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Cytokines profile and its relation with parasitemia in cattle experimentally infected by Trypanosoma vivax

Grant number: 14/10572-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2014
Effective date (End): October 08, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Fabiano Antonio Cadioli
Grantee:Otávio Luiz Fidelis Júnior
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated scholarship(s):16/17401-6 - Cytokine profile determined by ELISA in cattle experimentally infected by Trypanosoma vivax, BE.EP.DR


Bovine herd outbreaks by Trypanosoma vivax have occurred more frequently in Brazil, although Brazilian Ministry of Agriculture, Livestock and Supply (MAPA) does not consider this disease a problem and because of this, there is neither official control nor accurate records about its occurrence. In the future, due to its spread, T. vivax can bring greater livestock losses due to deaths and reducing production rates, observed when introduced into herds on non-endemic areas. However the diagnosis of this disease is a challenging task because many clinical, laboratory and immunological aspects are not fully elucidated. The aim of this study is to assess whether there is any variation of cytokines profile, IL-1b, IL-2, IL-4, IL-6, IL-10, IL-12, TNFa e IFNg associated with parasitemia of T. vivax in cattle experimentally infected with this hemoparasite; blood samples from three experimentally infected Girolando female (E1 to E3) with 2.0 x 107 trypomastigotes of "Lins" strain of T. vivax, obtained seven days before inoculation (D-7), on the day of inoculation (D0) , on the day following the inoculation (D1) and thereafter every seven days until 120 days after infection (DAI) will be used. The results obtained will help in understanding the pathophysiology of disease caused by T. vivax and may contribute to a refinement of the diagnosis of this disease. (AU)

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
JÚNIOR, Otávio Luiz Fidelis. Perfil de citocinas e sua relação com a parasitemia em bovinos experimentalmente infectados por Trypanosoma vivax. 2017. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Agrárias e Veterinárias..

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