Analysis of the metabolism variation of chlorogenic acid and its derivatives

• Grant number: 15/09227-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2015
• End date: April 30, 2017
• Field of knowledge: Health Sciences - Pharmacy - Pharmacognosy
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Norberto Peporine Lopes
• Grantee: Eduarda Antunes Moreira
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

One of the problems in phytotherapic's use is the active substances dosage. Literature has reported seasonal, circadian and interpopulational variations for diverse secondary metabolites from different classes. Biological activity of a series of medicinal plants with anti inflammatory and analgesic effects has been related to the presence of chlorogenic acid and its derivatives. These substances, broadly discussed in oriental phytotherapy, are also important for bioprospecting programs and a series of other actions are described for them. Therefore, comprehension of seasonal and circadian variations that can occur during these substances' biosynthesis is directly connected to phytotherapics' quality parameters. Preliminary studies performed by our group suggest that plants which contain chlorogenic acid and its derivatives, when immediately frozen in liquid nitrogen, did not present significant concentration of the secondary metabolites. This data suggests a possible influence of catabolism of phenolic polymers instead of seasonal and circadian rhythm, however there is still a lack of experimental data that proves this information. Thus, the present study objectives to develop an analytical methodology to monitor seasonal and circadian variations of 8 species selected during a 12 months period. Aiming to contribute to this process comprehension, all of the experiments will be conducted with samples collected and submitted to traditional drying, comparing them to samples immediately frozen in liquid nitrogen. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOREIRA, DUARDA ANTUNES; PILON, ALAN CESAR; ANDRADE, LAURA ELENA; LOPES, NORBERTO PEPORINE. New Perspectives on Chlorogenic Acid Accumulation in Harvested Leaf Tissue: Impact on Traditional Medicine Preparations. ACS OMEGA, v. 3, n. 12, p. 18380-18386, DEC 2018. (14/50265-3, 15/09227-3, 10/17935-4, 16/13292-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MOREIRA, Eduarda Antunes. Analysis of the variation on chlorogenic acids\' concentration towards different post-harvest treatments. 2017. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.