Standardized plant extracts for the treatment of chronic diseases: Mimosa spp.

• Grant number: 12/18760-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2013
• End date: April 30, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Wagner Vilegas
• Grantee: Marcelo José Dias Silva
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated research grant: 09/52237-9 - Standardized herbal medicines for the treatment of chronic diseases, AP.BTA.TEM

Abstract

This project proposes to develop methodologies for standardization of herbal extracts that may be applicable in the treatment of chronic diseases (ulcerative lesions, and inflammatory colitis). It is intended to develop analytical strategies that will allow qualitative and quantitative standardization of a plant extract, including identification of classes of substances, chemical markers and / or the active principles. As an object of study, will address the chemical-pharmacological a species native to northeastern Brazil and widely spread in the states of São Paulo and Minas Gerais: Mimosa caesalpiniifolia Benth. (Mimosoideae). This species is used for chronic respiratory problems, wound healing and inflammatory processes and showed promising results for anticancer activity, anti-inflammatory and antimicrobial. The studies involve 70% EtOH extracts of different organs (leaves, bark and roots), prepared according to pharmacopoeial standards. After pharmacological and toxicological evaluation, the leaf extracts are standardized according to standards. The work will be transdisciplinary, with participants from various campus UNESP (Laboratory of Biodiversity and Sustainability of Experimental Paulista Campus, Institute of Chemistry Araraquara, Faculty of Pharmaceutical Sciences of Araraquara, Biosciences Institute at Botucatu and others).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DIAS SILVA, MARCELO J.; SIMONET, ANA M.; SILVA, NAIARA C.; DIAS, AMANDA L. T.; VILEGAS, WAGNER; MACIAS, FRANCISCO A.. Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves. Journal of Natural Products, v. 82, n. 6, p. 1496-1502, JUN 2019. (15/21479-8, 12/18760-9, 09/52237-9)

SILVA, M. J. D.; CARVALHO, A. J. S.; ROCHA, C. Q.; VILEGAS, W.; SILVA, M. A.; GOUVEA, C. M. C. P.. Ethanolic extract of Mimosa caesalpiniifolia leaves: Chemical characterization and cytotoxic effect on human breast cancer MCF-7 cell line. SOUTH AFRICAN JOURNAL OF BOTANY, v. 93, p. 64-69, JUL 2014. (12/18760-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Marcelo José Dias. Hytochemical study and biological extracts of the leaves Mimosa caesalpiniifolia Bentham. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.