Meat and heterocyclic amines intake, relationship with biomarkers for exposure and susceptibility to cancer in ISA-Capital study

• Grant number: 12/10965-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2012
• End date: January 31, 2016
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Principal Investigator: Dirce Maria Lobo Marchioni
• Grantee: Aline Martins de Carvalho
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 14/04607-0 - Relationship between meat and heterocyclic amines intake and biochemical and genetic biomarkers, BE.EP.DR

Abstract

High meat intake has been related with high risk to cancer. One of answer to meat has been related with cancer is the cooking methods that it is prepared, which it forms heterocyclic amines. These amines can form toxic substances during their metabolism, that is related with oxidative stress and DNA damage. However, people can present different answers to same dietetic exposition, they can present different risks or benefits with the same food intake. The study objective is evaluate the relationship between meat and heterocyclic amines intake with biomarkers for exposure to cancer (DNA adducts and malondialdehyde), considering the susceptibility biomarkers (enzymes polymorphisms) and social, demographics and life style factors in residents of city of Sao Pulo. Large cross-sectional health survey. Diet was assessed by 24-Hour dietary recalls and food propensity questionnaire. DNA will be extracted by salt method. Polymorphic variants will be identified by allele-specific PCR. The cancer risk will be analyzed by DNA adducts and malondialdehyde. Generalized Linear Models in STATA® will be used and P < 0.05 will be considered statistically significant. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARVALHO, A. M.; MIRANDA, A. M.; SANTOS, F. A.; LOUREIRO, A. P. M.; FISBERG, R. M.; MARCHIONI, D. M.. High intake of heterocyclic amines from meat is associated with oxidative stress. BRITISH JOURNAL OF NUTRITION, v. 113, n. 8, p. 1301-1307, APR 28 2015. (14/04607-0, 11/16225-6, 12/10965-0, 09/15831-0)

DE CARVALHO, ALINE MARTINS; FALCAO DE OLIVEIRA, ANTONIO ANAX; DE MELO LOUREIRO, ANA PAULA; FIGARO GATTAS, GILKA JORGE; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Arginine intake is associated with oxidative stress in a general population. NUTRITION, v. 33, p. 211-215, JAN 2017. (12/08617-4, 14/04607-0, 12/10965-0, 09/15831-0)

DE CARVALHO, ALINE MARTINS; FERREIRA CARIOCA, ANTONIO AUGUSTO; FISBERG, REGINA MARA; QI, LU; MARCHIONI, DIRCE MARIA. Joint association of fruit, vegetable, and heterocyclic amine intake with DNA damage levels in a general population. NUTRITION, v. 32, n. 2, p. 260-264, FEB 2016. (14/04607-0, 14/16347-2, 12/10965-0, 09/15831-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CARVALHO, Aline Martins de. Meat and heterocyclic amines intake as risk factors for cancer. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) São Paulo.