FABIO ALBUQUERQUE; BARROS FILHO, MATEUS DE CAMARGO; DRIGO, SANDRA APARECIDA; NETO, CRISTOVAM SCAPULATEMPO; LOPES, ADEMAR; DA CUNHA, ISABELA WERNECK; ROGATTO, SILVIA REGINA. Genomic Signatures Predict Poor Outcome in Undifferentiated Pleomorphic Sarcomas and Leiomyosarcomas. PLoS One, v. 8, n. 6, JUN 25 2013. (98/14335-2)

NISHIMOTO, INES NOBUKO; PINHEIRO, NIDIA ALICE; ROGATTO, SILVIA REGINA; CARVALHO, ANDRÉ LOPES; SIMPSON, ANDREW J.; CABALLERO, OTÁVIA LUISA; KOWALSKI, LUIZ PAULO. Cyclin D1 gene polymorphism as a risk factor for squamous cell carcinoma of the upper aerodigestive system in non-alcoholics. Oral Oncology, v. 40, n. 6, p. 604-610, July 2004. (98/14335-2)

STOLF, BEATRIZ S.; ABREU, CINTIA M.; MAHLER-ARAÚJO, MARIA B.; DELLAMANO, MÁRCIA; MARTINS, WALESKA K.; CARVALHO, MARCOS BRASILINO DE; CURADO, MARIA P.; DÍAZ, JUAN P.; FABRI, ARTUR; BRENTANI, HELENA; et al. Expression profile of malignant and non-malignant diseases of the thyroid gland reveals altered expression of a common set of genes in goiter and papillary carcinomas. Cancer Letters, v. 227, n. 1, p. 59-73, Sept. 2005. (98/14335-2)

SILVA, A. P. M.; CHEN, J.; CARRARO, D. M.; WANG, S. M.; CAMARGO, A. A.. Generation of longer 3'cDNA fragments from massively parallel signature sequencing tags. Nucleic Acids Research, v. 32, n. 12, p. e94-e97, jul. 2004. (98/14335-2)

COUTINHO-CAMILLO, CLAUDIA MALHEIROS; LOURENCO, SILVIA VANESSA; NISHIMOTO, INES NOBUKO; KOWALSKI, LUIZ PAULO; SOARES, FERNANDO AUGUSTO. Expression of Bcl-2 family proteins and association with clinicopathological characteristics of oral squamous cell carcinoma. Histopathology, v. 57, n. 2, p. 304-316, AUG 2010. (98/14335-2)

COUTINHO-CAMILLO, CLAUDIA MALHEIROS; LOURENCO, SILVIA VANESSA; NISHIMOTO, INES NOBUKO; KOWALSKI, LUIZ PAULO; SOARES, FERNANDO AUGUSTO. Nucleophosmin, p53, and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray. HUMAN PATHOLOGY, v. 41, n. 8, p. 1079-1086, AUG 2010. (98/14335-2)

LOURENCO, SILVIA V.; COUTINHO-CAMILLO, CLAUDIA M.; BUIM, MARCILEI E. C.; PEREIRA, CLAUDIA M.; CARVALHO, ANDRE L.; KOWALSKI, LUIZ P.; SOARES, FERNANDO A.. Oral squamous cell carcinoma: status of tight junction claudins in the different histopathological patterns and relationship with clinical parameters. A tissue-microarray-based study of 136 cases. Journal of Clinical Pathology, v. 63, n. 7, p. 609-614, JUL 2010. (98/14335-2)

DA SILVA, EDAISE M.; ACHATZ, MARIA ISABEL W.; MARTEL-PLANCHE, GHYSLAINE; MONTAGNINI, ANDRE L.; OLIVIER, MAGALI; PROLLA, PATRICIA A.; HAINAUT, PIERRE; SOARES, FERNANDO A.. TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child - evidence for chimerism involving a common mutant founder haplotype: case report. BMC CANCER, v. 11, OCT 17 2011. (98/14335-2)

CUNHA‚ I.W.; LOPES‚ A.; FALZONI‚ R.; SOARES‚ F.A.. Sarcomas often express constitutive nitric oxide synthases (NOS) but infrequently inducible NOS. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v. 14, n. 4, p. 404-410, 2006. (98/14335-2)

LOURENÇO‚ S.V.; COUTINHO-CAMILLO‚ C.M.; BUIM‚ M.E.C.; DE CARVALHO‚ A.C.; LESSA‚ R.C.; PEREIRA‚ C.M.; VETTORE‚ A.L.; CARVALHO‚ A.L.; FREGNANI‚ J.H.; KOWALSKI‚ L.P.; et al. Claudin-7 down-regulation is an important feature in oral squamous cell carcinoma. Histopathology, v. 57, n. 5, p. 689-698, 2010. (98/14335-2)

YUKIE SATO; CARLOS FERREIRA NASCIMENTO; SEVERINO DA SILVA FERREIRA; JOSÉ HUMBERTO T. G. FREGNANI; FERNANDO AUGUSTO SOARES. Análise da expressão imuno-histoquímica de c-erbB-2 e EGFR em carcinoma epidermóide de esôfago. Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 43, n. 4, p. 275-283, 2007-08-00. (98/14335-2)

COUTINHO-CAMILLO, CLAUDIA MALHEIROS; LOURENCO, SILVIA VANESSA; LIMA, LEANDRO DE ARAUJO; KOWALSKI, LUIZ PAULO; SOARES, FERNANDO AUGUSTO. Expression of apoptosis-regulating miRNAs and target mRNAs in oral squamous cell carcinoma. CANCER GENETICS, v. 208, n. 7-8, p. 382-389, JUL-AUG 2015. (98/14335-2)

CASTRO, NADIA P.; OSORIO, CYNTHIA A. B. T.; TORRES, CESAR; BASTOS, ELEN P.; MOURAO-NETO, MARIO; SOARES, FERNANDO A.; BRENTANI, HELENA P.; CARRARO, DIRCE M.. Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma. BREAST CANCER RESEARCH, v. 10, n. 5, p. 14-pg., 2008-01-01. (98/14335-2)

BEGNAMI, MARIA D.; FREGNANI, JOSE HUMBERTO T. G.; BRENTANI, HELENA; TORRES, CESAR; COSTA, JR., WILSON LUIZ; MONTAGNINI, ANDRE; NONOGAKI, SUELY; SOARES, FERNANDO A.. Identification of protein expression signatures in gastric carcinomas using clustering analysis. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v. 27, n. 2, p. 378-384, FEB 2012. (98/14335-2)

MEIRELES, SIBELE I.; ESTEVES, GUSTAVO H.; HIRATA, JR., ROBERTO; PERI, SURAJ; DEVARAJAN, KARTHIK; SLIFKER, MICHAEL; MOSIER, STACY L.; PENG, JING; VADHANAM, MANICKA V.; HURST, HARRELL E.; et al. Early Changes in Gene Expression Induced by Tobacco Smoke: Evidence for the Importance of Estrogen within Lung Tissue. Cancer Prevention Research, v. 3, n. 6, p. 707-717, JUN 2010. (98/14335-2, 99/11962-9, 99/07390-0)

TERMINI, LARA; BOCCARDO, ENRIQUE; ESTEVES, GUSTAVO H.; HIRATA, JR., ROBERTO; MARTINS, WALESKA K.; COLO, ANNA ESTELA L.; NEVES, E. JORDAO; VILLA, LUISA LINA; REIS, LUIZ F. L.. Characterization of global transcription profile of normal and HPV-immortalized keratinocytes and their response to TNF treatment. BMC MEDICAL GENOMICS, v. 1, JUN 27 2008. (98/14335-2)

COUTINHO-CAMILLO, CLAUDIA MALHEIROS; LOURENCO, SILVIA VANESSA; NONOGAKI, SUELY; VARTANIAN, JOSE GUILHERME; NAGAI, MARIA APARECIDA; KOWALSKI, LUIZ PAULO; SOARES, FERNANDO AUGUSTO. Expression of PAR-4 and PHLDA1 is prognostic for overall and disease-free survival in oral squamous cell carcinomas. Virchows Archiv, v. 463, n. 1, p. 31-39, JUL 2013. (98/14335-2, 08/57887-9)

COLO, ANNA E. L.; SIMOES, ANA C. Q.; CARVALHO, ANDRE L.; MELO, CAMILA M.; FAHHAM, LUCAS; KOWALSKI, LUIZ P.; SOARES, FERNANDO A.; NEVES, EDUARDO J.; REIS, LUIZ F. L.; CARVALHO, ALEX F.. Functional microarray analysis suggests repressed cell-cell signaling and cell survival-related modules inhibit progression of head and neck squamous cell carcinoma. BMC MEDICAL GENOMICS, v. 4, APR 13 2011. (98/14335-2)

COUTINHO-CAMILLO, CLAUDIA MALHEIROS; LOURENCO, SILVIA VANESSA; NISHIMOTO, INES NOBUKO; KOWALSKI, LUIZ PAULO; SOARES, FERNANDO AUGUSTO. CASPASE EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v. 33, n. 8, p. 1191-1198, AUG 2011. (98/14335-2)

COUTINHO-CAMILLO, CLAUDIA MALHEIROS; LOURENCO, SILVIA VANESSA; DA FONSECA, FRANCISCO PAULO; SOARES, FERNANDO AUGUSTO. Claudin expression is dysregulated in prostate adenocarcinomas but does not correlate with main clinicopathological parameters. PATHOLOGY, v. 43, n. 2, p. 143-148, FEB 2011. (98/14335-2)

CUNHA, ISABELA WERNECK; CARVALHO, KATIA CANDIDO; MARTINS, WALESKA KELLER; MARQUES, SARAH MARTINS; MUTO, NAIR HIDEKO; FALZONI, ROBERTO; ROCHA, RAFAEL MALAGOLI; AGUIAR, JR., SAMUEL; SIMOES, ANA C. Q.; FAHHAM, LUCAS; et al. Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors. TRANSLATIONAL ONCOLOGY, v. 3, n. 1, p. 23-U39, FEB 2010. (98/14335-2)

MASCHIETTO, MARIANA; DE CAMARGO, BEATRIZ; BRENTANI, HELENA; GRUNDY, PAUL; SREDNI, SIMONE T.; TORRES, CESAR; MOTA, LOUISE D.; CUNHA, ISABELA W.; PATRAO, DIOGO F. C.; COSTA, CECILIA M. L.; et al. Molecular profiling of isolated histological components of Wilms tumor implicates a common role for the Wnt signaling pathway in kidney and tumor development. ONCOLOGY, v. 75, n. 1-2, p. 81-91, 2008. (98/14335-2, 06/00054-0)

SILVA‚ A.P.M.; CHEN‚ J.; CARRARO‚ D.M.; CAMARGO‚ A.A.; OTHERS. Generation of longer 3′ cDNA fragments from massively parallel signature sequencing tags. Nucleic Acids Research, v. 32, n. 12, p. e94-e94, 2004. (98/14335-2)

CASTRO, NADIA P.; OSORIO, CYNTHIA A. B. T.; TORRES, CESAR; BASTOS, ELEN P.; MOURAO-NETO, MARIO; SOARES, FERNANDO A.; BRENTANI, HELENA P.; CARRARO, DIRCE M.. Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma. BREAST CANCER RESEARCH, v. 10, n. 5, p. R87, 2008. (98/14335-2)

LOPES‚ L.F.; PICCOLI‚ F.D.S.; PAIXÃO‚ V.A.; LATORRE‚ M.R.; CAMARGO‚ B.; SIMPSON‚ A.J.G.; CABALLERO‚ O.L.. Association of CYP3A4 genotype with detection of V$\gamma$/Jβ trans-rearrangements in the peripheral blood leukocytes of pediatric cancer patients undergoing chemotherapy for ALL. Leukemia Research, v. 28, n. 12, p. 1281-1286, 2004. (98/14335-2)

FROES MARQUES CAMPOS, ANTONIO HUGO JOSE; SILVA, ANDRE ABREU; DE CARVALHO MOTA, LOUISE DANIELLE; OLIVIERI, ELOISA RIBEIRO; PRESCINOTI, VERA CRISTINA; PATRAO, DIOGO; CAMARGO, LUIZ PAULO; BRENTANI, HELENA; CARRARO, DIRCE MARIA; BRENTANI, RICARDO RENZO; et al. The Value of a Tumor Bank in the Development of Cancer Research in Brazil: 13 Years of Experience at the A C Camargo Hospital. BIOPRESERVATION AND BIOBANKING, v. 10, n. 2, p. 168-173, APR 2012. (98/14335-2)

SILVA, A. P. M.; SOUZA, J. E.; GALANTE, P. A. F.; RIGGINS, G. J.; SOUZA, S. J. DE; CAMARGO, A. A.. The impact of SNPs on the interpretation of SAGE and MPSS experimental data. Nucleic Acids Research, v. 32, n. 20, p. 6104-6110, Nov. 2004. (98/14335-2)

STOLF, BEATRIZ S.; SANTOS, MARIANA M. S.; SIMAO, DANIEL F.; DIAZ, JUAN P.; CRISTO, ELIER B.; HIRATA JÚNIOR, ROBERTO; CURADO, MARIA P.; NEVES, EDUARDO J.; KOWALSKI, LUIZ P.; CARVALHO, ALEX F.. Class distinction between follicular adenomas and follicular carcinomas of the thyroid gland on the basis of their signature expression. Cancer, v. 106, n. 9, p. 1891-1900, May 2006. (99/07390-0, 98/14335-2, 99/11962-9)

GOMES, LUCIANA I.; ESTEVES, GUSTAVO H.; CARVALHO, ALEX F.; CRISTO, ELIER B.; HIRATA JÚNIOR, ROBERTO; MARTINS, WALESKA K.; MARQUES, SARAH M.; CAMARGO, LUIZ P.; BRENTANI, HELENA; PELOSOF, ADRIANE; et al. Expression profile of malignant and nonmalignant lesions of esophagus and stomach: differential activity of functional modules related to inflammation and lipid metabolism. Cancer Research, v. 65, n. 16, p. 7127-7136, Aug. 2005. (99/11962-9, 99/07390-0, 98/14335-2)

MEIRELES‚ S.I.; CRISTO‚ E.B.; CARVALHO‚ A.F.; HIRATA‚ R.; PELOSOF‚ A.; GOMES‚ L.I.; MARTINS‚ W.K.; BEGNAMI‚ M.D.; ZITRON‚ C.; MONTAGNINI‚ A.L.; et al. Molecular classifiers for gastric cancer and nonmalignant diseases of the gastric mucosa. Cancer Research, v. 64, n. 4, p. 1255, 2004. (98/14335-2, 99/07390-0, 99/11962-9)

RIBEIRO OLIVIERI, ELOISA HELENA; FRANCO, LUANA DE ANDRADE; PEREIRA, RAFAEL GOMES; CARVALHO MOTA, LOUISE DANIELLE; CAMPOS, ANTONIO HUGO J. F. M.; CARRARO, DIRCE MARIA. Biobanking Practice: RNA Storage at Low Concentration Affects Integrity. BIOPRESERVATION AND BIOBANKING, v. 12, n. 1, p. 46-52, FEB 1 2014. (98/14335-2, 08/57887-9)

CARRARO, DIRCE MARIA; AZEVEDO KOIKE FOLGUEIRA, MARIA APARECIDA; GARCIA LISBOA, BIANCA CRISTINA; RIBEIRO OLIVIERI, ELOISA HELENA; VITORINO KREPISCHI, ANA CRISTINA; DE CARVALHO, ALEX FIORINI; DE CARVALHO MOTA, LOUISE DANIELLE; PUGA, RENATO DAVID; MACIEL, MARIA DO SOCORRO; DEPIERI MICHELLI, RODRIGO AUGUSTO; et al. Comprehensive Analysis of BRCA1, BRCA2 and TP53 Germline Mutation and Tumor Characterization: A Portrait of Early-Onset Breast Cancer in Brazil. PLoS One, v. 8, n. 3, MAR 1 2013. (98/14335-2, 08/57887-9, 09/10088-7)