Standardization of plant extracts of Mimosa spp. development phytomedicines

• Grant number: 15/21479-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Effective date (Start): May 01, 2016
• Effective date (End): July 16, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Wagner Vilegas
• Grantee: Marcelo José Dias Silva
• Host Institution: Instituto de Biociências (IB-CLP). Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil
• Associated research grant: 09/52237-9 - Standardized herbal medicines for the treatment of chronic diseases, AP.BTA.TEM
• Associated scholarship(s): 17/01341-7 - Allelopathic potential of Mimosa spp. in the development of phytomedicines, BE.EP.PD

Abstract

The use of flora plants as a source of active ingredients have been shown to be increasingly effective in the search for medicines. However, little has been done to turn this potential in developing new products and patents. This proposal for a post-doctoral project under the theme "Standardized Herbal for treating chronic diseases" of FAPESP, aims to give continuity to the studies with the species Mimosa caesalpiniifolia towards developing a phytotherapeutic in accordance with the requirements of current legislation. Pharmacological tests shall be carried out with the compounds already isolated from Mimosa caesalpiniifolia, once in previous project these same compounds showed promising results for the development of plant health care, with antiiflamatória and antifungal activity. The work will be transdisciplinary, with participants from various campus of UNESP and other universities (Institute of Bioscience of São Vicente, Institute of chemistry of Araraquara and Institute of Bioscience of Botucatu), UEM (Department of Pharmacy - Palafito), UNIFESP (Institute of Bioscience of Baixada Santista) and UNIFAL/MG (Food and Drug Department). A partnership with the University of Cadiz (UCA) of Spain will allow the exchange of methodologies and scientific information with Spanish group of chemists and pharmacologists in the field of product development, enriching and supplementing the objectives initially proposed by project and by this project linked to it.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DIAS SILVA, MARCELO J.; SIMONET, ANA M.; SILVA, NAIARA C.; DIAS, AMANDA L. T.; VILEGAS, WAGNER; MACIAS, FRANCISCO A.. Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves. Journal of Natural Products, v. 82, n. 6, p. 1496-1502, JUN 2019. (15/21479-8, 12/18760-9, 09/52237-9)

DIAS SILVA, MARCELO JOSE; VILEGAS, WAGNER; DA SILVA, MARCELO APARECIDO; RIBEIRO PAIOTTI, ANA PAULA; PASTRELO, MAURICIO MERCALDI; MENIN RUIZ, PEDRO LUIZ; GOMES DE MOURA, CAROLINA FOOT; FUJIYAMA OSHIMA, CELINA TIZUKO; RIBEIRO, DANIEL ARAKI. The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression. DRUG RESEARCH, v. 68, n. 4, p. 196-204, APR 2018. (15/21479-8)