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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves

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Dias Silva, Marcelo J. [1] ; Simonet, Ana M. [2] ; Silva, Naiara C. [3] ; Dias, Amanda L. T. [3] ; Vilegas, Wagner [1] ; Macias, Francisco A. [2]
Total Authors: 6
[1] UNESP Univ Estadual Paulista, Biosci Inst, Coastal Campus Sao Vicente, BR-11330900 Sao Vicente, SP - Brazil
[2] Univ Cadiz, Fac Ciencias, Inst Biomol INBIO, Grp Alelopatia, Dept Quim Organ, C Republ Saharaui 7, Puerto Real 11510, Cadiz - Spain
[3] UNIFAL Univ Fed Alfenas, Fac Pharmaceut Sci, Rua Gabriel Monteir da Silva 714, BR-37130000 Alfenas, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Natural Products; v. 82, n. 6, p. 1496-1502, JUN 2019.
Web of Science Citations: 1

A bioassay-guided phytochemical study of a Mimosa caesalpiniifolia leaf extract with antifungal activity permitted the identification of 28 compounds, including the new 6-(beta-boivinopyranosyl)apigenin (1), 8-(beta-oliopyranosyl)-apigenin (2), (E)-6-(2-carboxyethenyl)apigenin (3), (E)-8-(2-carboxyethenyl)apigenin (4), and 7,5 `'-anhydro-6-(alpha-2,6-dideoxy-5-hydroxyarabinohexopyranosyl)apigenin (5). The structures of the new compounds were determined by comprehensive spectroscopic analysis, including 1D and 2D NMR techniques, and by mass spectrometry. Compound 3 showed promising activity and selectivity against Candida krusei (IC50 44 nM), which exhibits resistance to azoles. The association of the major components 3-beta-D-glucopyranosyloxysitosterol (8) and ethyl gallate (10) was synergistic against C. krusei, especially the IC values of compound 10, which were reduced by more than 100-fold. (AU)

FAPESP's process: 15/21479-8 - Standardization of plant extracts of Mimosa spp. development phytomedicines
Grantee:Marcelo José Dias Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/18760-9 - Standardized plant extracts for the treatment of chronic diseases: Mimosa spp.
Grantee:Marcelo José Dias Silva
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 09/52237-9 - Standardized herbal medicines for the treatment of chronic diseases
Grantee:Wagner Vilegas
Support type: BIOTA-FAPESP Program - Thematic Grants