Abstract
This project has an innovator and emergent character in biomedical area because presents a new technology to obtain nanoparticle-incorporated diamond-like carbon (DLC) films in order to cover orthopedic alloys. For that, this project proposes create a new research line (Biomedical Nanotechnology) in an institution with recognized tradition in Biomedical Engineering research (IP&D/Univap). The DLC films will be produced using plasma enhanced chemical vapor deposition technique. The nanoparticles of biomedical interest will be crystalline diamond (NCD), titanium dioxide and gold. The incorporation of these nanoparticles in DLC bulk was developed by the proponent of this Project during her doctoring degree. NCD and TiO2 will be functionalizated, and gold nanoparticles will be synthesized to homogeneously disperse in hydrocarbon liquids that are precursor DLC formation. Commercial biomedical alloys will be the substrates. The structural and morphological analysis will be performed by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and Raman scattering spectroscopy. The films will be in vitro biologically characterizated using: (i) cell line like-L929 (ISSO 10993-5) and human osteoblast cells to evaluate cytotoxicity, cytocompatibility, bioactivity and biomineralization; (ii) bacterial strains to evaluate the bacteriostatic activity; and (iii) electrochemical assays to evaluate the anticorrosive effects using simulated body fluid, Ringer's solution and synovial solution. This project hopes prove the biocompatibility and anticorrosive effects in order to enable the use of DLC films in biomedical applications. (AU)
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