Role of adaptative immunity on the progress of ischemic heart disease after acute myocardial infarction

• Grant number: 12/51692-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: January 01, 2014
• End date: August 31, 2020
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Francisco Antonio Helfenstein Fonseca
• Grantee: Francisco Antonio Helfenstein Fonseca
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Pesquisadores principais: Maria Cristina de Oliveira Izar
• Associated scholarship(s): 18/07683-0 - Analytical methodology optimization by LC-MS/MS for determination of cardiovascular disease potential biomarkers in human plasma, BP.IC; 16/19045-2 - Determination of adenosine and differential protein after acute myocardial infartion, BP.IC

Abstract

The role of subtypes of lymphocytes in the progression of coronary heart disease may be a new strategic target in the therapy of myocardial infarction. The muscle loss following the coronary occlusion adds prognostic information and early reperfusion constitutes the key strategy for these patients. However, surrounding the necrotic core, an ischemic area is formed, that progresses to extension of the infarction or recovers, mainly during the first weeks after the ischemic insult. The determinants of cell viability are unknown, postulating that they arise from factors not only related to microcirculation or energy expenditure, but also to inflammatory and immune responses. Furthermore, the intense mobilization of progenitor cells secondary to myocardial infarction triggers large lymphocyte proliferation that colonizes plaques in development, contributing to recurrent ischemic outcomes. This project aims to better understanding of the immune and metabolic mechanisms involved. Specifically, we will study the adaptive immunity, with emphasis on lymphocytes subtypes involved in the early and late course of these subjects, including lipidomics and metabolomics, as well as the corresponding signaling pathways. Therapeutic pharmacological strategies and changes on intestine microflora will be evaluated up to 12 months. Finally, experimental study was designed to better understanding of the role of adaptive immunity on this scenario. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PINTO, LETICIA C. S.; MELLO, ANA P. Q.; IZAR, MARIA C. O.; DAMASCENO, NAGILA R. T.; NETO, ANTONIO M. F.; FRANCA, CAROLINA N.; CAIXETA, ADRIANO; BIANCO, HENRIQUE T.; POVOA, RUI M. S.; MOREIRA, FLAVIO T.; et al. Main differences between two highly effective lipid-lowering therapies in subclasses of lipoproteins in patients with acute myocardial infarction. LIPIDS IN HEALTH AND DISEASE, v. 20, n. 1, SEP 29 2021. (12/51692-7, 14/50983-3)

KLASSEN, ALINE; FACCIO, ANDREA TEDESCO; COSTA PICOSSI, CAROLINA RAISSA; MATOS CRUZ DEROGIS, PRISCILLA BENTO; DOS SANTOS FERREIRA, CARLOS EDUARDO; LOPES, ALINE SORIANO; SUSSULINI, ALESSANDRA; SANTA CRUZ, ELISA CASTANEDA; BASTOS, RAFAELA TUDELA; FONTOURA, STEFANIE CAROLINE; et al. Evaluation of two highly effective lipid-lowering therapies in subjects with acute myocardial infarction. SCIENTIFIC REPORTS, v. 11, n. 1, AUG 5 2021. (12/51692-7)

MARIA E. R. COSTE; CAROLINA N. FRANÇA; MARIA CRISTINA IZAR; DANIELA TEIXEIRA; MAYARI E. ISHIMURA; IEDA LONGO-MAUGERI; AMANDA S. BACCHIN; HENRIQUE TRIA BIANCO; FLAVIO T. MOREIRA; IBRAIM MASCIARELLI PINTO; et al. Alterações Precoces nas Interleucinas Circulantes e no Risco Inflamatório Residual após Infarto Agudo do Miocárdio. Arquivos Brasileiros de Cardiologia, v. 115, n. 6, p. 1104-1111, 2020-08-28. (12/51692-7)

FONSECA, FRANCISCO A. H.; IZAR, MARIA CRISTINA; MAUGERI, IEDA M. L.; BERWANGER, OTAVIO; DAMIANI, LUCAS P.; PINTO, IBRAIM M.; SZARF, GILBERTO; FRANCA, CAROLINA N.; BIANCO, HENRIQUE T.; MOREIRA, FLAVIO T.; et al. Effects of four antiplatelet/statin combined strategies on immune and inflammatory responses in patients with acute myocardial infarction undergoing pharmacoinvasive strategy: Design and rationale of the B and T Types of Lymphocytes Evaluation in Acute Myocardial Infarction (BATTLE-AMI) study: study protocol for a randomized controlled trial. Trials, v. 18, DEC 19 2017. (12/51692-7)

DE CARVALHO, DANIEL CARNEIRO; HELFENSTEIN FONSECA, FRANCISCO ANTONIO; DE OLIVEIRA IZAR, MARIA CRISTINA; PEREIRA ASSUNCAO SILVEIRA, ANA LUIZA; TULETA, IZABELA DOROTA; DO AMARAL, JONATAS BUSSADOR; NEVES, LUCAS MELO; LACERDA BACHI, ANDRE LUIS; FRANCA, CAROLINA NUNES. Monocytes presenting a pro-inflammatory profile persist in patients submitted to a long-term pharmacological treatment after acute myocardial infarction. FRONTIERS IN PHYSIOLOGY, v. 13, p. 11-pg., 2023-01-20. (12/51692-7, 17/01368-2)

LOTFOLLAHI, ZAHRA; MELLO, ANA P. Q.; FONSECA, FRANCISCO A. H.; MACHADO, LUCIENE O.; MATHIAS, ANDRESSA F.; IZAR, MARIA C.; DAMASCENO, NAGILA R. T.; OLIVEIRA, CRISTIANO L. P.; NETO, ANTONIO M. F.. Changes in lipoproteins associated with lipid-lowering and antiplatelet strategies in patients with acute myocardial infarction. PLoS One, v. 17, n. 8, p. 19-pg., 2022-08-30. (12/51692-7, 16/24531-3, 18/07340-5)

GISELE A. B. CANUTO; JOSÉ LUIZ DA COSTA; PEDRO L. R. DA CRUZ; ANA ROSA L. DE SOUZA; ANDRÉA T. FACCIO; ALINE KLASSEN; KARINA T. RODRIGUES; MARINA F. M. TAVARES. METABOLÔMICA: DEFINIÇÕES, ESTADO-DA-ARTE E APLICAÇÕES REPRESENTATIVAS. Química Nova, v. 41, n. 1, p. 75-91, 2018-01-00. (12/09822-0, 12/07361-6, 15/10650-8, 12/51692-7)

CIESLAROVA, ZUZANA; MAGALDI, MARIANA; BARROS, LUCELIA ALCANTARA; DO LAGO, CLAUDIMIR LUCIO; OLIVEIRA, DANIEL ROSSADO; HELFENSTEIN FONSECA, FRANCISCO ANTONIO; IZAR, MARIA CRISTINA; LOPES, ALINE SORIANO; MAGGI TAVARES, MARINA FRANCO; KLASSEN, ALINE. Capillary electrophoresis with dual diode array detection and tandem mass spectrometry to access cardiovascular biomarkers candidates in human urine: Trimethylamine-N-Oxide and L-carnitine. Journal of Chromatography A, v. 1583, p. 136-142, JAN 4 2019. (12/51692-7, 12/06642-1, 17/27059-6, 16/19045-2)

AMANDA S. BACCHIN; FRANCISCO A. H. FONSECA; RUI POVOA; GILBERTO SZARF; IBRAIM MASCIARELLI PINTO; ADRIANO MENDES CAIXETA; DANIELA TEIXEIRA; IEDA LONGO MAUGERI; MAYARI E. ISHIMURA; MARIA E. R. COSTE; et al. Estratégia Farmacoinvasiva em Idosos até 75 Anos ou Não Idosos: Análise de Parâmetros Bioquímicos e de Ressonância Nuclear Magnética Cardíaca. Arquivos Brasileiros de Cardiologia, v. 120, n. 1, 2023-01-09. (12/51692-7)

DA SILVA, LEANDRO SANTOS; GERMANO, DANIELLE BORGES; FONSECA, FRANCISCO ANTONIO HELFENSTEIN; SHIO, MARINA TIEMI; NALI, LUIZ HENRIQUE DA SILVA; TULETA, IZABELA DOROTA; JULIANO, YARA; IZAR, MARIA CRISTINA DE OLIVEIRA; RIBEIRO, ANA PAULA; KATO, JULIANA TIEKO; et al. Persistence of a proinflammatory status after treatment of the acute myocardial infarction. Geriatrics & Gerontology International, v. 23, n. 9, p. 8-pg., 2023-07-31. (12/51692-7, 17/01368-2)

CASAROTTI, ANA C. A.; TEIXEIRA, DANIELA; LONGO-MAUGERI, IEDA M.; ISHIMURA, MAYARI E.; COSTE, MARIA E. R.; BIANCO, HENRIQUE T.; MOREIRA, FLAVIO T.; BACCHIN, AMANDA F.; IZAR, MARIA C.; GONCALVES, JR., IRAN; et al. Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction. BIOSCIENCE REPORTS, v. 41, n. 2, FEB 3 2021. (12/51692-7)