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Interpopulational variation of secondary metabolites of arnicão (Lychnophora salicifolia Mart., Vernonieae, Asteraceae)

Grant number: 08/02323-3
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2008
Effective date (End): August 31, 2010
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Norberto Peporine Lopes
Grantee:Dayana Rubio Gouvea
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The Asteraceae family is characterized by its ability to produce a large variety of secondary metabolites, which are often responsible for the therapeutic or toxic effects of the plants. Lychnophora salicifolia Mart. (Vernonieae, Asteraceae) is the most polymorphic species and has the greatest geographical distribution of the genus Lychnophora, occurring in "Serra do Espinhaço" (Bahia), Minas Gerais and in the southeast of Goiás. Temporal and geographic variations in the total content, as well as the relative proportions of secondary metabolites in plants occur at different levels (seasonal and circadian; intraplant, interplants and interspecies), and despite the existence of a genetic control, the gene expression and the genotype itself may change due to the interaction of biochemical, physiological, ecological and evolutionary processes. Thus, it is clear the importance of determining the quali and quantitative chemical variations and the establishment of chemotypes which may occur in the species L. salicifolia using modern, fast and efficient methods of analysis, such as HPLC-MS, HPLC-DAD-MS. The verification of inter and intrapopulational variation in the production of these metabolites could be very useful for chemotaxonomics studies especially for the establishment of qualitative and quantitative chemical markers and for the establishment of chemotypes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOUVEA, DAYANA RUBIO; MELONI, FERNANDO; BELLO RIBEIRO, ARTHUR DE BARROS; CALLEGARI LOPES, JOAO LUIS; LOPES, NORBERTO PEPORINE. A new HPLC-DAD-MS/MS method for the simultaneous determination of major compounds in the crude extract of Lychnophora salicifolia Mart. (Brazilian arnicao) leaves: Application to chemical variability evaluation. Analytica Chimica Acta, v. 748, p. 28-36, OCT 20 2012. Web of Science Citations: 13.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GOUVEA, Dayana Rubio. Estudo da variação populacional dos metabólitos secundários do arnicão (Lychnophora salicifolia Mart., Vernonieae, Asteraceae). 2010. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto Ribeirão Preto.

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