Melatonin and the control of energy metabolism: basic, clinical and epidemiological research

• Grant number: 14/50457-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: July 01, 2015
• End date: June 30, 2020
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: José Cipolla Neto
• Grantee: José Cipolla Neto
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Principal investigators: Mario Fernando Prieto Peres
• Associated research grant(s): 19/10233-9 - XV Latin American Symposium on Chronobiology, AR.EXT; 19/10103-8 - Twenty-Fourth International Symposium on Shiftwork & Working Time, AR.EXT; 19/10213-8 - Twenty-Fourth International Symposium on Shiftwork & Working Time, AR.EXT; 19/08490-3 - 2nd Pan American Congress of Physiological Sciences, AR.EXT; 16/17127-1 - Melatonin and energy metabolism: epidemiological studies, AV.EXT
• Associated scholarship(s): 19/06294-2 - Phenotypic characterization of circadian rhythms and body mass index (BMI) in individuals with different genotypes for clock genes polymorphisms: comparison between college students from morning and evening schedules, BP.MS; 19/03624-1 - Association of sleep aspects with macronutrient consumption among night shift nursing professionals with excess weight, BP.IC; 19/05518-4 - The absence of melatonin during gestation and its influence on glycolysis and gluconeogenesis, BP.IC; + associated scholarships 18/09704-4 - Relationship between social jet lag and diabetes markers in overweight night workers, BP.IC; 17/15036-1 - Effect of Melatonin on the Phenotype and Function of Neutrophils in Wistar Rats with Walker-256 Tumor., BP.PD; 16/24956-4 - Effects of melatonin absence on lactation and maternal behavior, BP.IC; 14/22313-3 - Influence of the absence of maternal melatonin during pregnancy and lactation on neurogenesis and on somatic and sensorimotor development of the offspring., BP.DR; 15/26190-6 - Melatonin central role in food control and energy metabolism: interaction of melatonin and leptin, BP.PD; 11/51581-8 - Analysis of melatonina in women with infertility and submitted to program of in vitro fertilization: functional study in granulosa cells, BP.PD - associated scholarships

Abstract

Through a interdisciplinary multicentric research group, approaching the scientific object from three scientific levels (basic, clinical and epidemiological) and using the endocrinological and the chronobiological paradigms of analysis the aim of the pres (AU)

Scientific publications

(38)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA-ABREU, KLAUSEN; SILVA-DOS-SANTOS, NATHALIA MARIA; COELHO-DE-SOUZA, ANDRELINA NORONHA; FERREIRA-DA-SILVA, FRANCISCO WALBER; DA SILVA-ALVES, KERLY SHAMYRA; CARDOSO-TEIXEIRA, ANA CAROLINA; CIPOLLA-NETO, JOSE; LEAL-CARDOSO, JOSE HENRIQUE. Melatonin Reduces Excitability in Dorsal Root Ganglia Neurons with Inflection on the Repolarization Phase of the Action Potential. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 11, JUN 1 2019. (14/50457-0)

MARQUEZE, ELAINE C.; NOGUEIRA, LUCIANA F. R.; VETTER, CELINE; SKENE, DEBRA J.; CIPOLLA-NETO, JOSE; MORENO, CLAUDIA R. C.. Exogenous melatonin decreases circadian misalignment and body weight among early types. Journal of Pineal Research, JUN 2021. (14/50457-0)

DE SOUZA, CAROLINE A. P.; GALLO, CAMILA CONGENTINO; DE CAMARGO, LUDMILLA SCODELER; VERSIGNASSI DE CARVALHO, PAULA VARGAS; OLESCUCK, INGRID FERNANDES; MACEDO, FELIPE; DA CUNHA, FERNANDA MARQUES; CIPOLLA-NETO, JOSE; DO AMARAL, FERNANDA G.. Melatonin multiple effects on brown adipose tissue molecular machinery. Journal of Pineal Research, v. 66, n. 2, MAR 2019. (14/50457-0)

BALTATU, OVIDIU C.; AMARAL, FERNANDA G.; CAMPOS, LUCIANA A.; CIPOLLA-NETO, JOSE. Melatonin, mitochondria and hypertension. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 74, n. 21, p. 3955-3964, NOV 2017. (14/50457-0)

DE SANTANA, P. TEIXEIRA; MARQUEZE, E. CRISTINA. EFFECT OF FOODS RICH IN TRYPTOPHAN, MELATONIN AND COMPLEX VITAMINS A, B, C, D AND E ASSOCIATED WITH ADMINISTRATION OF MELATONIN ON SLEEP QUALITY OF WORKING WOMEN OVERWEIGHT NIGHT DAYS. Sleep Medicine, v. 115, p. 1-pg., 2024-02-01. (14/50457-0)

DO AMARAL, FERNANDA GASPAR; CIPOLLA-NETO, JOSE. A brief review about melatonin, a pineal hormone. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 62, n. 4, p. 8-pg., 2018-07-01. (14/50457-0)

BATTAGELLO, DANIELLA S.; LORENZON, ALINE R.; DINIZ, GIOVANNE B.; MOTTA-TEIXEIRA, LIVIA C.; KLEIN, MARIANNE O.; FERREIRA, JOZELIA G. P.; ARIAS, CARLOS M.; ADAMANTIDIS, ANTOINE; SITA, V, LUCIANE; CIPOLLA-NETO, JOSE; et al. The Rat Mammary Gland as a Novel Site of Expression of Melanin-Concentrating Hormone Receptor 1 mRNA and Its Protein Immunoreactivity. FRONTIERS IN ENDOCRINOLOGY, v. 11, JUL 31 2020. (15/05990-4, 16/02748-0, 17/16293-8, 10/52068-0, 16/04210-8, 17/17998-5, 14/50457-0, 12/04554-8, 14/13052-1, 16/18941-4, 16/19845-9, 16/02224-1)

TIUGANJI, NATALIA M.; NEHME, PATRICIA; MARQUEZE, ELAINE C.; ISHERWOOD, CHERYL M.; MARTINS, ANDRESSA J.; VASCONCELOS, SULEIMA; CIPOLLA-NETO, JOSE; LOWDEN, ARNE; SKENE, DEBRA J.; MORENO, CLAUDIA R. C.. Eating Behavior (Duration, Content, and Timing) Among Workers Living under Different Levels of Urbanization. NUTRIENTS, v. 12, n. 2, FEB 2020. (16/09582-0, 14/50457-0, 16/11155-3)

CIPOLLA-NETO, JOSE; AMARAL, FERNANDA GASPAR; SOARES-JR, JOSE MARIA; GALLO, CAMILA CONGENTINO; FURTADO, ANDRE; CAVACO, JOSE EDUARDO; GONCALVES, ISABEL; ALVES SANTOS, CECILIA REIS; QUINTELA, TELMA. he Crosstalk between Melatonin and Sex Steroid Hormone. Neuroendocrinology, v. 112, n. 2, MAR 2021. (14/50457-0)

BUONFIGLIO, DANIELLA; TCHIO, CYNTHIA; FURIGO, ISADORA; DONATO, JR., JOSE; BABA, KENKICHI; CIPOLLA-NETO, JOSE; TOSINI, GIANLUCA. Removing melatonin receptor type 1 signaling leads to selective leptin resistance in the arcuate nucleus. Journal of Pineal Research, v. 67, n. 2, SEP 2019. (15/26190-6, 14/50457-0, 17/02983-2)

SALGUEIRO BARBONI, MIRELLA TELLES; BUENO, CLARISSA; NAGY, BALAZS VINCE; MAIA, PATRICIA LOBO; MOREIRA VIDAL, KALLENE SUMMER; ALVES, ROSANA CARDOSO; REITER, RUSSEL J.; DO AMARAL, FERNANDA GASPAR; CIPOLLA-NETO, JOSE; VENTURA, DORA FIX. Melanopsin System Dysfunction in Smith-Magenis Syndrome Patients. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 59, n. 1, p. 362-369, JAN 2018. (14/26818-2, 14/50457-0, 14/06457-5, 15/22227-2, 16/04538-3, 16/22007-5)

VIEIRA, R. P. O.; NEHME, P. X. S. A.; MARQUEZE, E. C.; AMARAL, F. G.; CIPOLLA-NETO, J.; MORENO, C. R. C.. High social jetlag is correlated with nocturnal inhibition of melatonin production among night workers. CHRONOBIOLOGY INTERNATIONAL, v. 38, n. 8, p. 1170-1176, AUG 3 2021. (14/50457-0, 19/24327-5, 16/11155-3)

LOURENCO GOMES, PATRICIA RODRIGUES; MOTTA-TEIXEIRA, LIVIA CLEMENTE; GALLO, CAMILA CONGENTINO; BUONFIGLIO, DANIELLA DO CARMO; DE CAMARGO, LUDMILLA SCODELER; QUINTELA, TELMA; REITER, RUSSEL J.; DO AMARAL, FERNANDA GASPAR; CIPOLLA-NETO, JOSE. Maternal pineal melatonin in gestation and lactation physiology, and in fetal development and programming. General and Comparative Endocrinology, v. 300, JAN 1 2021. (14/50457-0)

TORRES-FARFAN, CLAUDIA; CIPOLLA NETO, JOSE; HERZOG, ERIK D.. Editorial: Decoding the Fetal Circadian System and Its Role in Adult Sickness and Health: Melatonin, a Dark History. FRONTIERS IN ENDOCRINOLOGY, v. 11, p. 2-pg., 2020-07-16. (14/50457-0)

SALGUEIRO BARBONI, MIRELLA TELLES; BUENO, CLARISSA; NAGY, BALAZS; MAIA, PATRICIA LOBO; MOREIRA VIDAL, KALLENE SUMMER; ALVES, ROSANA CARDOSO; AMARAL, FERNANDA GASPAR; CIPOLLA-NETO, JOSE; VENTURA, DORA FIX. Smith-Magenis Syndrome patients show reduced melanopsin response in the pupillary light reflex. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 58, n. 8, p. 4-pg., 2017-06-01. (14/26818-2, 14/50457-0, 15/22227-2, 14/06457-5, 16/04538-3)

GOBETTI, RENATA; BUENO, CLARISSA; SOSTER, LETICIA; AMARAL, FERNANDA; NETO, JOSE CIPOLLA. Sleep macroestructure of pinealectomized patients: Insights on physiological melatonin action in humans. Journal of Sleep Research, v. 33, p. 2-pg., 2024-09-01. (14/50457-0)

DO AMARAL, FERNANDA GASPAR; CIPOLLA-NETO, JOSE. A brief review about melatonin, a pineal hormone. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 62, n. 4, p. 472-479, JUL-AUG 2018. (14/50457-0)

BUONFIGLIO, DANIELLA; PARTHIMOS, RAFAELA; DANTAS, ROSANA; SILVA, RAYSA CERQUEIRA; GOMES, GUILHERME; ANDRADE-SILVA, JESSICA; RAMOS-LOBO, ANGELA; AMARAL, FERNANDA GASPAR; MATOS, RAPHAEL; SINESIO, JR., JOSE; et al. Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats. FRONTIERS IN ENDOCRINOLOGY, v. 9, MAR 27 2018. (15/26190-6, 16/24956-4, 17/01882-8, 14/50457-0)

DO AMARAL, FERNANDA GASPAR; ANDRADE-SILVA, JESSICA; KUWABARA, WILSON M. T.; CIPOLLA-NETO, JOSE. New insights into the function of melatonin and its role in metabolic disturbances. EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, v. 14, n. 4, p. 293-300, 2019. (14/50457-0)

PEDROSO, JOAO A. B.; CAMPOREZ, JOAO PAULO; BELPIEDE, LUCIANA T.; PINTO, RAFAELA S.; CIPOLLA-NETO, JOSE; DONATO, JOSE. Evaluation of Hepatic Steatosis in Rodents by Time-Domain Nuclear Magnetic Resonance. DIAGNOSTICS, v. 9, n. 4, DEC 2019. (14/50457-0, 18/04956-5, 17/02983-2)

MOTTA-TEIXEIRA, LIVIA CLEMENTE; MACHADO-NILS, ALINE VILAR; BATTAGELLO, DANIELLA SABINO; DINIZ, GIOVANNE BARONI; ANDRADE-SILVA, JESSICA; SILVA JR, SINESIO; MATOS, RAPHAEL AFONSO; DO AMARAL, FERNANDA GASPAR; XAVIER, GILBERTO FERNANDO; BITTENCOURT, JACKSON CIONI; et al. The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior. Hormones and Behavior, v. 105, p. 146-156, SEP 2018. (12/04554-8, 16/02224-1, 16/02748-0, 10/52068-0, 14/22313-3, 14/50457-0, 16/18941-4)

GONCALVES, ANDRE LEITE; FERREIRA, ADRIANA MARTINI; RIBEIRO, REINALDO TEIXEIRA; ZUKERMAN, ELIOVA; CIPOLLA-NETO, JOSE; PRIETO PERES, MARIO FERNANDO. Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 87, n. 10, p. 1127-1132, OCT 2016. (14/50457-0)

CIPOLLA-NETO, JOSE; DO AMARAL, FERNANDA GASPAR. Melatonin as a Hormone: New Physiological and Clinical Insights. ENDOCRINE REVIEWS, v. 39, n. 6, p. 990-1028, DEC 2018. (14/50457-0)

TATAGIBA KUWABARA, WILSON MITSUO; ANDRADE-SILVA, JESSICA; BERTAGLIA PEREIRA, JOICE NAIARA; SCIALFA, JULIETA HELENA; CIPOLLA-NETO, JOSE. Neutrophil activation causes tumor regression in Walker 256 tumor-bearing rats. SCIENTIFIC REPORTS, v. 9, NOV 11 2019. (17/15036-1, 14/50457-0)

NEHME, P. A.; AMARAL, F.; LOWDEN, A.; SKENE, D. J.; CIPOLLA-NETO, J.; MORENO, C. R. C.. Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring. Medical Hypotheses, v. 132, NOV 2019. (14/50457-0, 16/11155-3)

MARQUEZE, ELAINE C.; NOGUEIRA, LUCIANA F. R.; VETTER, CELINE; SKENE, DEBRA J.; CIPOLLA-NETO, JOSE; MORENO, CLAUDIA R. C.. Exogenous melatonin decreases circadian misalignment and body weight among early types. Journal of Pineal Research, v. 71, n. 2, SEP 2021. (14/50457-0)

MENDES, CAROLINE; GOMES, GUILHERME; BELPIEDE, LUCIANA TOCCI; BUONFIGLIO, DANIELLA DO CARMO; MOTTA-TEIXEIRA, LIVIA CLEMENTE; AMARAL, FERNANDA GASPAR; CIPOLLA-NETO, JOSE. The effects of melatonin daily supplementation to aged rats on the ability to withstand cold, thermoregulation and body weight. Life Sciences, v. 265, JAN 15 2021. (14/50457-0)

VEIGA, EDUARDO CARVALHO DE ARRUDA; SIMOES, RICARDO DOS SANTOS; CAVIOLA, LEONARDO L.; ABREU, LUIZ CARLOS; CAVALLI, RICARDO CARVALHO; CIPOLLA-NETO, JOSE; BARACAT, EDMUND CHADA; SOARES JUNIOR, JOSE MARIA. Melatonin and the cardiovascular system in animals: systematic review and meta-analysis. Clinics, v. 76, 2021. (14/50457-0)

HALPERN, BRUNO; MANCINI, MARCIO C.; MENDES, CAROLINE; MACHADO, CAMILA MARIA LONGO; PRANDO, SILVANA; SAPIENZA, MARCELO TATIT; BUCHPIGUEL, CARLOS ALBERTO; DO AMARAL, FERNANDA GASPAR; CIPOLLA-NETO, JOSE. Melatonin deficiency decreases brown adipose tissue acute thermogenic capacity of in rats measured by(18)F-FDG PET. DIABETOLOGY & METABOLIC SYNDROME, v. 12, n. 1, p. 7-pg., 2020-09-21. (14/50457-0)

AFSAR, BARIS; AFSAR, RENGIN ELSURER; SAG, ALAN A.; KANBAY, ASIYE; KORKMAZ, HAKAN; CIPOLLA-NETO, JOSE; COVIC, ADRIAN; ORTIZ, ALBERTO; KANBAY, MEHMET. Sweet dreams: therapeutic insights, targeting imaging and physiologic evidence linking sleep, melatonin and diabetic nephropathy. CLINICAL KIDNEY JOURNAL, v. 13, n. 4, p. 9-pg., 2020-08-01. (14/50457-0)

OLIVEIRA-ABREU, KLAUSEN; SILVA-DOS-SANTOS, NATHALIA MARIA; COELHO-DE-SOUZA, ANDRELINA NORONHA; FERREIRA-DA-SILVA, FRANCISCO WALBER; DA SILVA-ALVES, KERLY SHAMYRA; CARDOSO-TEIXEIRA, ANA CAROLINA; CIPOLLA-NETO, JOSE; LEAL-CARDOSO, JOSE HENRIQUE. Melatonin Reduces Excitability in Dorsal Root Ganglia Neurons with Inflection on the Repolarization Phase of the Action Potential. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 11, p. 13-pg., 2019-06-01. (14/50457-0)

GOMES, PATRICIA RODRIGUES LOURENCO; VILAS-BOAS, ELOISA APARECIDA; LEITE, EDUARDO DE ALMEIDA; MUNHOZ, ANA CLAUDIA; LUCENA, CAMILA FERRAZ; AMARAL, FERNANDA GASPAR DO; CARPINELLI, ANGELO RAFAEL; CIPOLLA-NETO, JOSE. Melatonin regulates maternal pancreatic remodeling and B-cell function during pregnancy and lactation. Journal of Pineal Research, v. 71, n. 1, FEB 2021. (14/50457-0)

RAMOS NOGUEIRA, LUCIANA FIDALGO; CRISPIM, CIBELE APARECIDA; CIPOLLA-NETO, JOSE; DE CASTRO MORENO, CLAUDIA ROBERTA; MARQUEZE, ELAINE CRISTINA. The Effect of Exogenous Melatonin on Eating Habits of Female Night Workers with Excessive Weight. NUTRIENTS, v. 14, n. 16, p. 12-pg., 2022-08-01. (14/50457-0)

BALTATU, OVIDIU CONSTANTIN; SENAR, SERGIO; CAMPOS, LUCIANA APARECIDA; CIPOLLA-NETO, JOSE. Cardioprotective Melatonin: Translating from Proof-of-Concept Studies to Therapeutic Use. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 18, SEP 2 2019. (14/50457-0)

COELHO, L. A.; ANDRADE-SILVA, J.; MOTTA-TEIXEIRA, L. C.; AMARAL, F. G.; REITER, R. J.; CIPOLLA-NETO, J.. The Absence of Pineal Melatonin Abolishes the Daily Rhythm of Tph1 (Tryptophan Hydroxylase 1), Asmt (Acetylserotonin O-Methyltransferase), and Aanat (Aralkylamine N-Acetyltransferase) mRNA Expressions in Rat Testes. Molecular Neurobiology, v. 56, n. 11, p. 7800-7809, NOV 2019. (14/50457-0, 14/17830-9)

FELIX GARRIDO, ANANDA LAIS; DUARTE, ADRIANA DE SOUSA; SANTANA, PATRICIA TEIXEIRA; RODRIGUES, GABRIELLA HABIB; PELLEGRINO, POLLYANNA; RAMOS NOGUEIRA, LUCIANA FIDALGO; CIPOLLA-NETO, JOSE; DE CASTRO MORENO, CLAUDIA ROBERTA; MARQUEZE, ELAINE CRISTINA. Eating habits, sleep, and a proxy for circadian disruption are correlated with dyslipidemia in overweight night workers. NUTRITION, v. 83, MAR 2021. (18/09704-4, 14/50457-0, 19/03624-1)

CAMPOS, LUCIANA APARECIDA; BUENO, CLARISSA; BARCELOS, ISABELLA P.; HALPERN, BRUNO; BRITO, LEANDRO C.; AMARAL, FERNANDA G.; BALTATU, OVIDIU CONSTANTIN; CIPOLLA-NETO, JOSE. Melatonin Therapy Improves Cardiac Autonomic Modulation in Pinealectomized Patients. FRONTIERS IN ENDOCRINOLOGY, v. 11, APR 30 2020. (14/50457-0)

GOBETTI, RENATA; SOSTER, LETICIA; BUENO, CLARISSA; AMARAL, FERNANDA; NETO, JOSE CIPOLLA. Immediate effects on sleep architecture of melatonin administration in pinealectomized patients. Journal of Sleep Research, v. 33, p. 1-pg., 2024-09-01. (14/50457-0)