Cytokines profile and its relation with parasitemia in cattle experimentally infected by Trypanosoma vivax

• Grant number: 14/10572-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2014
• End date: October 08, 2017
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Fabiano Antonio Cadioli
• Grantee: Otávio Luiz Fidelis Júnior
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Associated scholarship(s): 16/17401-6 - Cytokine profile determined by ELISA in cattle experimentally infected by Trypanosoma vivax, BE.EP.DR

Abstract

Bovine herd outbreaks by Trypanosoma vivax have occurred more frequently in Brazil, although Brazilian Ministry of Agriculture, Livestock and Supply (MAPA) does not consider this disease a problem and because of this, there is neither official control nor accurate records about its occurrence. In the future, due to its spread, T. vivax can bring greater livestock losses due to deaths and reducing production rates, observed when introduced into herds on non-endemic areas. However the diagnosis of this disease is a challenging task because many clinical, laboratory and immunological aspects are not fully elucidated. The aim of this study is to assess whether there is any variation of cytokines profile, IL-1b, IL-2, IL-4, IL-6, IL-10, IL-12, TNFa e IFNg associated with parasitemia of T. vivax in cattle experimentally infected with this hemoparasite; blood samples from three experimentally infected Girolando female (E1 to E3) with 2.0 x 107 trypomastigotes of "Lins" strain of T. vivax, obtained seven days before inoculation (D-7), on the day of inoculation (D0) , on the day following the inoculation (D1) and thereafter every seven days until 120 days after infection (DAI) will be used. The results obtained will help in understanding the pathophysiology of disease caused by T. vivax and may contribute to a refinement of the diagnosis of this disease. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FIDELIS JUNIOR, OTAVIO LUIZ; SAMPAIO, PAULO HENRIQUE; GONCALVES, LUIZ RICARDO; MACHADO, ROSANGELA ZACARIAS; ANDRE, MARCOS ROGERIO; WIJFFELS, GENE; CADIOLI, FABIANO ANTONIO. A Preliminary Study on the Relationship between Parasitaemia and Cytokine Expression of Peripheral Blood Cells in Trypanosoma vivax-Experimentally Infected Cattle. ANIMALS, v. 11, n. 11, NOV 2021. (16/17401-6, 12/02284-3, 14/10572-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FIDELIS JÚNIOR, Otávio Luiz. Cytokines profile and its relation with parasitemia in cattle experimentally infected by Trypanosoma vivax. 2017. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.