Abstract
Chromosomes are major components of cells, packing the genetic material in a perfect organized structural and functional pattern. However, the chromosomes behavior during cell cycle is subjected to genomic rearrangements producing a wide variety of functional consequences with impact in cell disorders and also generating evolutionary novelties. Although several factors that mediate genomic rearrangements are now known, there are still many unanswered questions. In the light of high throughput era in generation of biological data, chromosome studies have also advanced to a higher level exploring high scale analyses of DNA, RNA, and proteins, and their interactive networks. Therefore, this grant application intend to explore chromosomal polymorphism (associated to B chromosomes and sex chromosomes) as models to investigate the structural and functional nature of chromosomal rearrangements during evolution. In this way, the objective of this project is to analyze chromosome rearrangements in the light of massive molecular data obtained from different biological models, in order to advance in the identification of origin and fate of chromosome changes and to comprehend their evolutionary and disease consequences. Additionally, the project also aims to perform the scientific divulgation of chromosome facts, in the light of an evolutionary and function perspective, in order to enforce a dialog between science and society. (AU)
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