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Methodological and statistics developments and evaluation in the collection and analysis of dietary data to obtain accurate measurements in epidemiological studies

Grant number: 16/20054-6
Support type:Regular Research Grants
Duration: February 01, 2018 - January 31, 2020
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Dirce Maria Lobo Marchioni
Grantee:Dirce Maria Lobo Marchioni
Home Institution: Hospital Universitário (HU). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Eliseu Verly Junior ; Isabela Judith Martins Bensenor ; José Eduardo Corrente ; Paulo Andrade Lotufo ; Sandra Patricia Crispim ; Valéria Troncoso Baltar
Associated scholarship(s):18/09818-0 - Proof of concept trial of the Brazilian version of GloboDiet software in the longitudinal study of adult health (ELSA-Brasil), BP.TT
18/07510-8 - Computational algorithms for identification of equivalences between nutritional composition and food intake databases: an adaptation to the Brazilian version of the GloboDiet software, BP.TT


In the complex research field of the role of lifestyle in the etiology of chronic diseases, diet is certainly one of the most difficult attributes to measure. Whereas all the physical and biological measurements, in any area of science, have measurement errors, it is imperative to continuously improve the technical aspects of measurement, including dietary intake assessment. Thus, this project aims to develop and evaluate methods of collection and analysis of dietary data to obtain accurate measurements of nutrient and food intake, aimed at use in epidemiological studies, especially for the Study of Adult Health Longitudinal (ELSA-Brasil), and specifically (1) estimate the measurement error associated with the use of GloboDiet platform through biomarker validation study; (2) test predictive equations of usual intake for use in analysis of epidemiological study, using data from the cohort ELSA-Brazil (3) estimate the underreporting, its determinants and its impact on the estimate of regular consumption; (4) estimate intrapersonal variability of dietary intake and intake of biomarkers; and (5) to estimate the calibration factors for the association of measures of correction using error models measures. It will assess the standardized methodology of performance to collect short-term dietary data (24 hour recall). This methodology, translated into GloboDiet platform was developed by the International Agency for Research on Cancer, which coordinated the realization of the Brazilian version. Using a sample of ELSA-Brazil study, we will use biomarkers of recovery and concentration, via metabolomics, to pursued our aims. Also, in the third wave of ELSA-Brazil cohort, it is intended that the estimate of dietary intak to be made by a food frequency questionnaire (FFQ) in association with this method. On completion of the project, this tool will be available for monitoring studies and research projects, providing comparability between different regions and population groups over time. Furthermore, it is foreseen to publish the results in high impact journals and training human resources in research. This project will contribute to the understanding and revealing the diet and health relationships. (AU)